Motif ID: Gbx1_Nobox_Alx3

Z-value: 0.601

Transcription factors associated with Gbx1_Nobox_Alx3:

Gene SymbolEntrez IDGene Name
Alx3 ENSMUSG00000014603.1 Alx3
Gbx1 ENSMUSG00000067724.4 Gbx1
Nobox ENSMUSG00000029736.9 Nobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx3mm10_v2_chr3_+_107595031_107595164-0.626.0e-03Click!
Gbx1mm10_v2_chr5_-_24527276_245272760.351.6e-01Click!


Activity profile for motif Gbx1_Nobox_Alx3.

activity profile for motif Gbx1_Nobox_Alx3


Sorted Z-values histogram for motif Gbx1_Nobox_Alx3

Sorted Z-values for motif Gbx1_Nobox_Alx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx1_Nobox_Alx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_143933089 2.203 ENSMUST00000087313.3
 Dcx
doublecortin
chr12_+_38780284 2.022 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr15_+_25773985 2.021 ENSMUST00000125667.1
 Myo10
myosin X
chr10_+_127421208 1.831 ENSMUST00000168780.1
 R3hdm2
R3H domain containing 2
chr11_-_98053415 1.678 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr12_+_38780817 1.573 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr12_+_38781093 1.357 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr1_-_158356258 1.309 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr18_+_23415400 1.249 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr3_+_62419668 1.199 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr4_+_108719649 1.120 ENSMUST00000178992.1
 3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr5_+_121777929 1.058 ENSMUST00000160821.1
 Atxn2
ataxin 2
chr1_+_72284367 1.037 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr12_-_91849081 1.034 ENSMUST00000167466.1
ENSMUST00000021347.5
ENSMUST00000178462.1
 Sel1l


sel-1 suppressor of lin-12-like (C. elegans)


chr1_-_155417394 1.014 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr18_-_80986578 0.980 ENSMUST00000057950.7
 Sall3
sal-like 3 (Drosophila)
chr16_+_33684538 0.965 ENSMUST00000126532.1
 Heg1
HEG homolog 1 (zebrafish)
chr9_+_32116040 0.940 ENSMUST00000174641.1
 Arhgap32
Rho GTPase activating protein 32
chr2_+_109917639 0.935 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr2_+_69897255 0.931 ENSMUST00000131553.1
 Ubr3
ubiquitin protein ligase E3 component n-recognin 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.7 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 2.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 2.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 2.0 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 1.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.3 1.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 1.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.2 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.1 1.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 1.1 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.3 1.0 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 1.0 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 1.0 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 1.0 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 1.0 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 1.0 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 1.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.3 0.9 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.9 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0030426 growth cone(GO:0030426)
0.1 2.6 GO:0031672 A band(GO:0031672)
0.0 1.8 GO:0016459 myosin complex(GO:0016459)
0.1 1.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 1.0 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 1.0 GO:0005844 polysome(GO:0005844)
0.1 0.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.9 GO:0071565 nBAF complex(GO:0071565)
0.2 0.7 GO:0060187 cell pole(GO:0060187)
0.1 0.6 GO:0031523 Myb complex(GO:0031523)
0.0 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.6 GO:0005882 intermediate filament(GO:0005882)
0.0 0.6 GO:0031594 neuromuscular junction(GO:0031594)
0.1 0.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.5 GO:0005915 zonula adherens(GO:0005915)
0.0 0.5 GO:1990752 microtubule plus-end(GO:0035371) microtubule end(GO:1990752)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.5 GO:0097440 apical dendrite(GO:0097440)
0.1 0.4 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.4 GO:0097524 sperm plasma membrane(GO:0097524)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0008017 microtubule binding(GO:0008017)
0.1 3.0 GO:0030507 spectrin binding(GO:0030507)
0.2 2.4 GO:0050692 DBD domain binding(GO:0050692)
0.2 1.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.3 1.0 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 0.9 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.9 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.8 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 0.8 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 0.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.6 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 0.6 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 0.6 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.1 0.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.6 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.6 GO:0043495 protein anchor(GO:0043495)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 0.8 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.4 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.3 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.2 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 2.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 0.9 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 0.9 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.8 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.8 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.6 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 0.5 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.3 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated