Motif ID: Nhlh1

Z-value: 0.979


Transcription factors associated with Nhlh1:

Gene SymbolEntrez IDGene Name
Nhlh1 ENSMUSG00000051251.3 Nhlh1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nhlh1mm10_v2_chr1_-_172057573_172057598-0.644.5e-03Click!


Activity profile for motif Nhlh1.

activity profile for motif Nhlh1


Sorted Z-values histogram for motif Nhlh1

Sorted Z-values for motif Nhlh1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nhlh1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 3.477 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr4_-_64046925 2.915 ENSMUST00000107377.3
 Tnc
tenascin C
chr10_-_27616895 2.564 ENSMUST00000092639.5
 Lama2
laminin, alpha 2
chr4_+_104367549 1.846 ENSMUST00000106830.2
 Dab1
disabled 1
chr5_+_117841839 1.743 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr2_+_70562007 1.557 ENSMUST00000094934.4
 Gad1
glutamate decarboxylase 1
chr14_+_119138415 1.486 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr15_-_71727815 1.438 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr6_-_148444336 1.400 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr12_+_82616885 1.337 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr2_-_162661075 1.335 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chrX_-_162643575 1.277 ENSMUST00000101102.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr5_+_147188678 1.223 ENSMUST00000065382.5
 Gsx1
GS homeobox 1
chrX_-_162643629 1.114 ENSMUST00000112334.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr6_-_101377897 1.114 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr5_-_139130159 1.088 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr10_-_121311034 1.050 ENSMUST00000064107.5
 Tbc1d30
TBC1 domain family, member 30
chr11_+_50602072 1.025 ENSMUST00000040523.8
 Adamts2
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
chr1_-_22805994 1.005 ENSMUST00000097808.4
 Rims1
regulating synaptic membrane exocytosis 1
chr1_-_134955847 0.998 ENSMUST00000168381.1
 Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 359 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.5 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.5 3.3 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.4 2.0 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0 1.9 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 1.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 1.8 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.6 1.7 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.3 1.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 1.7 GO:0048709 oligodendrocyte differentiation(GO:0048709)
0.5 1.6 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.3 1.6 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 1.5 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.4 1.4 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.2 1.2 GO:0055091 phospholipid homeostasis(GO:0055091)
0.1 1.2 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.1 1.1 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 1.1 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 1.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 1.1 GO:0003333 amino acid transmembrane transport(GO:0003333)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0060077 inhibitory synapse(GO:0060077)
0.1 3.4 GO:0030673 axolemma(GO:0030673)
0.0 3.2 GO:0031594 neuromuscular junction(GO:0031594)
0.1 3.1 GO:0005605 basal lamina(GO:0005605)
0.0 3.0 GO:0005802 trans-Golgi network(GO:0005802)
0.2 2.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.7 GO:0031672 A band(GO:0031672)
0.0 2.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 1.7 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 1.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.5 GO:0043679 axon terminus(GO:0043679)
0.3 1.3 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.1 1.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.3 GO:0014704 intercalated disc(GO:0014704)
0.3 1.2 GO:0044307 dendritic branch(GO:0044307)
0.1 1.2 GO:0005682 U5 snRNP(GO:0005682)
0.0 1.2 GO:0033268 node of Ranvier(GO:0033268)
0.0 1.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.4 1.1 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 227 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0005096 GTPase activator activity(GO:0005096)
0.5 3.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 3.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.4 2.6 GO:0045545 syndecan binding(GO:0045545)
0.0 1.9 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.8 GO:0042169 SH2 domain binding(GO:0042169)
0.6 1.7 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 1.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.6 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.3 1.4 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 1.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 1.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 1.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 2.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 2.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.7 PID_SHP2_PATHWAY SHP2 signaling
0.0 1.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.5 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 0.5 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.5 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.5 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.5 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.1 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 2.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.8 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.8 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 1.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.6 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 1.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.3 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.2 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 1.0 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 0.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.9 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels