Motif ID: Pbx2

Z-value: 0.777


Transcription factors associated with Pbx2:

Gene SymbolEntrez IDGene Name
Pbx2 ENSMUSG00000034673.8 Pbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx2mm10_v2_chr17_+_34592248_34592329-0.791.1e-04Click!


Activity profile for motif Pbx2.

activity profile for motif Pbx2


Sorted Z-values histogram for motif Pbx2

Sorted Z-values for motif Pbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 128 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66812593 3.659 ENSMUST00000100572.3
 Sla
src-like adaptor
chr2_+_65620829 2.427 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr5_+_106609098 2.413 ENSMUST00000167618.1
 Gm17304
predicted gene, 17304
chr15_+_21111452 2.176 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr6_+_8259288 2.027 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr2_-_104257400 1.845 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr3_+_121953213 1.702 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr1_-_56972437 1.607 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr6_+_8259327 1.606 ENSMUST00000159378.1
 Gm16039
predicted gene 16039
chrX_+_140367494 1.487 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chr3_-_152982240 1.449 ENSMUST00000044278.5
 St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr11_+_3330401 1.331 ENSMUST00000045153.4
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr11_+_3330781 1.315 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr6_+_8259379 1.310 ENSMUST00000162034.1
ENSMUST00000160705.1
ENSMUST00000159433.1
 Gm16039


predicted gene 16039


chr15_+_92597104 1.227 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr9_+_112234257 0.985 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr8_+_72646679 0.981 ENSMUST00000161386.1
ENSMUST00000093427.4
 Nwd1

NACHT and WD repeat domain containing 1

chr2_+_128967383 0.973 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr8_+_72646728 0.870 ENSMUST00000161254.1
 Nwd1
NACHT and WD repeat domain containing 1
chrX_-_70365052 0.863 ENSMUST00000101509.2
 Ids
iduronate 2-sulfatase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.4 2.6 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 2.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 1.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 1.4 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.8 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.8 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.1 0.7 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 0.6 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.6 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.6 GO:0001553 luteinization(GO:0001553)
0.0 0.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.6 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.5 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 0.5 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.5 GO:0051926 dopamine receptor signaling pathway(GO:0007212) negative regulation of calcium ion transport(GO:0051926)
0.1 0.4 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 0.4 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.4 GO:0000185 activation of MAPKKK activity(GO:0000185)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.9 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.6 GO:0043204 perikaryon(GO:0043204)
0.0 0.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.9 2.6 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 1.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 0.9 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 0.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.7 GO:0051787 misfolded protein binding(GO:0051787)
0.1 0.6 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.6 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.4 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 0.2 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.2 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 0.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) phosphatidylcholine-translocating ATPase activity(GO:0090554)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 2.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.0 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.5 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.8 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.6 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.5 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.1 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway