Motif ID: Epas1_Bcl3

Z-value: 2.152

Transcription factors associated with Epas1_Bcl3:

Gene SymbolEntrez IDGene Name
Bcl3 ENSMUSG00000053175.10 Bcl3
Epas1 ENSMUSG00000024140.9 Epas1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Epas1mm10_v2_chr17_+_86753900_867539140.691.7e-03Click!


Activity profile for motif Epas1_Bcl3.

activity profile for motif Epas1_Bcl3


Sorted Z-values histogram for motif Epas1_Bcl3

Sorted Z-values for motif Epas1_Bcl3



Network of associatons between targets according to the STRING database.



First level regulatory network of Epas1_Bcl3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_48045144 11.046 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr10_+_127725392 10.850 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr8_-_48555846 10.629 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr3_-_80802789 9.863 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr14_-_60177482 9.727 ENSMUST00000140924.1
 Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr9_-_40346290 7.983 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr12_-_14152038 7.779 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chr2_+_4300462 7.327 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr12_-_67221221 6.301 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr2_-_113217051 6.273 ENSMUST00000080673.5
 Ryr3
ryanodine receptor 3
chr17_+_86167777 6.145 ENSMUST00000097275.2
 Prkce
protein kinase C, epsilon
chr9_-_29963112 5.995 ENSMUST00000075069.4
 Ntm
neurotrimin
chr4_-_20778527 5.981 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3
chr17_+_48932368 5.815 ENSMUST00000046254.2
 Lrfn2
leucine rich repeat and fibronectin type III domain containing 2
chr19_+_8664005 5.374 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr7_-_27446599 5.313 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4
chr16_-_38713235 5.063 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr1_+_75507077 4.919 ENSMUST00000037330.4
 Inha
inhibin alpha
chr3_-_127225847 4.856 ENSMUST00000182726.1
ENSMUST00000182779.1
 Ank2

ankyrin 2, brain

chr15_+_81936911 4.730 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.2 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
1.6 12.6 GO:0097264 self proteolysis(GO:0097264)
3.7 11.0 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
2.7 10.8 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 9.6 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
0.1 8.5 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.3 8.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.4 8.2 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.2 8.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.8 7.5 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
1.2 7.4 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.8 7.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.5 6.9 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
1.5 6.1 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.2 5.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.9 5.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 4.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 4.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 4.5 GO:0035988 chondrocyte proliferation(GO:0035988)
0.9 4.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.6 GO:0045202 synapse(GO:0045202)
0.7 15.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 8.7 GO:0000139 Golgi membrane(GO:0000139)
2.7 8.2 GO:0043512 inhibin A complex(GO:0043512)
0.5 7.4 GO:0031143 pseudopodium(GO:0031143)
0.3 7.1 GO:0031430 M band(GO:0031430)
0.1 7.1 GO:0005923 bicellular tight junction(GO:0005923)
0.0 6.7 GO:0097458 neuron part(GO:0097458)
0.0 6.4 GO:0030027 lamellipodium(GO:0030027)
1.3 6.3 GO:0030314 junctional membrane complex(GO:0030314)
0.0 6.1 GO:0005768 endosome(GO:0005768)
0.0 5.7 GO:0043204 perikaryon(GO:0043204)
0.1 5.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.9 5.3 GO:0008091 spectrin(GO:0008091)
0.0 5.1 GO:0005802 trans-Golgi network(GO:0005802)
0.5 4.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.9 4.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 4.6 GO:0043197 dendritic spine(GO:0043197)
1.1 4.5 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 4.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.7 GO:0030507 spectrin binding(GO:0030507)
0.5 13.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 11.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
1.8 10.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 9.0 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.9 8.2 GO:0034711 inhibin binding(GO:0034711)
2.5 7.4 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 7.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2 6.7 GO:0043015 gamma-tubulin binding(GO:0043015)
2.1 6.3 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
1.5 6.1 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 5.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 5.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 5.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 5.1 GO:0017124 SH3 domain binding(GO:0017124)
0.6 4.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.8 4.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 4.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 4.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 4.4 GO:0048365 Rac GTPase binding(GO:0048365)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 16.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.4 11.0 ST_GA12_PATHWAY G alpha 12 Pathway
0.2 10.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 8.5 PID_LKB1_PATHWAY LKB1 signaling events
0.2 7.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.8 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 3.6 PID_ALK1_PATHWAY ALK1 signaling events
0.0 3.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.0 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.1 2.7 PID_SHP2_PATHWAY SHP2 signaling
0.1 2.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 1.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.7 PID_CONE_PATHWAY Visual signal transduction: Cones
0.1 1.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 1.5 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.2 PID_P73PATHWAY p73 transcription factor network
0.0 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.5 11.1 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
2.0 8.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.6 8.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 8.1 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 8.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 7.7 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 6.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 5.1 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 4.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 4.5 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 4.4 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.3 4.3 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 4.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 4.0 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 3.9 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.2 3.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 3.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.1 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type