Motif ID: Hsf4
Z-value: 0.956
Transcription factors associated with Hsf4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hsf4 | ENSMUSG00000033249.4 | Hsf4 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 130 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 5.2 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 0.6 | 3.0 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.3 | 1.8 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.2 | 1.7 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.5 | 1.5 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 0.1 | 1.5 | GO:0034453 | microtubule anchoring(GO:0034453) |
| 0.0 | 1.5 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 1.5 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.0 | 1.3 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.3 | 1.2 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.1 | 1.2 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.1 | 1.1 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.0 | 1.1 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 1.1 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.1 | 1.0 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.0 | 1.0 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.2 | 0.9 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 0.2 | 0.9 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.1 | 0.9 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 0.9 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 55 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 5.2 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
| 0.1 | 1.7 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 1.4 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.1 | 1.3 | GO:0046930 | pore complex(GO:0046930) |
| 0.1 | 1.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 1.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 1.0 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 1.0 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 0.8 | GO:0031415 | NatA complex(GO:0031415) |
| 0.1 | 0.8 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 0.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 0.6 | GO:0000938 | GARP complex(GO:0000938) |
| 0.1 | 0.6 | GO:0033503 | HULC complex(GO:0033503) |
| 0.0 | 0.6 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 0.6 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.6 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 0.5 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.0 | 0.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 84 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.2 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.0 | 2.1 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 1.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.3 | 1.8 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 1.7 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.0 | 1.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 1.6 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 1.6 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.2 | 1.5 | GO:0043199 | sulfate binding(GO:0043199) |
| 0.2 | 1.3 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.0 | 1.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 1.2 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.3 | 1.0 | GO:0004155 | 6,7-dihydropteridine reductase activity(GO:0004155) |
| 0.1 | 1.0 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.2 | 0.9 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.1 | 0.9 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.1 | 0.8 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.8 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 0.8 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.2 | 0.7 | GO:0047256 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 26 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.2 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.8 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 1.8 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.6 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.1 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.1 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.9 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.9 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 0.9 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.8 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.7 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.6 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.5 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.4 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.4 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.3 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.3 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.3 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.3 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 26 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.2 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 3.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 2.8 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 2.7 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 1.5 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 1.3 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 1.3 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.1 | REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 0.9 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.7 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 0.6 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 0.6 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.6 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 0.5 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.4 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.0 | 0.4 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.3 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.3 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
