Motif ID: Nrf1

Z-value: 2.244


Transcription factors associated with Nrf1:

Gene SymbolEntrez IDGene Name
Nrf1 ENSMUSG00000058440.8 Nrf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nrf1mm10_v2_chr6_+_30047979_300480490.155.5e-01Click!


Activity profile for motif Nrf1.

activity profile for motif Nrf1


Sorted Z-values histogram for motif Nrf1

Sorted Z-values for motif Nrf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nrf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_79682304 5.710 ENSMUST00000166603.1
 Cdc34
cell division cycle 34
chr11_-_69921329 3.962 ENSMUST00000108613.3
ENSMUST00000043419.3
ENSMUST00000070996.4
 Eif5a


eukaryotic translation initiation factor 5A


chr10_+_79682169 3.804 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr13_-_53286052 3.785 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr11_-_69921190 3.441 ENSMUST00000108607.1
 Eif5a
eukaryotic translation initiation factor 5A
chr11_+_40733936 3.320 ENSMUST00000127382.1
 Nudcd2
NudC domain containing 2
chr19_+_41911851 3.255 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr17_+_48409980 3.216 ENSMUST00000167180.1
ENSMUST00000046651.6
 Oard1

O-acyl-ADP-ribose deacylase 1

chr11_+_40733639 3.208 ENSMUST00000020578.4
 Nudcd2
NudC domain containing 2
chr2_+_168081004 3.048 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr7_-_29281977 2.963 ENSMUST00000098604.4
ENSMUST00000108236.3
 Spint2

serine protease inhibitor, Kunitz type 2

chr8_+_122568001 2.893 ENSMUST00000006760.2
 Cdt1
chromatin licensing and DNA replication factor 1
chr11_+_86544982 2.854 ENSMUST00000108030.2
ENSMUST00000020821.3
ENSMUST00000069503.6
ENSMUST00000167178.2
 Tubd1



tubulin, delta 1



chr14_+_59625281 2.836 ENSMUST00000053949.5
 Shisa2
shisa homolog 2 (Xenopus laevis)
chr11_-_69921057 2.823 ENSMUST00000108609.1
ENSMUST00000108608.1
ENSMUST00000164359.1
 Eif5a


eukaryotic translation initiation factor 5A


chr15_+_88751649 2.811 ENSMUST00000041297.8
 Zbed4
zinc finger, BED domain containing 4
chr16_-_90727329 2.719 ENSMUST00000099554.4
 Mis18a
MIS18 kinetochore protein homolog A (S. pombe)
chr14_-_20181773 2.580 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr10_-_80399389 2.575 ENSMUST00000105348.1
 Mbd3
methyl-CpG binding domain protein 3
chr2_-_157135200 2.473 ENSMUST00000109549.2
ENSMUST00000088523.4
ENSMUST00000057725.3
 Samhd1


SAM domain and HD domain, 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 544 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 12.3 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.3 12.2 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 11.4 GO:0006457 protein folding(GO:0006457)
0.1 9.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
1.2 9.3 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.2 5.9 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.5 5.8 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.1 5.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 5.1 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.2 4.8 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.1 4.8 GO:0006413 translational initiation(GO:0006413)
1.2 4.7 GO:0006203 dGTP catabolic process(GO:0006203) dATP catabolic process(GO:0046061)
0.8 4.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.4 4.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.5 4.5 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.6 4.2 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.5 4.1 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.8 4.0 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.1 3.9 GO:0042168 heme metabolic process(GO:0042168)
0.1 3.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 249 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 13.5 GO:0005642 annulate lamellae(GO:0005642)
0.3 12.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.4 8.4 GO:0045120 pronucleus(GO:0045120)
0.1 8.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 7.7 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 7.0 GO:0005643 nuclear pore(GO:0005643)
0.3 6.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.3 6.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.5 6.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.5 5.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.8 5.3 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 5.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 4.9 GO:0000775 chromosome, centromeric region(GO:0000775)
1.6 4.7 GO:0005673 transcription factor TFIIE complex(GO:0005673)
1.6 4.7 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 4.7 GO:0043296 apical junction complex(GO:0043296)
0.3 4.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 4.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 4.3 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 4.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 338 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 13.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 12.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 10.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 9.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 8.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 7.5 GO:0051082 unfolded protein binding(GO:0051082)
0.5 7.3 GO:0030957 Tat protein binding(GO:0030957)
0.1 6.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 5.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 5.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 4.6 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.4 4.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.3 4.1 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.2 4.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 3.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 3.9 GO:0002039 p53 binding(GO:0002039)
0.1 3.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 3.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.1 3.4 GO:0010698 acetyltransferase activator activity(GO:0010698)
1.1 3.4 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.2 9.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 8.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 5.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.2 PID_PLK1_PATHWAY PLK1 signaling events
0.1 4.1 PID_MYC_PATHWAY C-MYC pathway
0.1 3.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 3.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.2 3.0 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 2.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 2.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.2 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.9 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 1.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.6 PID_ATM_PATHWAY ATM pathway
0.0 1.6 PID_CERAMIDE_PATHWAY Ceramide signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.5 13.7 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 12.7 REACTOME_TRANSLATION Genes involved in Translation
0.1 12.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 10.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 9.0 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 8.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 8.1 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.4 7.4 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.2 7.3 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 7.1 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.3 5.8 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2 5.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.3 5.3 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 5.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 5.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 4.9 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 4.7 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.3 4.7 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.2 4.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta