Motif ID: Creb3l2

Z-value: 0.639


Transcription factors associated with Creb3l2:

Gene SymbolEntrez IDGene Name
Creb3l2 ENSMUSG00000038648.5 Creb3l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3l2mm10_v2_chr6_-_37442095_37442154-0.437.4e-02Click!


Activity profile for motif Creb3l2.

activity profile for motif Creb3l2


Sorted Z-values histogram for motif Creb3l2

Sorted Z-values for motif Creb3l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb3l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 155 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_30945393 2.634 ENSMUST00000031051.6
 Cgref1
cell growth regulator with EF hand domain 1
chr2_+_84840612 1.966 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chrX_+_50841434 1.859 ENSMUST00000114887.2
 2610018G03Rik
RIKEN cDNA 2610018G03 gene
chr9_-_43239816 1.856 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr15_+_34238026 1.851 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr7_+_19094594 1.822 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr5_-_135251209 1.693 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr2_-_105399286 1.623 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr16_-_78376758 1.376 ENSMUST00000023570.7
 Btg3
B cell translocation gene 3
chr11_-_94653964 1.362 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr10_+_13090788 1.263 ENSMUST00000121646.1
ENSMUST00000121325.1
ENSMUST00000121766.1
 Plagl1


pleiomorphic adenoma gene-like 1


chr19_-_4201591 1.211 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr7_-_25250720 1.189 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr15_-_34495180 1.078 ENSMUST00000022946.5
 Hrsp12
heat-responsive protein 12
chr3_-_20155069 1.049 ENSMUST00000184552.1
ENSMUST00000178328.1
 Gyg

glycogenin

chr10_+_20148920 0.989 ENSMUST00000116259.3
 Map7
microtubule-associated protein 7
chr2_-_92370999 0.982 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr15_+_79516396 0.981 ENSMUST00000010974.7
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr12_+_17544873 0.884 ENSMUST00000171737.1
 Odc1
ornithine decarboxylase, structural 1
chr6_-_83317589 0.865 ENSMUST00000005810.6
 Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0007050 cell cycle arrest(GO:0007050)
0.1 1.8 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.6 1.7 GO:1990523 bone regeneration(GO:1990523)
0.0 1.5 GO:0015804 neutral amino acid transport(GO:0015804)
0.3 1.4 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.2 1.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 1.3 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 1.3 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 1.2 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.1 1.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.3 0.9 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.2 0.9 GO:0006526 arginine biosynthetic process(GO:0006526)
0.3 0.8 GO:0006097 glyoxylate cycle(GO:0006097) negative regulation of glial cell migration(GO:1903976)
0.2 0.8 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.1 0.8 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 0.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 0.7 GO:0002725 negative regulation of T cell cytokine production(GO:0002725)
0.2 0.7 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 0.7 GO:1903416 response to glycoside(GO:1903416)
0.1 0.6 GO:2000680 regulation of rubidium ion transport(GO:2000680)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0031527 filopodium membrane(GO:0031527)
0.0 1.5 GO:0015934 large ribosomal subunit(GO:0015934)
0.3 1.4 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 1.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 1.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.7 GO:0016342 catenin complex(GO:0016342)
0.0 0.7 GO:0035102 PRC1 complex(GO:0035102)
0.2 0.6 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 0.6 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.1 0.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 0.5 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.5 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.4 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.3 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.3 1.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.2 1.4 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.3 1.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 1.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 1.0 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.3 0.9 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.2 0.9 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.3 0.8 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.8 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.1 0.7 GO:1990239 steroid hormone binding(GO:1990239)
0.1 0.7 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 0.6 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.6 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.6 GO:0070182 DNA polymerase binding(GO:0070182)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 1.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.7 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.4 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.3 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.4 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.2 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 1.0 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.9 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.9 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 0.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport