Motif ID: Hoxd8

Z-value: 0.636


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

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Top targets:


Showing 1 to 20 of 80 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_138848576 2.262 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr17_-_48432723 2.051 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr3_+_94372794 1.804 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr11_+_117809687 1.509 ENSMUST00000120928.1
ENSMUST00000175737.1
 Syngr2

synaptogyrin 2

chr10_+_97482350 1.420 ENSMUST00000163448.2
 Dcn
decorin
chr11_+_117809653 1.370 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
 Syngr2

Gm20708
synaptogyrin 2

predicted gene 20708
chr18_+_11633276 1.302 ENSMUST00000115861.2
 Rbbp8
retinoblastoma binding protein 8
chr12_-_87444017 1.207 ENSMUST00000091090.4
 2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr19_+_24875679 1.052 ENSMUST00000073080.5
 Gm10053
predicted gene 10053
chr3_+_127633134 1.026 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chrX_+_56786527 0.984 ENSMUST00000144600.1
 Fhl1
four and a half LIM domains 1
chr2_+_83724397 0.911 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
 Itgav


integrin alpha V


chr3_+_24333046 0.749 ENSMUST00000077389.6
 Gm7536
predicted gene 7536
chr10_-_127030813 0.747 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr12_-_84617326 0.738 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr5_+_92809372 0.717 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr1_-_172027269 0.709 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr6_+_71282280 0.707 ENSMUST00000080949.7
 Krcc1
lysine-rich coiled-coil 1
chr8_-_106573461 0.704 ENSMUST00000073722.5
 Gm10073
predicted pseudogene 10073
chr6_+_34384218 0.674 ENSMUST00000038383.7
ENSMUST00000115051.1
 Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.7 2.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 1.8 GO:0072615 interleukin-17 secretion(GO:0072615)
0.2 1.4 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.3 1.3 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.3 1.2 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 1.0 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.2 0.7 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.7 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.6 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0 0.6 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.5 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 0.4 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 0.4 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.4 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.3 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.3 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.3 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.3 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.4 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 0.9 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.2 0.7 GO:0060187 cell pole(GO:0060187)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.5 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0032156 septin cytoskeleton(GO:0032156)
0.1 0.2 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.1 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.5 1.8 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.0 GO:0070888 E-box binding(GO:0070888)
0.2 0.9 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.1 0.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.4 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 0.3 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.3 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.3 PID_BARD1_PATHWAY BARD1 signaling events
0.1 0.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.6 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.3 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.9 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.6 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 0.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.3 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.3 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.1 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.1 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex