Motif ID: Spi1

Z-value: 0.940


Transcription factors associated with Spi1:

Gene SymbolEntrez IDGene Name
Spi1 ENSMUSG00000002111.8 Spi1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spi1mm10_v2_chr2_+_91082362_910823900.503.4e-02Click!


Activity profile for motif Spi1.

activity profile for motif Spi1


Sorted Z-values histogram for motif Spi1

Sorted Z-values for motif Spi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Spi1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_95904683 1.875 ENSMUST00000147962.1
ENSMUST00000036181.8
 Car14

carbonic anhydrase 14

chr6_-_23248264 1.530 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_127218303 1.377 ENSMUST00000106313.1
 Sept1
septin 1
chr7_-_127218390 1.317 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr11_+_98412461 1.088 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr15_+_39006272 1.051 ENSMUST00000179165.1
ENSMUST00000022906.7
 Fzd6

frizzled homolog 6 (Drosophila)

chr2_+_84840612 1.030 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr2_-_57113053 1.013 ENSMUST00000112627.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr7_-_102250086 0.942 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr3_+_131110350 0.920 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr7_+_127876796 0.920 ENSMUST00000131000.1
 Zfp646
zinc finger protein 646
chr13_+_48261427 0.896 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr6_-_72789240 0.882 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr9_+_35423582 0.878 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr16_+_32608973 0.860 ENSMUST00000120680.1
 Tfrc
transferrin receptor
chr7_+_75701965 0.842 ENSMUST00000094307.3
 Akap13
A kinase (PRKA) anchor protein 13
chr7_+_75610038 0.817 ENSMUST00000125771.1
 Akap13
A kinase (PRKA) anchor protein 13
chr2_+_105675478 0.809 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6

chr4_+_126556994 0.806 ENSMUST00000147675.1
 Clspn
claspin
chr17_+_29090969 0.800 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 611 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.7 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.4 2.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.2 1.8 GO:0015670 carbon dioxide transport(GO:0015670)
0.2 1.8 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.4 1.7 GO:0045608 inhibition of neuroepithelial cell differentiation(GO:0002085) negative regulation of auditory receptor cell differentiation(GO:0045608)
0.3 1.7 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 1.7 GO:0051639 actin filament network formation(GO:0051639)
0.5 1.6 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 1.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 1.6 GO:0045830 positive regulation of isotype switching(GO:0045830)
0.5 1.5 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.2 1.5 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.2 1.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 1.4 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 1.3 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 1.3 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 1.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 1.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.3 1.2 GO:1903416 response to glycoside(GO:1903416)
0.1 1.2 GO:0038092 nodal signaling pathway(GO:0038092)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 233 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0005667 transcription factor complex(GO:0005667)
0.3 2.6 GO:0072687 meiotic spindle(GO:0072687)
0.0 2.5 GO:0016459 myosin complex(GO:0016459)
0.0 1.9 GO:0000785 chromatin(GO:0000785)
0.0 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 1.4 GO:0008623 CHRAC(GO:0008623)
0.1 1.4 GO:0043219 lateral loop(GO:0043219)
0.1 1.4 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 1.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 1.3 GO:0005871 kinesin complex(GO:0005871)
0.3 1.2 GO:0032127 dense core granule membrane(GO:0032127)
0.1 1.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.2 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 1.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.2 GO:0031985 Golgi cisterna(GO:0031985)
0.0 1.2 GO:0016363 nuclear matrix(GO:0016363)
0.1 1.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 361 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 3.4 GO:0017166 vinculin binding(GO:0017166)
0.1 3.2 GO:0070410 co-SMAD binding(GO:0070410)
0.0 2.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 2.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 2.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 1.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.8 GO:0002039 p53 binding(GO:0002039)
0.1 1.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.6 GO:0035064 methylated histone binding(GO:0035064)
0.5 1.5 GO:0004998 transferrin receptor activity(GO:0004998)
0.1 1.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.5 GO:0070888 E-box binding(GO:0070888)
0.0 1.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 1.4 GO:1990405 protein antigen binding(GO:1990405)
0.2 1.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 1.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.2 1.2 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 1.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 1.1 GO:0001972 retinoic acid binding(GO:0001972)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 PID_PLK1_PATHWAY PLK1 signaling events
0.1 3.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 3.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 3.1 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 2.5 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 2.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.8 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.8 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 1.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.5 PID_IFNG_PATHWAY IFN-gamma pathway
0.1 1.3 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.2 1.1 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network
0.1 0.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 2.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.7 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.3 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.2 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.1 1.1 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.1 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 1.1 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 1.1 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions