Motif ID: Zbtb12

Z-value: 0.531


Transcription factors associated with Zbtb12:

Gene SymbolEntrez IDGene Name
Zbtb12 ENSMUSG00000049823.8 Zbtb12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb12mm10_v2_chr17_+_34894515_34894573-0.068.2e-01Click!


Activity profile for motif Zbtb12.

activity profile for motif Zbtb12


Sorted Z-values histogram for motif Zbtb12

Sorted Z-values for motif Zbtb12



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb12

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_12027958 1.400 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr17_-_15375969 0.969 ENSMUST00000014917.7
 Dll1
delta-like 1 (Drosophila)
chr6_-_124814288 0.862 ENSMUST00000172132.2
 Tpi1
triosephosphate isomerase 1
chr11_+_54902917 0.780 ENSMUST00000149324.1
 Gpx3
glutathione peroxidase 3
chr3_+_88081997 0.751 ENSMUST00000071812.5
 Iqgap3
IQ motif containing GTPase activating protein 3
chr11_+_54902743 0.678 ENSMUST00000082430.3
 Gpx3
glutathione peroxidase 3
chr2_+_31759993 0.610 ENSMUST00000124089.1
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr19_+_59260878 0.596 ENSMUST00000026084.3
 Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
chr3_-_130061553 0.577 ENSMUST00000168675.1
 Sec24b
Sec24 related gene family, member B (S. cerevisiae)
chr8_-_45382198 0.526 ENSMUST00000093526.6
 Fam149a
family with sequence similarity 149, member A
chr6_+_136518820 0.525 ENSMUST00000032335.6
 Atf7ip
activating transcription factor 7 interacting protein
chr11_-_88718078 0.513 ENSMUST00000092794.5
 Msi2
musashi RNA-binding protein 2
chr14_-_103844173 0.513 ENSMUST00000022718.3
 Ednrb
endothelin receptor type B
chr7_-_141918481 0.486 ENSMUST00000151890.1
 Tollip
toll interacting protein
chr4_-_151057933 0.468 ENSMUST00000030797.3
 Vamp3
vesicle-associated membrane protein 3
chr17_-_27029009 0.466 ENSMUST00000078691.5
 Bak1
BCL2-antagonist/killer 1
chr3_-_84155762 0.448 ENSMUST00000047368.6
 Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr7_-_25477607 0.400 ENSMUST00000098669.1
ENSMUST00000098668.1
ENSMUST00000098666.2
 Ceacam1


carcinoembryonic antigen-related cell adhesion molecule 1


chr2_+_31759932 0.381 ENSMUST00000028190.6
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr4_+_32983417 0.380 ENSMUST00000084747.5
 Rragd
Ras-related GTP binding D
chr5_+_92603039 0.376 ENSMUST00000050952.3
 Stbd1
starch binding domain 1
chr7_+_92875253 0.345 ENSMUST00000076052.6
 Prcp
prolylcarboxypeptidase (angiotensinase C)
chr6_+_108065035 0.316 ENSMUST00000049246.6
 Setmar
SET domain without mariner transposase fusion
chr17_+_27909337 0.269 ENSMUST00000114842.1
ENSMUST00000025058.7
ENSMUST00000088027.5
 Anks1


ankyrin repeat and SAM domain containing 1


chr9_+_22411515 0.267 ENSMUST00000058868.7
 9530077C05Rik
RIKEN cDNA 9530077C05 gene
chr1_+_69826986 0.266 ENSMUST00000065425.5
ENSMUST00000113940.2
 Spag16

sperm associated antigen 16

chr4_-_119173849 0.243 ENSMUST00000052715.4
ENSMUST00000179290.1
ENSMUST00000154226.1
 Zfp691


zinc finger protein 691


chr15_+_82341179 0.243 ENSMUST00000050349.2
 Fam109b
family with sequence similarity 109, member B
chr2_-_28916668 0.240 ENSMUST00000113847.1
 Barhl1
BarH-like 1 (Drosophila)
chr16_-_33967032 0.224 ENSMUST00000023510.6
 Umps
uridine monophosphate synthetase
chr9_+_57827284 0.204 ENSMUST00000163186.1
 Gm17231
predicted gene 17231
chr4_-_149909719 0.203 ENSMUST00000105685.1
 Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
chr19_-_10240689 0.185 ENSMUST00000088013.5
 Myrf
myelin regulatory factor
chr4_+_119539716 0.179 ENSMUST00000137560.1
 Foxj3
forkhead box J3
chr13_+_104229366 0.177 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr14_+_79481164 0.170 ENSMUST00000040131.5
 Elf1
E74-like factor 1
chr17_+_17831004 0.164 ENSMUST00000172097.2
 4930546H06Rik
RIKEN cDNA 4930546H06 gene
chr15_-_79546741 0.153 ENSMUST00000054014.7
 Ddx17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr5_+_67260696 0.146 ENSMUST00000161233.1
ENSMUST00000160352.1
 Tmem33

transmembrane protein 33

chr18_-_70472429 0.138 ENSMUST00000067556.3
 4930503L19Rik
RIKEN cDNA 4930503L19 gene
chr8_-_69774884 0.137 ENSMUST00000137573.1
ENSMUST00000149782.1
 Zfp866
Gm20422
zinc finger protein 866
predicted gene 20422
chr5_+_122850186 0.121 ENSMUST00000031434.6
 Rnf34
ring finger protein 34
chr3_+_5218589 0.117 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr7_+_126976338 0.110 ENSMUST00000032920.3
 Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr17_-_27909206 0.106 ENSMUST00000114848.1
 Taf11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr6_+_37900477 0.101 ENSMUST00000120238.1
 Trim24
tripartite motif-containing 24
chr19_-_40402267 0.095 ENSMUST00000099467.3
ENSMUST00000099466.3
ENSMUST00000165212.1
ENSMUST00000165469.1
 Sorbs1



sorbin and SH3 domain containing 1



chr6_+_29398920 0.092 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr2_+_30364262 0.089 ENSMUST00000142801.1
ENSMUST00000100214.3
 Fam73b

family with sequence similarity 73, member B

chr12_-_101958148 0.086 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
 Atxn3



ataxin 3



chr13_+_76098734 0.078 ENSMUST00000091466.3
 Ttc37
tetratricopeptide repeat domain 37
chrX_+_94724569 0.072 ENSMUST00000101388.2
 Zxdb
zinc finger, X-linked, duplicated B
chr11_-_100441795 0.064 ENSMUST00000107398.1
 Nt5c3b
5'-nucleotidase, cytosolic IIIB
chr12_+_105784694 0.064 ENSMUST00000109901.2
ENSMUST00000168186.1
ENSMUST00000163473.1
ENSMUST00000170540.1
ENSMUST00000166735.1
ENSMUST00000170002.1
 Papola





poly (A) polymerase alpha





chr3_+_5218516 0.062 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr2_+_30364227 0.046 ENSMUST00000077977.7
ENSMUST00000140075.2
 Fam73b

family with sequence similarity 73, member B

chr7_-_127993831 0.036 ENSMUST00000033056.3
 Pycard
PYD and CARD domain containing
chr15_-_88954400 0.034 ENSMUST00000109371.1
 Ttll8
tubulin tyrosine ligase-like family, member 8
chr4_-_133633419 0.033 ENSMUST00000084238.4
 Zdhhc18
zinc finger, DHHC domain containing 18
chr11_+_49247462 0.033 ENSMUST00000109194.1
 Mgat1
mannoside acetylglucosaminyltransferase 1
chr3_-_131344892 0.032 ENSMUST00000090246.4
ENSMUST00000126569.1
 Sgms2

sphingomyelin synthase 2

chr5_+_95956916 0.020 ENSMUST00000023840.5
 Cxcl13
chemokine (C-X-C motif) ligand 13
chr17_-_56874421 0.020 ENSMUST00000043062.4
 Acsbg2
acyl-CoA synthetase bubblegum family member 2
chr11_+_98446826 0.012 ENSMUST00000019456.4
 Grb7
growth factor receptor bound protein 7
chr6_+_90462562 0.012 ENSMUST00000032174.5
 Klf15
Kruppel-like factor 15

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.3 1.0 GO:0001757 somite specification(GO:0001757) arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
0.3 0.9 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 0.5 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.2 1.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 0.5 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.1 0.6 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 0.4 GO:2001187 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.6 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 0.3 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 0.8 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.1 0.2 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1 1.5 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.3 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.0 0.4 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.0 0.3 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0 0.5 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:0072592 oxygen metabolic process(GO:0072592) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.5 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.5 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.2 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.4 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.2 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.0 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.0 0.4 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.1 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.0 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.0 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.3 GO:0044447 axoneme part(GO:0044447)
0.0 0.5 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.2 0.5 GO:0004962 endothelin receptor activity(GO:0004962)
0.2 0.8 GO:0032027 myosin light chain binding(GO:0032027)
0.1 1.5 GO:0008430 selenium binding(GO:0008430)
0.1 0.4 GO:2001069 glycogen binding(GO:2001069)
0.1 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.9 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.0 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 1.5 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.5 GO:0051400 BH domain binding(GO:0051400)
0.0 0.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.0 GO:0070736 protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.4 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.5 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.8 PID_RAC1_PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 1.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 0.6 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.5 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.2 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.5 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis