Motif ID: Hmga1

Z-value: 0.987


Transcription factors associated with Hmga1:

Gene SymbolEntrez IDGene Name
Hmga1 ENSMUSG00000046711.9 Hmga1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmga1mm10_v2_chr17_+_27556668_275566900.653.5e-03Click!


Activity profile for motif Hmga1.

activity profile for motif Hmga1


Sorted Z-values histogram for motif Hmga1

Sorted Z-values for motif Hmga1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmga1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 8.216 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr18_+_20665250 7.876 ENSMUST00000075312.3
 Ttr
transthyretin
chr14_-_48667508 2.859 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr17_+_85620816 2.758 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr3_+_102010138 2.362 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr8_-_87959560 2.334 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr1_+_45311538 2.147 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr16_-_26989974 2.051 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr17_+_43953191 2.011 ENSMUST00000044792.4
 Rcan2
regulator of calcineurin 2
chr10_+_4611971 1.786 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr10_+_97482350 1.547 ENSMUST00000163448.2
 Dcn
decorin
chr17_+_43952999 1.514 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr3_-_88577208 1.418 ENSMUST00000098952.2
 Gm10704
predicted pseudogene 10704
chr10_-_92165159 1.377 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr9_-_100506844 1.377 ENSMUST00000112874.3
 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr10_+_97565436 1.371 ENSMUST00000038160.4
 Lum
lumican
chr12_-_108003594 1.359 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr3_-_10208569 1.345 ENSMUST00000029041.4
 Fabp4
fatty acid binding protein 4, adipocyte
chr1_+_107511416 1.281 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr10_+_96136603 1.271 ENSMUST00000074615.6
 Gm5426
predicted pseudogene 5426

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 11.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.6 7.9 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 4.3 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.7 2.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 2.4 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 2.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.4 2.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.4 1.8 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 1.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 1.5 GO:0006270 DNA replication initiation(GO:0006270)
0.5 1.4 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.3 1.4 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 1.4 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.4 1.3 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 1.3 GO:0071285 cellular response to lithium ion(GO:0071285)
0.1 1.2 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.3 1.1 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.3 1.1 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 1.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 1.0 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 2.8 GO:0030426 growth cone(GO:0030426)
0.3 2.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 1.5 GO:0098644 complex of collagen trimers(GO:0098644)
0.1 1.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)
0.1 0.9 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.9 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.7 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.7 GO:0043196 varicosity(GO:0043196)
0.0 0.7 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 0.5 GO:0000799 nuclear condensin complex(GO:0000799)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.9 7.9 GO:0070324 thyroid hormone binding(GO:0070324)
0.6 3.5 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 2.8 GO:0005518 collagen binding(GO:0005518)
0.1 2.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 2.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.6 1.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 1.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 1.4 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 1.3 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 1.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.4 1.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 1.1 GO:0051525 NFAT protein binding(GO:0051525)
0.3 1.0 GO:0004335 galactokinase activity(GO:0004335)
0.2 1.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 1.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.6 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.4 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.6 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 0.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 2.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 2.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 2.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 1.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.4 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.1 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.1 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 1.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.2 0.8 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.8 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 0.7 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.7 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.7 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling