Motif ID: Esrrb_Esrra

Z-value: 1.242

Transcription factors associated with Esrrb_Esrra:

Gene SymbolEntrez IDGene Name
Esrra ENSMUSG00000024955.7 Esrra
Esrrb ENSMUSG00000021255.11 Esrrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrramm10_v2_chr19_-_6921753_6921803-0.331.9e-01Click!
Esrrbmm10_v2_chr12_+_86421628_864216620.213.9e-01Click!


Activity profile for motif Esrrb_Esrra.

activity profile for motif Esrrb_Esrra


Sorted Z-values histogram for motif Esrrb_Esrra

Sorted Z-values for motif Esrrb_Esrra



Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrb_Esrra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_167393826 3.023 ENSMUST00000028005.2
 Mgst3
microsomal glutathione S-transferase 3
chr2_-_73911323 2.651 ENSMUST00000111996.1
ENSMUST00000018914.2
 Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chr1_+_181352618 2.582 ENSMUST00000161880.1
ENSMUST00000027795.7
 Cnih3

cornichon homolog 3 (Drosophila)

chr10_+_128083273 2.511 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr1_+_74791516 2.449 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr7_-_141429351 2.391 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
 Cend1


cell cycle exit and neuronal differentiation 1


chr8_+_84970068 2.343 ENSMUST00000164807.1
 Prdx2
peroxiredoxin 2
chr11_-_4704334 2.284 ENSMUST00000058407.5
 Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr19_-_47090610 2.280 ENSMUST00000096014.3
 Usmg5
upregulated during skeletal muscle growth 5
chr3_+_32736990 2.184 ENSMUST00000127477.1
ENSMUST00000121778.1
ENSMUST00000154257.1
 Ndufb5


NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5


chr17_+_43952999 2.122 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr7_-_141429433 2.103 ENSMUST00000124444.1
 Cend1
cell cycle exit and neuronal differentiation 1
chr11_-_33276334 2.088 ENSMUST00000183831.1
 Gm12117
predicted gene 12117
chr12_+_61523889 2.060 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr10_+_110920170 1.991 ENSMUST00000020403.5
 Csrp2
cysteine and glycine-rich protein 2
chr16_-_91931643 1.976 ENSMUST00000023677.3
 Atp5o
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chrX_-_141874870 1.910 ENSMUST00000182079.1
 Gm15294
predicted gene 15294
chr2_+_121357714 1.907 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr1_+_72824482 1.885 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr8_-_70523085 1.853 ENSMUST00000137610.1
ENSMUST00000121623.1
ENSMUST00000093456.5
ENSMUST00000118850.1
 Kxd1



KxDL motif containing 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 232 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.3 6.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.5 5.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.5 4.8 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.8 4.7 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
1.5 4.5 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.0 3.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 3.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 2.9 GO:0032091 negative regulation of protein binding(GO:0032091)
0.0 2.8 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.3 2.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 2.6 GO:0007614 short-term memory(GO:0007614)
0.1 2.6 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.6 2.5 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 2.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 2.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 2.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 2.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 2.2 GO:0048713 regulation of oligodendrocyte differentiation(GO:0048713)
0.4 1.9 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 13.1 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.2 12.0 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 10.2 GO:0043209 myelin sheath(GO:0043209)
0.0 7.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 7.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.7 7.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 4.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 4.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 3.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 2.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 2.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.5 GO:0000786 nucleosome(GO:0000786)
0.2 2.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 2.1 GO:0001726 ruffle(GO:0001726)
0.1 1.9 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 1.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.3 1.8 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 1.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.8 GO:0042788 polysomal ribosome(GO:0042788)
0.5 1.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 6.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6 6.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 5.4 GO:0003735 structural constituent of ribosome(GO:0003735)
1.2 4.8 GO:0004111 creatine kinase activity(GO:0004111)
0.6 4.8 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 4.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 4.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 4.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.7 3.7 GO:0043532 angiostatin binding(GO:0043532)
0.1 3.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 2.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 2.5 GO:0015266 protein channel activity(GO:0015266)
0.1 2.4 GO:0005109 frizzled binding(GO:0005109)
0.3 2.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.4 2.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3 2.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 2.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 2.0 GO:0008168 methyltransferase activity(GO:0008168)
0.0 1.9 GO:0070888 E-box binding(GO:0070888)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 1.9 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.9 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 1.8 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.5 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.2 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.2 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.2 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.1 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.1 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 1.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.0 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 0.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.8 PID_PLK1_PATHWAY PLK1 signaling events
0.4 0.7 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 23.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.4 7.7 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 7.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 3.6 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 3.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.0 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 2.5 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.1 2.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.1 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 2.0 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 1.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.8 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.8 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 1.7 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 1.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.5 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 1.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 1.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine