Motif ID: Sin3a

Z-value: 1.418


Transcription factors associated with Sin3a:

Gene SymbolEntrez IDGene Name
Sin3a ENSMUSG00000042557.8 Sin3a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sin3amm10_v2_chr9_+_57072024_570720480.474.9e-02Click!


Activity profile for motif Sin3a.

activity profile for motif Sin3a


Sorted Z-values histogram for motif Sin3a

Sorted Z-values for motif Sin3a



Network of associatons between targets according to the STRING database.



First level regulatory network of Sin3a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_69360294 6.105 ENSMUST00000033532.6
 Aff2
AF4/FMR2 family, member 2
chr16_-_67620880 4.981 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr15_-_66286224 4.492 ENSMUST00000070256.7
 Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chr1_-_56971762 4.453 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr9_-_98033181 4.340 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chrX_-_104201126 4.236 ENSMUST00000056502.6
ENSMUST00000118314.1
 C77370

expressed sequence C77370

chrX_-_104201099 3.974 ENSMUST00000087879.4
 C77370
expressed sequence C77370
chr16_+_91269759 3.946 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr9_-_98032983 3.858 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr18_-_58209926 3.765 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr16_-_67620805 3.721 ENSMUST00000120594.1
 Cadm2
cell adhesion molecule 2
chr1_-_56972437 3.613 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr6_+_141524379 3.612 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr16_+_91225550 3.593 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr4_+_107802277 3.573 ENSMUST00000106733.2
ENSMUST00000030356.3
ENSMUST00000106732.2
ENSMUST00000126573.1
 Lrp8



low density lipoprotein receptor-related protein 8, apolipoprotein e receptor



chr18_+_34861200 3.384 ENSMUST00000165033.1
 Egr1
early growth response 1
chr9_-_40455670 3.327 ENSMUST00000165104.1
ENSMUST00000045682.5
 Gramd1b

GRAM domain containing 1B

chr1_-_119837613 3.237 ENSMUST00000064091.5
 Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr5_+_88886809 3.110 ENSMUST00000148750.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr15_-_78120011 2.981 ENSMUST00000019290.2
 Cacng2
calcium channel, voltage-dependent, gamma subunit 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 488 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.0 11.7 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.5 7.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.2 6.1 GO:0035063 nuclear speck organization(GO:0035063)
0.4 5.7 GO:0060081 membrane hyperpolarization(GO:0060081)
0.2 5.5 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.6 5.1 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.8 4.6 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.6 4.3 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0 4.3 GO:0006813 potassium ion transport(GO:0006813)
0.5 4.2 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.5 4.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.3 4.0 GO:1990403 embryonic brain development(GO:1990403)
1.3 3.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.8 3.8 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
1.2 3.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 3.5 GO:2000463 positive regulation of excitatory postsynaptic potential(GO:2000463)
1.1 3.4 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.3 3.4 GO:0042118 endothelial cell activation(GO:0042118)
0.4 3.3 GO:0071420 cellular response to histamine(GO:0071420)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 15.3 GO:0032809 neuronal cell body membrane(GO:0032809)
2.0 11.7 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.4 11.2 GO:0043194 axon initial segment(GO:0043194)
0.1 8.2 GO:0005814 centriole(GO:0005814)
0.2 8.1 GO:0048786 presynaptic active zone(GO:0048786)
0.1 8.0 GO:0005901 caveola(GO:0005901)
0.0 7.7 GO:0000139 Golgi membrane(GO:0000139)
0.1 5.4 GO:0030118 clathrin coat(GO:0030118)
0.0 5.0 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 4.9 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.9 4.7 GO:0030314 junctional membrane complex(GO:0030314)
0.2 4.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 4.6 GO:0031225 anchored component of membrane(GO:0031225)
0.3 4.5 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 4.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.3 3.9 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.6 3.3 GO:0042025 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.6 3.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.3 3.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 289 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.2 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.8 8.6 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 8.4 GO:0008017 microtubule binding(GO:0008017)
1.0 7.3 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.2 6.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 5.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 5.4 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
1.3 5.1 GO:0038025 reelin receptor activity(GO:0038025)
1.0 5.0 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 4.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 4.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.6 4.4 GO:0046790 virion binding(GO:0046790)
0.7 4.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.5 4.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 4.2 GO:0030507 spectrin binding(GO:0030507)
0.1 4.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 3.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.9 3.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 3.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 3.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 6.0 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 5.8 PID_BCR_5PATHWAY BCR signaling pathway
0.3 5.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 5.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 3.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 3.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.5 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 3.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 3.0 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.6 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.1 2.5 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 2.1 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 1.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.3 1.8 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.1 1.8 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 1.7 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 1.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 1.4 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 1.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 7.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.4 6.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 5.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 5.2 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 5.2 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.3 5.0 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 4.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 4.2 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 4.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 4.1 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.3 3.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 3.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 3.5 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 3.5 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.3 3.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 3.3 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 3.1 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 2.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 2.7 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions