ISMARA results: Rorc

Motif ID: Rorc_Nr1d1

Z-value: 0.639

Transcription factors associated with Rorc_Nr1d1:

Gene Symbol	Entrez ID	Gene Name
Nr1d1	ENSMUSG00000020889.11	Nr1d1
Rorc	ENSMUSG00000028150.8	Rorc

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Rorc	mm10_v2_chr3_+_94372794_94372872	-0.06	8.2e-01	Click!
Nr1d1	mm10_v2_chr11_-_98775333_98775354	0.03	9.1e-01	Click!

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Top targets:

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Showing 1 to 20 of 116 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_+_33638056	0.879	ENSMUST00000052079.7	Pram1	PML-RAR alpha-regulated adaptor molecule 1
chr15_-_65014904	0.852	ENSMUST00000110100.2	Gm21961	predicted gene, 21961
chr7_+_45705088	0.833	ENSMUST00000080885.3	Dbp	D site albumin promoter binding protein
chr17_-_46031813	0.705	ENSMUST00000024747.7	Vegfa	vascular endothelial growth factor A
chr17_-_24886304	0.694	ENSMUST00000044252.5	Nubp2	nucleotide binding protein 2
chr2_+_90885860	0.659	ENSMUST00000111466.2	C1qtnf4	C1q and tumor necrosis factor related protein 4
chr8_-_85080652	0.620	ENSMUST00000152785.1	Wdr83	WD repeat domain containing 83
chr10_+_106470281	0.603	ENSMUST00000029404.9 ENSMUST00000169303.1	Ppfia2	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr8_-_85080679	0.561	ENSMUST00000093357.5	Wdr83	WD repeat domain containing 83
chr15_+_62037986	0.543	ENSMUST00000182956.1 ENSMUST00000182075.1 ENSMUST00000180432.2 ENSMUST00000181416.2 ENSMUST00000181657.2	Pvt1	plasmacytoma variant translocation 1
chr17_-_46032366	0.523	ENSMUST00000071648.5 ENSMUST00000142351.2 ENSMUST00000167860.1	Vegfa	vascular endothelial growth factor A
chr12_+_116047713	0.519	ENSMUST00000073551.5 ENSMUST00000183125.1	Zfp386	zinc finger protein 386 (Kruppel-like)
chr11_+_98348404	0.514	ENSMUST00000078694.6	Ppp1r1b	protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr9_-_75441652	0.511	ENSMUST00000181896.1	A130057D12Rik	RIKEN cDNA A130057D12 gene
chr5_-_123141067	0.503	ENSMUST00000162697.1 ENSMUST00000160321.1 ENSMUST00000159637.1	AI480526	expressed sequence AI480526
chr12_-_34528844	0.484	ENSMUST00000110819.2	Hdac9	histone deacetylase 9
chr5_+_64970069	0.482	ENSMUST00000031080.8	Fam114a1	family with sequence similarity 114, member A1
chr4_-_55532453	0.450	ENSMUST00000132746.1 ENSMUST00000107619.2	Klf4	Kruppel-like factor 4 (gut)
chr11_+_88718442	0.431	ENSMUST00000138007.1	C030037D09Rik	RIKEN cDNA C030037D09 gene
chr17_+_45686322	0.420	ENSMUST00000024734.7	Mrpl14	mitochondrial ribosomal protein L14

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 30 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.2	GO:1902336	neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.1	1.2	GO:1902563	regulation of neutrophil activation(GO:1902563)
0.1	0.8	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.6	GO:0016226	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2	0.5	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.2	0.5	GO:0014738	regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.1	0.5	GO:2000158	positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1	0.4	GO:0038163	thrombopoietin-mediated signaling pathway(GO:0038163)
0.1	0.4	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.4	GO:0050901	leukocyte tethering or rolling(GO:0050901)
0.1	0.3	GO:0090403	oxidative stress-induced premature senescence(GO:0090403)
0.0	0.3	GO:0060134	prepulse inhibition(GO:0060134)
0.2	0.2	GO:0007113	endomitotic cell cycle(GO:0007113)
0.1	0.2	GO:1902162	regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162)
0.1	0.2	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.1	0.2	GO:2000508	regulation of dendritic cell chemotaxis(GO:2000508)
0.0	0.2	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.0	0.2	GO:0032811	negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.0	0.2	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.2	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)

Gene overrepresentation in cellular_component category:

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Showing 1 to 9 of 9 entries

Total log-likelihood	Term	Description
1.2	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.7	GO:0031616	spindle pole centrosome(GO:0031616)
0.5	GO:0005719	nuclear euchromatin(GO:0005719)
0.3	GO:0033391	chromatoid body(GO:0033391)
0.2	GO:0038039	G-protein coupled receptor heterodimeric complex(GO:0038039)
0.2	GO:0097227	sperm annulus(GO:0097227)
0.2	GO:0016272	prefoldin complex(GO:0016272)
0.2	GO:0000783	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1	GO:0019815	B cell receptor complex(GO:0019815)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 20 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.4	GO:0005125	cytokine activity(GO:0005125)
0.4	1.2	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0	0.8	GO:0034979	NAD-dependent protein deacetylase activity(GO:0034979)
0.0	0.6	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
0.2	0.5	GO:0031752	D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.1	0.5	GO:0035800	deubiquitinase activator activity(GO:0035800)
0.1	0.5	GO:0001010	transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0	0.3	GO:0019841	retinol binding(GO:0019841)
0.0	0.3	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.1	0.2	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.2	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.2	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.2	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.2	GO:0031811	G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0	0.2	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.2	GO:0017022	myosin binding(GO:0017022)
0.0	0.1	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.1	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0015234	thiamine transmembrane transporter activity(GO:0015234)

Gene overrepresentation in C2:CP category:

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Showing 1 to 3 of 3 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	PID_VEGF_VEGFR_PATHWAY	VEGF and VEGFR signaling network
0.0	0.3	PID_CIRCADIAN_PATHWAY	Circadian rhythm pathway
0.0	0.2	PID_ERB_GENOMIC_PATHWAY	Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 7 of 7 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	1.2	REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.5	REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.5	REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	0.5	REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION	Genes involved in Platelet Aggregation (Plug Formation)
0.0	0.2	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0	0.2	REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)