Motif ID: Nr4a3

Z-value: 0.570


Transcription factors associated with Nr4a3:

Gene SymbolEntrez IDGene Name
Nr4a3 ENSMUSG00000028341.3 Nr4a3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a3mm10_v2_chr4_+_48045144_480451600.321.9e-01Click!


Activity profile for motif Nr4a3.

activity profile for motif Nr4a3


Sorted Z-values histogram for motif Nr4a3

Sorted Z-values for motif Nr4a3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_66968559 1.345 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr19_-_4334001 1.249 ENSMUST00000176653.1
 Kdm2a
lysine (K)-specific demethylase 2A
chr15_+_25773985 1.093 ENSMUST00000125667.1
 Myo10
myosin X
chr16_+_10545390 1.046 ENSMUST00000115827.1
ENSMUST00000038145.6
ENSMUST00000150894.1
 Clec16a


C-type lectin domain family 16, member A


chrY_-_1245685 0.997 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr8_+_124793013 0.858 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr8_+_124793061 0.779 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr5_+_66968416 0.721 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr9_-_54661666 0.685 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr4_+_43578921 0.682 ENSMUST00000030190.8
 Rgp1
RGP1 retrograde golgi transport homolog (S. cerevisiae)
chrY_-_1245753 0.669 ENSMUST00000154004.1
 Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr11_-_115267236 0.626 ENSMUST00000106554.1
 Grin2c
glutamate receptor, ionotropic, NMDA2C (epsilon 3)
chr11_-_55033398 0.590 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6

chr15_+_100761741 0.582 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8
chrX_+_73675500 0.538 ENSMUST00000171398.1
 Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr7_+_102267795 0.519 ENSMUST00000033289.4
 Stim1
stromal interaction molecule 1
chr17_-_35909626 0.475 ENSMUST00000141132.1
 Atat1
alpha tubulin acetyltransferase 1
chr7_-_98162318 0.472 ENSMUST00000107112.1
 Capn5
calpain 5
chr5_+_16553488 0.465 ENSMUST00000030683.3
 Hgf
hepatocyte growth factor
chr19_+_46152505 0.439 ENSMUST00000026254.7
 Gbf1
golgi-specific brefeldin A-resistance factor 1
chr11_+_113619318 0.432 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr11_+_116657106 0.428 ENSMUST00000116318.2
 Gm11744
predicted gene 11744
chr6_-_112946754 0.423 ENSMUST00000113169.2
 Srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr19_-_45998479 0.413 ENSMUST00000045396.7
 9130011E15Rik
RIKEN cDNA 9130011E15 gene
chr2_-_33468493 0.411 ENSMUST00000113156.1
ENSMUST00000028125.5
ENSMUST00000126442.1
 Zbtb43


zinc finger and BTB domain containing 43


chr2_-_167492826 0.395 ENSMUST00000109211.2
ENSMUST00000057627.9
 Spata2

spermatogenesis associated 2

chr16_+_10545339 0.392 ENSMUST00000066345.7
ENSMUST00000115824.3
ENSMUST00000155633.1
 Clec16a


C-type lectin domain family 16, member A


chr16_-_4523056 0.384 ENSMUST00000090500.3
ENSMUST00000023161.7
 Srl

sarcalumenin

chr9_+_75071386 0.376 ENSMUST00000155282.2
 Myo5a
myosin VA
chr4_-_126202583 0.370 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
 Thrap3


thyroid hormone receptor associated protein 3


chr19_-_37207293 0.364 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
 Cpeb3




cytoplasmic polyadenylation element binding protein 3




chr7_+_30712209 0.358 ENSMUST00000005692.6
ENSMUST00000170371.1
 Atp4a

ATPase, H+/K+ exchanging, gastric, alpha polypeptide

chr9_-_64341145 0.353 ENSMUST00000120760.1
ENSMUST00000168844.2
 Dis3l

DIS3 mitotic control homolog (S. cerevisiae)-like

chr4_+_137993016 0.339 ENSMUST00000105830.2
ENSMUST00000084215.5
ENSMUST00000058133.3
ENSMUST00000139759.1
 Eif4g3



eukaryotic translation initiation factor 4 gamma, 3



chr6_-_28421680 0.325 ENSMUST00000090511.3
 Gcc1
golgi coiled coil 1
chr12_-_93929102 0.324 ENSMUST00000180321.1
 Gm9726
predicted gene 9726
chr7_-_79466167 0.312 ENSMUST00000073889.7
 Polg
polymerase (DNA directed), gamma
chr11_+_70764209 0.310 ENSMUST00000060444.5
 Zfp3
zinc finger protein 3
chr6_+_113531675 0.308 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr11_+_115475645 0.304 ENSMUST00000035240.6
 Armc7
armadillo repeat containing 7
chr19_+_44989073 0.278 ENSMUST00000026225.8
 Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chrX_+_101299143 0.270 ENSMUST00000118111.1
ENSMUST00000130555.1
ENSMUST00000151528.1
 Nlgn3


neuroligin 3


chr11_+_74649462 0.250 ENSMUST00000092915.5
ENSMUST00000117818.1
 Cluh

clustered mitochondria (cluA/CLU1) homolog

chr15_-_76918010 0.247 ENSMUST00000048854.7
 Zfp647
zinc finger protein 647
chr12_+_4082574 0.246 ENSMUST00000020986.7
 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr4_+_134396320 0.242 ENSMUST00000105869.2
 Pafah2
platelet-activating factor acetylhydrolase 2
chr6_-_113531575 0.239 ENSMUST00000032425.5
 Emc3
ER membrane protein complex subunit 3
chr12_-_84194007 0.238 ENSMUST00000110294.1
 Elmsan1
ELM2 and Myb/SANT-like domain containing 1
chr16_+_84834901 0.225 ENSMUST00000114184.1
 Gabpa
GA repeat binding protein, alpha
chr2_-_163417092 0.217 ENSMUST00000127038.1
 Oser1
oxidative stress responsive serine rich 1
chr17_+_17831004 0.204 ENSMUST00000172097.2
 4930546H06Rik
RIKEN cDNA 4930546H06 gene
chr7_+_45897429 0.203 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr3_-_89773221 0.165 ENSMUST00000038450.1
 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr8_+_119862239 0.160 ENSMUST00000034287.8
 Klhl36
kelch-like 36
chr7_-_28598140 0.160 ENSMUST00000108283.1
ENSMUST00000040531.8
 Pak4
Samd4b
p21 protein (Cdc42/Rac)-activated kinase 4
sterile alpha motif domain containing 4B
chrX_+_101299207 0.160 ENSMUST00000065858.2
 Nlgn3
neuroligin 3
chr6_-_76497631 0.152 ENSMUST00000097218.5
 Gm9008
predicted pseudogene 9008
chr15_-_79141197 0.130 ENSMUST00000169604.1
 1700088E04Rik
RIKEN cDNA 1700088E04 gene
chr17_-_35910032 0.125 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
 Atat1




alpha tubulin acetyltransferase 1




chr7_+_130865835 0.123 ENSMUST00000075181.4
ENSMUST00000048180.5
 Plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

chr4_+_116075269 0.119 ENSMUST00000030471.8
 Lrrc41
leucine rich repeat containing 41
chrX_-_71492799 0.111 ENSMUST00000037391.5
ENSMUST00000114586.2
ENSMUST00000114587.2
 Cd99l2


CD99 antigen-like 2


chr15_-_79804717 0.110 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr2_+_158794807 0.109 ENSMUST00000029186.7
ENSMUST00000109478.2
ENSMUST00000156893.1
 Dhx35


DEAH (Asp-Glu-Ala-His) box polypeptide 35


chr1_+_75435930 0.102 ENSMUST00000037796.7
ENSMUST00000113584.1
ENSMUST00000145166.1
ENSMUST00000143730.1
ENSMUST00000133418.1
ENSMUST00000144874.1
ENSMUST00000140287.1
 Gmppa






GDP-mannose pyrophosphorylase A






chr11_-_61494173 0.096 ENSMUST00000101085.2
ENSMUST00000079080.6
ENSMUST00000108714.1
 Mapk7


mitogen-activated protein kinase 7


chr2_-_180273488 0.095 ENSMUST00000108891.1
 Cables2
CDK5 and Abl enzyme substrate 2
chr4_-_43578824 0.091 ENSMUST00000030189.7
 Gba2
glucosidase beta 2
chr4_+_131873608 0.085 ENSMUST00000053819.3
 Srsf4
serine/arginine-rich splicing factor 4
chr7_+_125603420 0.084 ENSMUST00000033000.6
 Il21r
interleukin 21 receptor
chr9_-_22085391 0.084 ENSMUST00000179422.1
ENSMUST00000098937.3
ENSMUST00000177967.1
ENSMUST00000180180.1
 Ecsit



ECSIT homolog (Drosophila)



chr7_+_45896941 0.083 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr4_+_134397380 0.075 ENSMUST00000105870.1
 Pafah2
platelet-activating factor acetylhydrolase 2
chr2_-_165283599 0.048 ENSMUST00000155289.1
 Slc35c2
solute carrier family 35, member C2
chr15_-_102516806 0.046 ENSMUST00000169162.1
ENSMUST00000023812.2
ENSMUST00000165174.1
ENSMUST00000169367.1
ENSMUST00000169377.1
 Map3k12




mitogen-activated protein kinase kinase kinase 12




chr13_-_41847482 0.043 ENSMUST00000072012.3
 Adtrp
androgen dependent TFPI regulating protein
chr6_+_91156772 0.040 ENSMUST00000143621.1
 Hdac11
histone deacetylase 11
chr16_-_20730544 0.036 ENSMUST00000076422.5
 Thpo
thrombopoietin
chr8_-_120668121 0.034 ENSMUST00000034277.7
 Emc8
ER membrane protein complex subunit 8
chr9_+_22003035 0.025 ENSMUST00000115331.2
ENSMUST00000003493.7
 Prkcsh

protein kinase C substrate 80K-H

chr1_+_137966529 0.020 ENSMUST00000182158.1
 A430106G13Rik
RIKEN cDNA A430106G13 gene
chr6_-_137571007 0.011 ENSMUST00000100841.2
 Eps8
epidermal growth factor receptor pathway substrate 8
chr8_-_123894736 0.011 ENSMUST00000034453.4
 Acta1
actin, alpha 1, skeletal muscle

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.2 0.6 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.2 1.5 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 1.2 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.1 0.4 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.4 GO:2000331 regulation of terminal button organization(GO:2000331)
0.1 0.4 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.5 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.1 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 0.5 GO:1902947 regulation of tau-protein kinase activity(GO:1902947)
0.1 0.3 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.1 1.6 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 0.3 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.0 0.3 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 0.4 GO:0030432 peristalsis(GO:0030432)
0.0 0.4 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.4 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.1 GO:0070375 ERK5 cascade(GO:0070375)
0.0 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.6 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 0.2 GO:1903351 response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351)
0.0 0.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.5 GO:0072337 modified amino acid transport(GO:0072337)
0.0 0.6 GO:0001964 startle response(GO:0001964)
0.0 0.3 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.1 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.0 0.7 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.4 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 1.1 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.4 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.0 GO:0015786 UDP-glucose transport(GO:0015786)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042642 actomyosin, myosin complex part(GO:0042642)
0.1 0.6 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.5 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.3 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 1.1 GO:0016459 myosin complex(GO:0016459)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.6 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 1.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 0.4 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.5 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.6 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.4 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 0.3 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 0.1 GO:0001847 opsonin receptor activity(GO:0001847)
0.0 0.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.5 GO:0042056 chemoattractant activity(GO:0042056)
0.0 1.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.3 GO:0000146 microfilament motor activity(GO:0000146) ATP-dependent protein binding(GO:0043008)
0.0 0.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.4 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.4 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.4 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.3 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.3 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.1 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing