ISMARA results: Glis3

Motif ID: Glis3

Z-value: 0.487

Transcription factors associated with Glis3:

Gene Symbol	Entrez ID	Gene Name
Glis3	ENSMUSG00000052942.7	Glis3
Glis3	ENSMUSG00000091294.1	Glis3

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Glis3	mm10_v2_chr19_-_28680077_28680122	0.40	1.0e-01	Click!

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr8_-_87959560	1.386	ENSMUST00000109655.2	Zfp423	zinc finger protein 423
chr7_-_49636847	1.340	ENSMUST00000032717.6	Dbx1	developing brain homeobox 1
chr6_+_108660616	1.248	ENSMUST00000032194.4	Bhlhe40	basic helix-loop-helix family, member e40
chr7_-_142899985	1.197	ENSMUST00000000219.3	Th	tyrosine hydroxylase
chr17_-_70851189	1.163	ENSMUST00000059775.8	Tgif1	TGFB-induced factor homeobox 1
chr5_-_24527276	0.729	ENSMUST00000088311.4	Gbx1	gastrulation brain homeobox 1
chr2_-_54085542	0.694	ENSMUST00000100089.2	Rprm	reprimo, TP53 dependent G2 arrest mediator candidate
chr7_+_45017953	0.661	ENSMUST00000044111.7	Rras	Harvey rat sarcoma oncogene, subgroup R
chr3_-_66981279	0.628	ENSMUST00000162098.2	Shox2	short stature homeobox 2
chr4_-_134018829	0.600	ENSMUST00000051674.2	Lin28a	lin-28 homolog A (C. elegans)
chr14_+_62292475	0.582	ENSMUST00000166879.1	Rnaseh2b	ribonuclease H2, subunit B
chr10_+_93641041	0.557	ENSMUST00000020204.4	Ntn4	netrin 4
chr13_-_29984219	0.533	ENSMUST00000146092.1	E2f3	E2F transcription factor 3
chr11_+_101468164	0.524	ENSMUST00000001347.6	Rnd2	Rho family GTPase 2
chrX_-_142966709	0.517	ENSMUST00000041317.2	Ammecr1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr12_+_109743787	0.514	ENSMUST00000183068.1	Mirg	miRNA containing gene
chrM_+_9452	0.506	ENSMUST00000082411.1	mt-Nd3	mitochondrially encoded NADH dehydrogenase 3
chr13_-_40730416	0.458	ENSMUST00000021787.5	Tfap2a	transcription factor AP-2, alpha
chr4_-_41695935	0.446	ENSMUST00000145379.1	Cntfr	ciliary neurotrophic factor receptor
chr13_+_37826225	0.411	ENSMUST00000128570.1	Rreb1	ras responsive element binding protein 1
chr18_-_47368446	0.411	ENSMUST00000076043.6 ENSMUST00000135790.1	Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chrM_+_8600	0.407	ENSMUST00000082409.1	mt-Co3	mitochondrially encoded cytochrome c oxidase III
chr11_-_102317860	0.396	ENSMUST00000107117.2	Ubtf	upstream binding transcription factor, RNA polymerase I
chr16_+_20673517	0.387	ENSMUST00000115460.1	Eif4g1	eukaryotic translation initiation factor 4, gamma 1
chr2_+_131234043	0.372	ENSMUST00000041362.5 ENSMUST00000110199.2	Mavs	mitochondrial antiviral signaling protein
chr11_+_98795495	0.361	ENSMUST00000037915.2	Msl1	male-specific lethal 1 homolog (Drosophila)
chr19_+_46305682	0.331	ENSMUST00000111881.2	Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr7_-_75308373	0.326	ENSMUST00000085164.5	Sv2b	synaptic vesicle glycoprotein 2 b
chr11_+_3289880	0.325	ENSMUST00000110043.1 ENSMUST00000094471.3	Patz1	POZ (BTB) and AT hook containing zinc finger 1
chr11_+_69632927	0.318	ENSMUST00000018909.3	Fxr2	fragile X mental retardation, autosomal homolog 2
chrX_-_23365044	0.306	ENSMUST00000115313.1	Klhl13	kelch-like 13
chr13_+_119428888	0.304	ENSMUST00000026520.7	Paip1	polyadenylate binding protein-interacting protein 1
chr7_-_4812351	0.300	ENSMUST00000079496.7	Ube2s	ubiquitin-conjugating enzyme E2S
chr11_+_97663366	0.297	ENSMUST00000044730.5	Mllt6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr13_+_119428583	0.296	ENSMUST00000109203.2	Paip1	polyadenylate binding protein-interacting protein 1
chr9_+_108306205	0.292	ENSMUST00000007959.8	Rhoa	ras homolog gene family, member A
chr4_+_63215402	0.289	ENSMUST00000036300.6	Col27a1	collagen, type XXVII, alpha 1
chr10_-_13474361	0.288	ENSMUST00000105547.1	Phactr2	phosphatase and actin regulator 2
chr10_+_127739516	0.286	ENSMUST00000054287.7	Zbtb39	zinc finger and BTB domain containing 39
chr6_+_30047979	0.279	ENSMUST00000115212.1 ENSMUST00000123194.1 ENSMUST00000115211.1 ENSMUST00000115206.1 ENSMUST00000133928.1 ENSMUST00000115208.1	Nrf1	nuclear respiratory factor 1
chr1_+_167001457	0.279	ENSMUST00000126198.1	Fam78b	family with sequence similarity 78, member B
chr10_-_7663245	0.260	ENSMUST00000163085.1 ENSMUST00000159917.1	Pcmt1	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chrX_+_101254528	0.259	ENSMUST00000062000.4	Foxo4	forkhead box O4
chr3_+_66981352	0.257	ENSMUST00000162036.1	Rsrc1	arginine/serine-rich coiled-coil 1
chrX_+_101429555	0.254	ENSMUST00000033673.6	Nono	non-POU-domain-containing, octamer binding protein
chr3_+_107595031	0.254	ENSMUST00000014747.1	Alx3	aristaless-like homeobox 3
chr6_+_30048062	0.250	ENSMUST00000115209.1 ENSMUST00000115200.1 ENSMUST00000115204.1	Nrf1	nuclear respiratory factor 1
chr2_+_29890534	0.248	ENSMUST00000113764.3	Odf2	outer dense fiber of sperm tails 2
chr11_-_97187872	0.246	ENSMUST00000001479.4	Kpnb1	karyopherin (importin) beta 1
chr15_+_102407144	0.240	ENSMUST00000169619.1	Sp1	trans-acting transcription factor 1
chr11_-_70237852	0.239	ENSMUST00000108575.2	0610010K14Rik	RIKEN cDNA 0610010K14 gene
chr5_-_115300957	0.232	ENSMUST00000009157.3	Dynll1	dynein light chain LC8-type 1
chr17_+_86963279	0.232	ENSMUST00000139344.1	Rhoq	ras homolog gene family, member Q
chr11_-_115536181	0.230	ENSMUST00000118155.1 ENSMUST00000153892.1	Sumo2	SMT3 suppressor of mif two 3 homolog 2 (yeast)
chr5_-_115300912	0.230	ENSMUST00000112090.1	Dynll1	dynein light chain LC8-type 1
chr19_-_46039621	0.228	ENSMUST00000056931.7	Ldb1	LIM domain binding 1
chr13_+_38345716	0.226	ENSMUST00000171970.1	Bmp6	bone morphogenetic protein 6
chr8_-_88362154	0.219	ENSMUST00000034085.7	Brd7	bromodomain containing 7
chr18_+_34777008	0.218	ENSMUST00000043775.7	Kdm3b	KDM3B lysine (K)-specific demethylase 3B
chr13_+_44730726	0.202	ENSMUST00000173704.1 ENSMUST00000044608.7 ENSMUST00000173367.1	Jarid2	jumonji, AT rich interactive domain 2
chr6_+_108660772	0.201	ENSMUST00000163617.1	Bhlhe40	basic helix-loop-helix family, member e40
chr6_+_17463826	0.200	ENSMUST00000140070.1	Met	met proto-oncogene
chr3_+_121426495	0.197	ENSMUST00000029773.8	Cnn3	calponin 3, acidic
chr11_-_70237886	0.190	ENSMUST00000108577.1 ENSMUST00000108579.1 ENSMUST00000021181.6 ENSMUST00000108578.2 ENSMUST00000102569.3	0610010K14Rik	RIKEN cDNA 0610010K14 gene
chr11_+_98927785	0.185	ENSMUST00000107474.1	Rara	retinoic acid receptor, alpha
chr3_+_89245952	0.179	ENSMUST00000040888.5	Krtcap2	keratinocyte associated protein 2
chr11_-_69920892	0.179	ENSMUST00000152589.1 ENSMUST00000108612.1 ENSMUST00000108611.1	Eif5a	eukaryotic translation initiation factor 5A
chr7_-_142657466	0.173	ENSMUST00000097936.2 ENSMUST00000000033.5	Igf2	insulin-like growth factor 2
chr14_-_62292959	0.163	ENSMUST00000063169.8	Dleu7	deleted in lymphocytic leukemia, 7
chr19_-_6987621	0.162	ENSMUST00000130048.1 ENSMUST00000025914.6	Vegfb	vascular endothelial growth factor B
chr3_+_89246397	0.162	ENSMUST00000168900.1	Krtcap2	keratinocyte associated protein 2
chr16_+_20673264	0.158	ENSMUST00000154950.1 ENSMUST00000115461.1	Eif4g1	eukaryotic translation initiation factor 4, gamma 1
chr7_+_127485221	0.152	ENSMUST00000048896.6	Fbrs	fibrosin
chr4_+_118428078	0.152	ENSMUST00000006557.6 ENSMUST00000167636.1 ENSMUST00000102673.4	Elovl1	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr11_-_70237638	0.150	ENSMUST00000100950.3	0610010K14Rik	RIKEN cDNA 0610010K14 gene
chr14_+_54640952	0.148	ENSMUST00000169818.2	Gm17606	predicted gene, 17606
chr1_-_93445642	0.139	ENSMUST00000042498.7	Hdlbp	high density lipoprotein (HDL) binding protein
chr15_-_85581809	0.139	ENSMUST00000023015.7	Wnt7b	wingless-related MMTV integration site 7B
chr11_-_115535804	0.137	ENSMUST00000117589.1 ENSMUST00000121185.1	Sumo2	SMT3 suppressor of mif two 3 homolog 2 (yeast)
chr17_+_80944611	0.137	ENSMUST00000025092.4	Tmem178	transmembrane protein 178
chr11_-_70237761	0.133	ENSMUST00000108576.3	0610010K14Rik	RIKEN cDNA 0610010K14 gene
chr7_-_4778141	0.133	ENSMUST00000094892.5	Il11	interleukin 11
chr15_+_102406143	0.129	ENSMUST00000170884.1 ENSMUST00000165924.1 ENSMUST00000163709.1 ENSMUST00000001326.6	Sp1	trans-acting transcription factor 1
chr9_-_108305941	0.117	ENSMUST00000044725.7	Tcta	T cell leukemia translocation altered gene
chr5_+_110135823	0.107	ENSMUST00000112519.2 ENSMUST00000014812.8	Chfr	checkpoint with forkhead and ring finger domains
chr11_-_52000432	0.103	ENSMUST00000020657.6	Ube2b	ubiquitin-conjugating enzyme E2B
chr7_+_90442729	0.099	ENSMUST00000061767.4 ENSMUST00000107206.1	Crebzf	CREB/ATF bZIP transcription factor
chrX_-_94542037	0.097	ENSMUST00000026142.7	Maged1	melanoma antigen, family D, 1
chr7_+_25282179	0.094	ENSMUST00000163320.1 ENSMUST00000005578.6	Cic	capicua homolog (Drosophila)
chr17_-_23745829	0.090	ENSMUST00000046525.8	Kremen2	kringle containing transmembrane protein 2
chr17_-_34031684	0.086	ENSMUST00000169397.1	Slc39a7	solute carrier family 39 (zinc transporter), member 7
chr3_-_142881942	0.076	ENSMUST00000043812.8	Pkn2	protein kinase N2
chr2_-_156111863	0.071	ENSMUST00000154889.1 ENSMUST00000079312.3 ENSMUST00000153634.1 ENSMUST00000133921.1 ENSMUST00000184265.1 ENSMUST00000109607.3 ENSMUST00000109608.2 ENSMUST00000131377.1 ENSMUST00000183518.1	Cpne1 Rbm12 RP23-220D12.12	copine I RNA binding motif protein 12 RNA-binding protein 12
chr17_-_65613521	0.071	ENSMUST00000024897.8	Vapa	vesicle-associated membrane protein, associated protein A
chr11_-_100619576	0.065	ENSMUST00000155152.1	Dnajc7	DnaJ (Hsp40) homolog, subfamily C, member 7
chr4_+_137993445	0.062	ENSMUST00000105831.2 ENSMUST00000084214.5	Eif4g3	eukaryotic translation initiation factor 4 gamma, 3
chr11_-_52000748	0.061	ENSMUST00000109086.1	Ube2b	ubiquitin-conjugating enzyme E2B
chr11_+_77982710	0.059	ENSMUST00000108360.1 ENSMUST00000049167.7	Phf12	PHD finger protein 12
chr7_+_127746775	0.053	ENSMUST00000033081.7	Fbxl19	F-box and leucine-rich repeat protein 19
chrX_-_38564519	0.052	ENSMUST00000016681.8	Cul4b	cullin 4B
chr2_-_119477613	0.049	ENSMUST00000110808.1 ENSMUST00000049920.7	Ino80	INO80 homolog (S. cerevisiae)
chr11_+_77493408	0.048	ENSMUST00000037285.3 ENSMUST00000100812.3	Git1	G protein-coupled receptor kinase-interactor 1
chr19_+_8941865	0.046	ENSMUST00000096240.2	Mta2	metastasis-associated gene family, member 2
chr11_+_5861886	0.038	ENSMUST00000102923.3	Aebp1	AE binding protein 1
chr6_+_88198656	0.032	ENSMUST00000015197.7	Gata2	GATA binding protein 2
chr11_+_100619217	0.026	ENSMUST00000107376.1	Nkiras2	NFKB inhibitor interacting Ras-like protein 2
chr2_-_156111954	0.021	ENSMUST00000142960.2 ENSMUST00000136296.2 ENSMUST00000059647.5 ENSMUST00000109604.2 ENSMUST00000138068.1 ENSMUST00000128499.1	Cpne1 Rbm12	copine I RNA binding motif protein 12
chrX_-_135009185	0.017	ENSMUST00000113185.2 ENSMUST00000064659.5	Zmat1	zinc finger, matrin type 1
chr7_+_3332918	0.016	ENSMUST00000092891.4	Cacng7	calcium channel, voltage-dependent, gamma subunit 7
chr17_-_34031544	0.016	ENSMUST00000025186.8	Slc39a7	solute carrier family 39 (zinc transporter), member 7
chrX_+_151522352	0.014	ENSMUST00000148622.1	Phf8	PHD finger protein 8
chr1_+_167001417	0.012	ENSMUST00000165874.1	Fam78b	family with sequence similarity 78, member B
chr17_-_34031644	0.009	ENSMUST00000171872.1	Slc39a7	solute carrier family 39 (zinc transporter), member 7
chr8_+_70863127	0.003	ENSMUST00000050921.2	A230052G05Rik	RIKEN cDNA A230052G05 gene
chr7_-_16286744	0.000	ENSMUST00000150528.2 ENSMUST00000118976.2 ENSMUST00000146609.2	Ccdc9	coiled-coil domain containing 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.2	GO:0042414	epinephrine metabolic process(GO:0042414)
0.2	0.7	GO:0097374	sensory neuron axon guidance(GO:0097374)
0.2	0.5	GO:0070172	oculomotor nerve development(GO:0021557) positive regulation of tooth mineralization(GO:0070172)
0.1	0.4	GO:0071649	regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.1	0.4	GO:0003360	brainstem development(GO:0003360)
0.1	0.6	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.1	0.3	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.1	0.3	GO:2001160	regulation of histone H3-K79 methylation(GO:2001160)
0.1	0.3	GO:0003100	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.1	0.6	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.1	0.2	GO:0048146	positive regulation of fibroblast proliferation(GO:0048146)
0.1	0.6	GO:0010587	miRNA catabolic process(GO:0010587)
0.1	1.3	GO:0021521	ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1	0.6	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.1	0.2	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.1	0.2	GO:0060010	Sertoli cell fate commitment(GO:0060010)
0.1	0.2	GO:0043973	histone H3-K4 acetylation(GO:0043973)
0.1	1.2	GO:0038092	nodal signaling pathway(GO:0038092)
0.1	0.2	GO:0010845	positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1	0.4	GO:0070814	hydrogen sulfide biosynthetic process(GO:0070814)
0.0	1.4	GO:0043153	entrainment of circadian clock by photoperiod(GO:0043153)
0.0	0.3	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.1	GO:0072061	establishment or maintenance of polarity of embryonic epithelium(GO:0016332) inner medullary collecting duct development(GO:0072061)
0.0	0.4	GO:2000394	positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0	0.5	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.0	0.4	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.5	GO:2000580	positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0	0.2	GO:0035470	positive regulation of vascular wound healing(GO:0035470)
0.0	0.2	GO:0032346	positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.0	0.2	GO:0072718	response to cisplatin(GO:0072718)
0.0	0.3	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0	0.5	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
0.0	0.3	GO:0070317	negative regulation of smooth muscle cell differentiation(GO:0051151) negative regulation of G0 to G1 transition(GO:0070317)
0.0	1.2	GO:0030513	positive regulation of BMP signaling pathway(GO:0030513)
0.0	0.2	GO:0006452	translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0	0.6	GO:2000001	regulation of DNA damage checkpoint(GO:2000001)
0.0	0.5	GO:0051602	response to electrical stimulus(GO:0051602)
0.0	0.2	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	0.4	GO:2001224	positive regulation of neuron migration(GO:2001224)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0	0.3	GO:0018195	peptidyl-arginine modification(GO:0018195)
0.0	0.3	GO:0002467	germinal center formation(GO:0002467)
0.0	0.1	GO:0060903	positive regulation of meiosis I(GO:0060903)
0.0	0.2	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.0	0.2	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.4	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.0	0.3	GO:0046498	S-adenosylhomocysteine metabolic process(GO:0046498)
0.0	0.4	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.5	GO:0071385	cellular response to glucocorticoid stimulus(GO:0071385)
0.0	0.1	GO:0044828	negative regulation by host of viral genome replication(GO:0044828)
0.0	0.2	GO:0019368	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.3	GO:0035115	embryonic forelimb morphogenesis(GO:0035115)
0.0	0.1	GO:0070494	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.2	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1	0.4	GO:0097059	CNTFR-CLCF1 complex(GO:0097059)
0.1	0.6	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.1	0.4	GO:0072487	MSL complex(GO:0072487)
0.1	0.5	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1	0.7	GO:0016589	NURF complex(GO:0016589)
0.0	0.3	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.3	GO:0042382	paraspeckles(GO:0042382)
0.0	0.5	GO:1904115	axon cytoplasm(GO:1904115)
0.0	0.3	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.2	GO:0033503	HULC complex(GO:0033503)
0.0	0.3	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.2	GO:0097539	ciliary transition fiber(GO:0097539)
0.0	0.2	GO:0005642	annulate lamellae(GO:0005642)
0.0	0.3	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	0.5	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.4	GO:0043426	MRF binding(GO:0043426)
0.2	1.2	GO:0035240	dopamine binding(GO:0035240)
0.1	0.6	GO:0008494	translation activator activity(GO:0008494)
0.1	0.6	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1	0.4	GO:0001165	RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.1	0.4	GO:0050700	CARD domain binding(GO:0050700)
0.1	0.4	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.1	0.6	GO:0043237	laminin-1 binding(GO:0043237)
0.1	0.6	GO:0002151	G-quadruplex RNA binding(GO:0002151)
0.1	0.2	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1	1.2	GO:0070410	co-SMAD binding(GO:0070410)
0.1	0.3	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.5	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.5	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.1	GO:1902379	chemoattractant activity involved in axon guidance(GO:1902379)
0.0	0.3	GO:0051022	Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0	0.2	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.4	GO:0031386	protein tag(GO:0031386)
0.0	0.3	GO:0004576	oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.4	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.4	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.1	GO:0005008	hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.5	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.2	GO:0035014	phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0	0.5	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	0.2	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.4	GO:0071837	HMG box domain binding(GO:0071837)
0.0	0.2	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0	0.2	GO:0017070	U6 snRNA binding(GO:0017070)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	PID_CIRCADIAN_PATHWAY	Circadian rhythm pathway
0.0	1.2	PID_P38_MK2_PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.3	PID_THROMBIN_PAR4_PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.7	PID_RAS_PATHWAY	Regulation of Ras family activation
0.0	0.2	PID_SMAD2_3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.2	PID_VEGF_VEGFR_PATHWAY	VEGF and VEGFR signaling network
0.0	1.3	PID_AR_PATHWAY	Coregulation of Androgen receptor activity
0.0	1.5	PID_MYC_ACTIV_PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	0.4	PID_FRA_PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	0.2	PID_INSULIN_GLUCOSE_PATHWAY	Insulin-mediated glucose transport
0.0	0.2	PID_HDAC_CLASSIII_PATHWAY	Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME_AMINE_DERIVED_HORMONES	Genes involved in Amine-derived hormones
0.0	0.5	REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.0	0.7	REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	1.1	REACTOME_DEADENYLATION_OF_MRNA	Genes involved in Deadenylation of mRNA
0.0	1.5	REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	1.4	REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.7	REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.5	REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.2	REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.4	REACTOME_OTHER_SEMAPHORIN_INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.2	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.1	REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.2	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.3	REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION	Genes involved in RNA Polymerase I Transcription Termination