Motif ID: Zbtb12

Z-value: 0.531


Transcription factors associated with Zbtb12:

Gene SymbolEntrez IDGene Name
Zbtb12 ENSMUSG00000049823.8 Zbtb12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb12mm10_v2_chr17_+_34894515_34894573-0.068.2e-01Click!


Activity profile for motif Zbtb12.

activity profile for motif Zbtb12


Sorted Z-values histogram for motif Zbtb12

Sorted Z-values for motif Zbtb12



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb12

PNG image of the network

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Top targets:


Showing 1 to 20 of 65 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12027958 1.400 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr17_-_15375969 0.969 ENSMUST00000014917.7
 Dll1
delta-like 1 (Drosophila)
chr6_-_124814288 0.862 ENSMUST00000172132.2
 Tpi1
triosephosphate isomerase 1
chr11_+_54902917 0.780 ENSMUST00000149324.1
 Gpx3
glutathione peroxidase 3
chr3_+_88081997 0.751 ENSMUST00000071812.5
 Iqgap3
IQ motif containing GTPase activating protein 3
chr11_+_54902743 0.678 ENSMUST00000082430.3
 Gpx3
glutathione peroxidase 3
chr2_+_31759993 0.610 ENSMUST00000124089.1
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr19_+_59260878 0.596 ENSMUST00000026084.3
 Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
chr3_-_130061553 0.577 ENSMUST00000168675.1
 Sec24b
Sec24 related gene family, member B (S. cerevisiae)
chr8_-_45382198 0.526 ENSMUST00000093526.6
 Fam149a
family with sequence similarity 149, member A
chr6_+_136518820 0.525 ENSMUST00000032335.6
 Atf7ip
activating transcription factor 7 interacting protein
chr11_-_88718078 0.513 ENSMUST00000092794.5
 Msi2
musashi RNA-binding protein 2
chr14_-_103844173 0.513 ENSMUST00000022718.3
 Ednrb
endothelin receptor type B
chr7_-_141918481 0.486 ENSMUST00000151890.1
 Tollip
toll interacting protein
chr4_-_151057933 0.468 ENSMUST00000030797.3
 Vamp3
vesicle-associated membrane protein 3
chr17_-_27029009 0.466 ENSMUST00000078691.5
 Bak1
BCL2-antagonist/killer 1
chr3_-_84155762 0.448 ENSMUST00000047368.6
 Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr7_-_25477607 0.400 ENSMUST00000098669.1
ENSMUST00000098668.1
ENSMUST00000098666.2
 Ceacam1


carcinoembryonic antigen-related cell adhesion molecule 1


chr2_+_31759932 0.381 ENSMUST00000028190.6
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr4_+_32983417 0.380 ENSMUST00000084747.5
 Rragd
Ras-related GTP binding D

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.2 1.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.3 1.0 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.3 1.0 GO:0001757 somite specification(GO:0001757) arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
0.3 0.9 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.8 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.1 0.6 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 0.6 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.2 0.5 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.2 0.5 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 0.5 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.5 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.5 GO:0036010 protein localization to endosome(GO:0036010)
0.1 0.4 GO:2001187 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0 0.4 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.0 0.4 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.4 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.3 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 0.3 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.3 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0031045 dense core granule(GO:0031045)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.5 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 0.4 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0044447 axoneme part(GO:0044447)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0008430 selenium binding(GO:0008430)
0.0 1.5 GO:0005158 insulin receptor binding(GO:0005158)
0.1 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.0 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.9 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.2 0.8 GO:0032027 myosin light chain binding(GO:0032027)
0.2 0.6 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.2 0.5 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.5 GO:0051400 BH domain binding(GO:0051400)
0.0 0.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.4 GO:2001069 glycogen binding(GO:2001069)
0.1 0.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.0 GO:0070736 protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.5 PID_IL1_PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.0 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.6 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.5 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.5 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.3 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism