Motif ID: Junb_Jund

Z-value: 1.420

Transcription factors associated with Junb_Jund:

Gene SymbolEntrez IDGene Name
Junb ENSMUSG00000052837.5 Junb
Jund ENSMUSG00000071076.5 Jund

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Junbmm10_v2_chr8_-_84978709_849787480.484.3e-02Click!
Jundmm10_v2_chr8_+_70697739_70697739-0.272.8e-01Click!


Activity profile for motif Junb_Jund.

activity profile for motif Junb_Jund


Sorted Z-values histogram for motif Junb_Jund

Sorted Z-values for motif Junb_Jund



Network of associatons between targets according to the STRING database.



First level regulatory network of Junb_Jund

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_54681687 9.892 ENSMUST00000046276.6
 2410066E13Rik
RIKEN cDNA 2410066E13 gene
chr9_-_98032983 6.912 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr9_-_98033181 6.123 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr13_-_54688264 6.100 ENSMUST00000150626.1
ENSMUST00000134177.1
 Rnf44

ring finger protein 44

chr7_-_142095266 5.968 ENSMUST00000039926.3
 Dusp8
dual specificity phosphatase 8
chr7_+_54835959 5.197 ENSMUST00000082373.6
 Luzp2
leucine zipper protein 2
chr2_+_155276297 5.123 ENSMUST00000029128.3
 Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr14_+_66344369 5.000 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
 Stmn4



stathmin-like 4



chr14_+_66344296 4.992 ENSMUST00000152093.1
ENSMUST00000074523.6
 Stmn4

stathmin-like 4

chr10_-_17947997 4.335 ENSMUST00000037879.6
 Heca
headcase homolog (Drosophila)
chr13_-_54688246 4.287 ENSMUST00000122935.1
ENSMUST00000128257.1
 Rnf44

ring finger protein 44

chr7_+_112679327 3.863 ENSMUST00000106638.2
 Tead1
TEA domain family member 1
chr11_+_83302817 3.714 ENSMUST00000142680.1
 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr6_-_124464772 3.201 ENSMUST00000008297.4
 Clstn3
calsyntenin 3
chr11_+_83302641 3.164 ENSMUST00000176430.1
ENSMUST00000065692.7
 Ap2b1

adaptor-related protein complex 2, beta 1 subunit

chr18_-_35215008 3.090 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr11_+_103101682 3.052 ENSMUST00000107040.3
ENSMUST00000140372.1
ENSMUST00000024492.8
ENSMUST00000134884.1
 Acbd4



acyl-Coenzyme A binding domain containing 4



chr11_+_79660532 3.048 ENSMUST00000155381.1
 Rab11fip4
RAB11 family interacting protein 4 (class II)
chr4_+_21931291 2.970 ENSMUST00000029908.7
 Faxc
failed axon connections homolog (Drosophila)
chr9_+_40269273 2.950 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 275 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 10.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.9 7.9 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.5 6.6 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.3 5.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.6 5.8 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.5 5.2 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.5 4.7 GO:0098907 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
0.2 4.7 GO:0001553 luteinization(GO:0001553)
0.0 4.5 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161)
0.2 4.2 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.2 4.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.4 3.8 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.2 3.8 GO:0061000 negative regulation of dendritic spine development(GO:0061000)
1.2 3.7 GO:0045204 MAPK export from nucleus(GO:0045204)
0.3 3.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.5 3.4 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 3.4 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 3.3 GO:0071625 vocalization behavior(GO:0071625)
0.6 3.2 GO:0051012 microtubule sliding(GO:0051012)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 36.5 GO:0060076 excitatory synapse(GO:0060076)
0.1 10.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 8.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.3 8.1 GO:0031430 M band(GO:0031430)
0.0 7.7 GO:0043005 neuron projection(GO:0043005)
0.2 7.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.4 5.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 5.1 GO:0044754 autolysosome(GO:0044754)
0.1 5.0 GO:0005776 autophagosome(GO:0005776)
1.1 4.5 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 4.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 4.0 GO:0001650 fibrillar center(GO:0001650)
0.0 3.9 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.4 GO:0008021 synaptic vesicle(GO:0008021)
0.2 3.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 3.0 GO:0031901 early endosome membrane(GO:0031901)
0.6 2.8 GO:0032437 cuticular plate(GO:0032437)
0.3 2.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 2.8 GO:0043204 perikaryon(GO:0043204)
0.0 2.7 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.0 GO:0015631 tubulin binding(GO:0015631)
0.0 18.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 10.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 9.0 GO:0030276 clathrin binding(GO:0030276)
0.1 7.0 GO:0030507 spectrin binding(GO:0030507)
0.3 6.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.8 6.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 6.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.8 5.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 5.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 4.8 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.3 4.7 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.2 4.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 4.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 4.2 GO:0030552 cAMP binding(GO:0030552)
0.0 4.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 3.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 3.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.4 3.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.3 3.7 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 5.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 4.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 3.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 3.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.1 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.7 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 2.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 2.1 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 1.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.8 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 1.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.7 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.4 ST_GA13_PATHWAY G alpha 13 Pathway
0.1 1.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 1.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 1.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 1.2 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 10.3 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 4.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 4.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 4.2 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.2 4.2 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 2.9 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.2 2.5 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 2.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 2.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.2 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 2.2 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.0 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.6 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 1.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 1.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway