Motif ID: Ebf1

Z-value: 1.424


Transcription factors associated with Ebf1:

Gene SymbolEntrez IDGene Name
Ebf1 ENSMUSG00000078561.3 Ebf1
Ebf1 ENSMUSG00000057098.8 Ebf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ebf1mm10_v2_chr11_+_44617310_446173360.322.0e-01Click!


Activity profile for motif Ebf1.

activity profile for motif Ebf1


Sorted Z-values histogram for motif Ebf1

Sorted Z-values for motif Ebf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ebf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_37433138 5.272 ENSMUST00000115038.1
 Robo3
roundabout homolog 3 (Drosophila)
chr7_-_30973464 4.314 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr7_-_30973367 3.768 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr13_-_53286052 3.192 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr7_-_142899985 3.175 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr14_-_34374617 3.145 ENSMUST00000023826.4
 Sncg
synuclein, gamma
chr2_-_26246707 3.141 ENSMUST00000166349.1
 C030048H21Rik
RIKEN cDNA C030048H21 gene
chr7_-_30973399 3.128 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr2_+_84840612 3.121 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr19_-_45742873 2.854 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr5_+_136967859 2.842 ENSMUST00000001790.5
 Cldn15
claudin 15
chr2_+_172550991 2.755 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr6_-_23248264 2.560 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr16_+_92498122 2.476 ENSMUST00000023670.3
 Clic6
chloride intracellular channel 6
chr13_+_113035111 2.408 ENSMUST00000180543.1
ENSMUST00000181568.1
ENSMUST00000109244.2
ENSMUST00000181117.1
ENSMUST00000181741.1
 Cdc20b




cell division cycle 20B




chr2_+_131186942 2.362 ENSMUST00000028804.8
ENSMUST00000079857.8
 Cdc25b

cell division cycle 25B

chr10_+_108332173 2.313 ENSMUST00000095313.3
 Pawr
PRKC, apoptosis, WT1, regulator
chr17_-_34000257 2.287 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
 H2-K1




histocompatibility 2, K1, K region




chr7_-_110061319 2.280 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr17_+_29093763 2.247 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 728 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 11.2 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.8 6.1 GO:2001198 regulation of dendritic cell differentiation(GO:2001198)
0.4 5.8 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
1.1 5.3 GO:0061642 chemoattraction of axon(GO:0061642)
0.3 5.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
1.6 4.7 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.5 4.4 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production(GO:0032725)
0.1 4.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 4.1 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.9 3.7 GO:0046061 dATP catabolic process(GO:0046061)
0.6 3.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.1 3.2 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.8 3.2 GO:0042414 epinephrine metabolic process(GO:0042414)
1.0 3.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.6 3.0 GO:0015671 oxygen transport(GO:0015671)
0.2 3.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.6 2.9 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.6 2.8 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.6 2.8 GO:2000157 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.4 2.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 287 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 11.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 9.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 8.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 4.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 4.2 GO:0005581 collagen trimer(GO:0005581)
0.0 4.0 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 4.0 GO:0000790 nuclear chromatin(GO:0000790)
1.3 3.9 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2 3.9 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 3.9 GO:0009897 external side of plasma membrane(GO:0009897)
1.3 3.8 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 3.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 3.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.2 3.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.3 3.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 3.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 3.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 3.3 GO:0043256 laminin complex(GO:0043256)
0.2 3.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 3.2 GO:0035686 sperm fibrous sheath(GO:0035686)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 412 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 13.9 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 9.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 8.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 6.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 5.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 5.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.2 5.1 GO:0070410 co-SMAD binding(GO:0070410)
0.4 4.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.5 4.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
1.4 4.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.6 4.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.0 3.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 3.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.3 3.6 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 3.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.3 3.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.5 3.4 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.2 3.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6 3.0 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 3.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 7.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 6.5 PID_FGF_PATHWAY FGF signaling pathway
0.6 5.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 5.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.8 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 4.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 4.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 4.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 4.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 3.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 2.4 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.3 PID_BARD1_PATHWAY BARD1 signaling events
0.3 2.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 1.8 PID_ALK2_PATHWAY ALK2 signaling events
0.1 1.8 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
1.7 1.7 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.4 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 9.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 7.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 7.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 6.8 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.1 5.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.2 5.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 4.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 4.5 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 4.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.5 4.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 4.0 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.4 3.9 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.2 3.9 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 3.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 3.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 3.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.9 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 2.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis