ISMARA results: Runx2

Motif ID: Runx2_Bcl11a

Z-value: 0.987

Transcription factors associated with Runx2_Bcl11a:

Gene Symbol	Entrez ID	Gene Name
Bcl11a	ENSMUSG00000000861.9	Bcl11a
Runx2	ENSMUSG00000039153.10	Runx2

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Bcl11a	mm10_v2_chr11_+_24078022_24078076	0.24	3.4e-01	Click!

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Top targets:

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Showing 1 to 20 of 200 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr8_-_11008458	2.050	ENSMUST00000040514.6	Irs2	insulin receptor substrate 2
chr1_-_169747634	1.431	ENSMUST00000027991.5 ENSMUST00000111357.1	Rgs4	regulator of G-protein signaling 4
chrX_+_159697308	1.236	ENSMUST00000123433.1	Sh3kbp1	SH3-domain kinase binding protein 1
chr17_+_88626549	1.225	ENSMUST00000163588.1 ENSMUST00000064035.6	Ston1	stonin 1
chr15_-_66801577	1.190	ENSMUST00000168589.1	Sla	src-like adaptor
chr1_+_165302625	1.119	ENSMUST00000111450.1	Gpr161	G protein-coupled receptor 161
chr10_+_61171954	1.022	ENSMUST00000122261.1 ENSMUST00000121297.1 ENSMUST00000035894.5	Tbata	thymus, brain and testes associated
chr3_-_88000350	0.938	ENSMUST00000090971.5	Bcan	brevican
chr1_+_58210397	0.908	ENSMUST00000040442.5	Aox4	aldehyde oxidase 4
chr9_+_54764748	0.904	ENSMUST00000034830.8	Crabp1	cellular retinoic acid binding protein I
chr11_+_3330781	0.899	ENSMUST00000136536.1 ENSMUST00000093399.4	Pik3ip1	phosphoinositide-3-kinase interacting protein 1
chr4_+_133176336	0.881	ENSMUST00000105912.1	Wasf2	WAS protein family, member 2
chr9_-_103219823	0.848	ENSMUST00000168142.1	Trf	transferrin
chr13_+_76579670	0.839	ENSMUST00000126960.1 ENSMUST00000109583.2	Mctp1	multiple C2 domains, transmembrane 1
chr17_+_75178797	0.821	ENSMUST00000112516.1 ENSMUST00000135447.1	Ltbp1	latent transforming growth factor beta binding protein 1
chr2_+_31759993	0.789	ENSMUST00000124089.1	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase
chr15_-_100584075	0.761	ENSMUST00000184908.1	POU6F1	POU domain, class 6, transcription factor 1 (Pou6f1), mRNA
chr4_+_48049080	0.744	ENSMUST00000153369.1	Nr4a3	nuclear receptor subfamily 4, group A, member 3
chr11_+_80183851	0.730	ENSMUST00000017839.2	Rnf135	ring finger protein 135
chr6_-_126645784	0.729	ENSMUST00000055168.3	Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.0	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.2	1.7	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1	1.5	GO:0032967	positive regulation of collagen biosynthetic process(GO:0032967)
0.2	1.1	GO:1901731	positive regulation of platelet aggregation(GO:1901731)
0.1	1.1	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0	1.1	GO:0072673	lamellipodium morphogenesis(GO:0072673)
0.0	1.1	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	1.1	GO:0015807	L-amino acid transport(GO:0015807)
0.0	1.1	GO:0021766	hippocampus development(GO:0021766)
0.0	1.0	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3	0.9	GO:1900275	negative regulation of phospholipase C activity(GO:1900275)
0.3	0.9	GO:0046110	xanthine metabolic process(GO:0046110)
0.3	0.9	GO:0016115	terpenoid catabolic process(GO:0016115)
0.3	0.9	GO:0050975	sensory perception of touch(GO:0050975)
0.1	0.9	GO:0042572	retinol metabolic process(GO:0042572)
0.1	0.9	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.9	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1	0.8	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.0	0.8	GO:1901998	toxin transport(GO:1901998)
0.2	0.7	GO:0038095	positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	GO:0043204	perikaryon(GO:0043204)
0.0	1.6	GO:0055037	recycling endosome(GO:0055037)
0.5	1.5	GO:0038045	large latent transforming growth factor-beta complex(GO:0038045)
0.0	1.4	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	1.2	GO:0042641	actomyosin(GO:0042641)
0.1	1.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.1	0.9	GO:0031209	SCAR complex(GO:0031209)
0.1	0.8	GO:0097433	dense body(GO:0097433)
0.0	0.8	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.2	0.7	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.7	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.6	GO:0043235	receptor complex(GO:0043235)
0.1	0.5	GO:0060187	cell pole(GO:0060187)
0.1	0.5	GO:1990246	uniplex complex(GO:1990246)
0.1	0.5	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.5	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	0.5	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.5	GO:0000930	gamma-tubulin complex(GO:0000930)
0.1	0.4	GO:1903440	calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1	0.4	GO:0070826	paraferritin complex(GO:0070826)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 143 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	GO:0005158	insulin receptor binding(GO:0005158)
0.0	2.3	GO:0017124	SH3 domain binding(GO:0017124)
0.5	1.6	GO:0036313	phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.4	1.6	GO:0050436	microfibril binding(GO:0050436)
0.0	1.5	GO:0015175	neutral amino acid transmembrane transporter activity(GO:0015175)
0.0	1.4	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.1	1.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	1.2	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.1	1.1	GO:0015250	water channel activity(GO:0015250)
0.0	1.1	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0	1.0	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.2	0.9	GO:0030151	molybdenum ion binding(GO:0030151)
0.2	0.9	GO:0019841	retinol binding(GO:0019841)
0.1	0.9	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1	0.9	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.1	0.9	GO:0070097	delta-catenin binding(GO:0070097)
0.1	0.9	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.8	GO:0015091	ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0	0.8	GO:0030507	spectrin binding(GO:0030507)
0.2	0.7	GO:0031721	haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	PID_IGF1_PATHWAY	IGF1 pathway
0.0	2.0	PID_TRKR_PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	1.9	NABA_ECM_GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	1.6	PID_ERBB1_INTERNALIZATION_PATHWAY	Internalization of ErbB1
0.0	1.3	PID_ECADHERIN_NASCENT_AJ_PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	1.1	PID_NETRIN_PATHWAY	Netrin-mediated signaling events
0.0	1.0	PID_PDGFRB_PATHWAY	PDGFR-beta signaling pathway
0.0	0.8	PID_HDAC_CLASSII_PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.8	PID_ERA_GENOMIC_PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.7	ST_GA12_PATHWAY	G alpha 12 Pathway
0.0	0.7	PID_TAP63_PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.7	NABA_PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.6	PID_PI3K_PLC_TRK_PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	0.6	PID_AP1_PATHWAY	AP-1 transcription factor network
0.0	0.5	PID_ANTHRAX_PATHWAY	Cellular roles of Anthrax toxin
0.0	0.5	PID_S1P_META_PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	0.4	PID_ARF6_DOWNSTREAM_PATHWAY	Arf6 downstream pathway
0.0	0.4	PID_AJDISS_2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.4	PID_NOTCH_PATHWAY	Notch signaling pathway
0.0	0.3	PID_RET_PATHWAY	Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 20 of 46 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	REACTOME_SIGNAL_ATTENUATION	Genes involved in Signal attenuation
0.0	1.4	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	1.2	REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	1.2	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	1.1	REACTOME_CS_DS_DEGRADATION	Genes involved in CS/DS degradation
0.0	1.1	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	1.1	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	Genes involved in G alpha (z) signalling events
0.0	1.0	REACTOME_SIGNALING_BY_ROBO_RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	0.9	REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.9	REACTOME_CGMP_EFFECTS	Genes involved in cGMP effects
0.1	0.8	REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.7	REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.6	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.6	REACTOME_DAG_AND_IP3_SIGNALING	Genes involved in DAG and IP3 signaling
0.0	0.5	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.5	REACTOME_NETRIN1_SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.5	REACTOME_DARPP_32_EVENTS	Genes involved in DARPP-32 events
0.1	0.4	REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.1	0.4	REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.4	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)