Motif ID: Otx1

Z-value: 0.639


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_220016310.727.0e-04Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 90 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_38271310 2.295 ENSMUST00000032585.6
 Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr9_+_108479849 1.900 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr5_-_98566762 1.900 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr11_+_94936224 1.316 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr16_-_59632520 1.307 ENSMUST00000118438.1
 Arl6
ADP-ribosylation factor-like 6
chrX_-_48513518 1.295 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr17_+_35861318 1.180 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr10_-_88605017 1.174 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr10_+_3973086 1.113 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr2_-_151980135 1.111 ENSMUST00000062047.5
 Fam110a
family with sequence similarity 110, member A
chr3_+_54481429 1.090 ENSMUST00000091130.3
 Gm5641
predicted gene 5641
chr11_+_78346666 1.043 ENSMUST00000100755.3
 Unc119
unc-119 homolog (C. elegans)
chr13_-_21750505 1.025 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr5_-_5749317 0.877 ENSMUST00000015796.2
 Steap1
six transmembrane epithelial antigen of the prostate 1
chr1_-_165708088 0.870 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr18_+_86711520 0.841 ENSMUST00000122464.1
 Cbln2
cerebellin 2 precursor protein
chr5_-_37336870 0.824 ENSMUST00000031005.4
 Evc
Ellis van Creveld gene syndrome
chr13_+_21735055 0.783 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr13_+_41016250 0.775 ENSMUST00000021790.5
 Tmem14c
transmembrane protein 14C
chr7_-_132154717 0.768 ENSMUST00000033149.4
 Cpxm2
carboxypeptidase X 2 (M14 family)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.4 1.9 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 1.8 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 1.4 GO:0003416 endochondral bone growth(GO:0003416)
0.3 1.3 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.2 1.3 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 1.3 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.2 1.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 1.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 1.1 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.2 1.0 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.2 0.9 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.9 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.8 GO:0006783 heme biosynthetic process(GO:0006783)
0.2 0.7 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.2 0.7 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 0.7 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.6 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.3 1.9 GO:0043256 laminin complex(GO:0043256)
0.1 1.8 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 1.3 GO:0005584 collagen type I trimer(GO:0005584)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 1.2 GO:0005859 muscle myosin complex(GO:0005859)
0.0 1.0 GO:0051233 spindle midzone(GO:0051233)
0.1 0.8 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 0.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.7 GO:0002177 manchette(GO:0002177)
0.0 0.7 GO:0030904 retromer complex(GO:0030904)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.3 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.2 GO:0031983 vesicle lumen(GO:0031983)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0042393 histone binding(GO:0042393)
0.8 2.3 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 1.9 GO:0005178 integrin binding(GO:0005178)
0.4 1.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 1.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 1.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.3 1.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.3 0.9 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 0.8 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.7 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.2 0.6 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.6 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.5 GO:0008430 selenium binding(GO:0008430)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.3 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.3 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.4 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.8 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.3 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.6 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)