Motif ID: Tlx2
Z-value: 0.811
Transcription factors associated with Tlx2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tlx2 | ENSMUSG00000068327.3 | Tlx2 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 181 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.2 | GO:1902715 | positive regulation of interferon-gamma secretion(GO:1902715) |
| 0.8 | 3.1 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 0.0 | 1.9 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.6 | 1.8 | GO:2000435 | regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
| 0.0 | 1.7 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.4 | 1.6 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
| 0.0 | 1.6 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.0 | 1.5 | GO:0010921 | regulation of phosphatase activity(GO:0010921) |
| 0.0 | 1.4 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
| 0.0 | 1.4 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.2 | 1.3 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.2 | 1.3 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.0 | 1.2 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.4 | 1.1 | GO:0090187 | zymogen granule exocytosis(GO:0070625) positive regulation of pancreatic juice secretion(GO:0090187) |
| 0.1 | 1.1 | GO:0046645 | positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474) |
| 0.1 | 1.1 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.0 | 1.1 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.0 | 1.1 | GO:0051591 | response to cAMP(GO:0051591) |
| 0.1 | 1.0 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.1 | 1.0 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 81 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.7 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 1.9 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.2 | 1.7 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 1.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 1.5 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 1.5 | GO:0022627 | small ribosomal subunit(GO:0015935) cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 1.3 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 1.1 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.1 | 1.1 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 1.1 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 1.0 | GO:0002177 | manchette(GO:0002177) |
| 0.1 | 1.0 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.2 | 0.9 | GO:0071942 | XPC complex(GO:0071942) |
| 0.0 | 0.9 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 0.8 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.8 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.8 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.2 | 0.7 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.1 | 0.7 | GO:0042612 | MHC class I protein complex(GO:0042612) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 114 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 3.2 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 3.1 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.1 | 2.2 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.3 | 1.8 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.2 | 1.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 1.5 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.1 | 1.4 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 1.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 1.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 1.2 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 0.2 | 1.1 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.2 | 1.1 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.2 | 1.1 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.1 | 1.1 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 1.1 | GO:0031628 | opioid receptor binding(GO:0031628) |
| 0.0 | 1.1 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 1.0 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.1 | 1.0 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.0 | 0.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 23 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.7 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 1.6 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.4 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.4 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 1.2 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.8 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.1 | 0.7 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
| 0.0 | 0.6 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.5 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.5 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 0.5 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.5 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 0.4 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.4 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.4 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 0.4 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.3 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.3 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.0 | 0.2 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 53 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.4 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 3.4 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 1.6 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 1.3 | REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 1.3 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 1.2 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 1.1 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 1.1 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 0.8 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 0.8 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.8 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 0.8 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 0.7 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 0.7 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.7 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.7 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.7 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.7 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.7 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.7 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
