Motif ID: Hoxa3

Z-value: 0.707


Transcription factors associated with Hoxa3:

Gene SymbolEntrez IDGene Name
Hoxa3 ENSMUSG00000079560.7 Hoxa3



Activity profile for motif Hoxa3.

activity profile for motif Hoxa3


Sorted Z-values histogram for motif Hoxa3

Sorted Z-values for motif Hoxa3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa3

PNG image of the network

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Top targets:


Showing 1 to 20 of 35 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70853482 4.039 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr2_-_168767136 3.326 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr3_+_55782500 2.899 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr2_-_168767029 2.650 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr9_+_119063429 2.542 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr10_-_37138863 1.911 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr3_+_159839729 1.382 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr13_-_102905740 1.341 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102906046 1.340 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr10_+_37139558 1.289 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr2_+_109917639 1.052 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr17_+_17402672 0.803 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr12_+_59013379 0.748 ENSMUST00000021379.7
 Gemin2
gem (nuclear organelle) associated protein 2
chr10_+_26772477 0.690 ENSMUST00000039557.7
 Arhgap18
Rho GTPase activating protein 18
chr1_-_172027269 0.666 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr5_+_138187485 0.661 ENSMUST00000110934.2
 Cnpy4
canopy 4 homolog (zebrafish)
chr3_-_86548268 0.588 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr5_-_138187177 0.585 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
 Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr7_-_38019505 0.572 ENSMUST00000085513.4
 Uri1
URI1, prefoldin-like chaperone
chr14_+_79515618 0.512 ENSMUST00000110835.1
 Elf1
E74-like factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.3 4.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 2.5 GO:0051693 actin filament capping(GO:0051693)
0.1 1.9 GO:0051764 actin crosslink formation(GO:0051764)
0.5 1.4 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.4 1.1 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.3 0.8 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.8 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.6 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.3 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0000792 heterochromatin(GO:0000792)
0.6 1.9 GO:0042585 germinal vesicle(GO:0042585)
0.0 1.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 0.8 GO:0060187 cell pole(GO:0060187)
0.1 0.7 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.6 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.0 GO:0070410 co-SMAD binding(GO:0070410)
0.0 2.9 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 2.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.5 GO:0051015 actin filament binding(GO:0051015)
0.0 1.9 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.4 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 1.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.3 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 0.3 GO:0019770 IgG receptor activity(GO:0019770)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 4.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 1.9 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.7 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 0.6 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.5 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta