Motif ID: Nkx6-1_Evx1_Hesx1

Z-value: 0.661

Transcription factors associated with Nkx6-1_Evx1_Hesx1:

Gene SymbolEntrez IDGene Name
Evx1 ENSMUSG00000005503.8 Evx1
Hesx1 ENSMUSG00000040726.8 Hesx1
Nkx6-1 ENSMUSG00000035187.8 Nkx6-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-1mm10_v2_chr5_-_101665195_101665226-0.087.4e-01Click!


Activity profile for motif Nkx6-1_Evx1_Hesx1.

activity profile for motif Nkx6-1_Evx1_Hesx1


Sorted Z-values histogram for motif Nkx6-1_Evx1_Hesx1

Sorted Z-values for motif Nkx6-1_Evx1_Hesx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-1_Evx1_Hesx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_98053415 4.917 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr5_-_62766153 3.646 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_+_23415400 3.593 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chrX_-_143933089 3.209 ENSMUST00000087313.3
 Dcx
doublecortin
chr1_-_155417394 3.087 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr15_+_18818895 2.730 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr16_+_45094036 2.342 ENSMUST00000061050.5
 Ccdc80
coiled-coil domain containing 80
chr16_-_97170707 2.250 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr8_-_34965631 2.198 ENSMUST00000033929.4
 Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr9_-_55919605 2.173 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr13_+_94083490 2.160 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr3_+_62419668 2.119 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr15_-_66812593 2.087 ENSMUST00000100572.3
 Sla
src-like adaptor
chr6_-_101377897 1.997 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr9_+_113812547 1.975 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr1_+_72284367 1.927 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr2_-_5676046 1.870 ENSMUST00000114987.3
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr6_-_136171722 1.816 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr15_-_8710409 1.708 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_69897255 1.689 ENSMUST00000131553.1
 Ubr3
ubiquitin protein ligase E3 component n-recognin 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 4.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.7 4.0 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.7 2.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.6 2.5 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 2.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.3 2.4 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.8 2.3 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.1 2.3 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.7 2.2 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 2.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 2.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 2.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.3 2.0 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 2.0 GO:0007528 neuromuscular junction development(GO:0007528)
0.3 1.9 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.5 1.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.2 1.8 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 1.8 GO:0031032 actomyosin structure organization(GO:0031032)
0.3 1.7 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 GO:0030427 site of polarized growth(GO:0030427)
0.2 4.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 3.7 GO:0031672 A band(GO:0031672)
0.0 3.0 GO:0042641 actomyosin(GO:0042641)
0.2 2.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.7 GO:0072562 blood microparticle(GO:0072562)
0.0 2.7 GO:0043197 dendritic spine(GO:0043197)
0.3 2.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 2.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.5 2.0 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 1.8 GO:0030139 endocytic vesicle(GO:0030139)
0.1 1.7 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.7 GO:0034704 calcium channel complex(GO:0034704)
0.1 1.5 GO:0071565 nBAF complex(GO:0071565)
0.0 1.5 GO:0016459 myosin complex(GO:0016459)
0.3 1.4 GO:0097487 vesicle lumen(GO:0031983) multivesicular body, internal vesicle(GO:0097487)
0.0 1.4 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.3 GO:0044224 juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 5.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 4.9 GO:0008017 microtubule binding(GO:0008017)
0.1 4.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.3 4.0 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.5 2.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 2.8 GO:0030507 spectrin binding(GO:0030507)
0.1 2.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 2.4 GO:0070412 R-SMAD binding(GO:0070412)
0.1 2.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.3 2.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 2.1 GO:0001968 fibronectin binding(GO:0001968)
0.1 2.0 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 1.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 1.8 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.3 1.7 GO:0008545 JUN kinase kinase activity(GO:0008545)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 4.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.9 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.9 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 1.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.1 ST_ADRENERGIC Adrenergic Pathway
0.0 1.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.7 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.7 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.7 PID_ERBB4_PATHWAY ErbB4 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 4.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 3.5 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 3.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 2.9 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 2.3 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 2.1 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 1.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.7 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.0 1.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.0 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.0 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 0.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.8 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions