Motif ID: Nr0b1

Z-value: 0.940


Transcription factors associated with Nr0b1:

Gene SymbolEntrez IDGene Name
Nr0b1 ENSMUSG00000025056.4 Nr0b1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr0b1mm10_v2_chrX_+_86191764_86191782-0.341.6e-01Click!


Activity profile for motif Nr0b1.

activity profile for motif Nr0b1


Sorted Z-values histogram for motif Nr0b1

Sorted Z-values for motif Nr0b1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr0b1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_19094594 3.904 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr2_-_54085542 2.808 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr16_-_45844303 2.471 ENSMUST00000036355.6
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr16_-_45844228 2.393 ENSMUST00000076333.5
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr5_-_99037035 2.239 ENSMUST00000031277.6
 Prkg2
protein kinase, cGMP-dependent, type II
chr17_-_70851189 2.128 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr5_-_99037342 2.007 ENSMUST00000161490.1
 Prkg2
protein kinase, cGMP-dependent, type II
chrX_-_48034842 1.739 ENSMUST00000039026.7
 Apln
apelin
chr7_+_79500081 1.607 ENSMUST00000181511.2
ENSMUST00000182937.1
 AI854517

expressed sequence AI854517

chr7_+_79500018 1.553 ENSMUST00000182495.1
ENSMUST00000183043.1
 AI854517

expressed sequence AI854517

chr5_+_30913398 1.420 ENSMUST00000031055.5
 Emilin1
elastin microfibril interfacer 1
chr11_+_102604370 1.355 ENSMUST00000057893.5
 Fzd2
frizzled homolog 2 (Drosophila)
chr2_-_65238625 1.351 ENSMUST00000112429.2
ENSMUST00000102726.1
ENSMUST00000112430.1
 Cobll1


Cobl-like 1


chr8_-_105707933 1.253 ENSMUST00000013299.9
 Enkd1
enkurin domain containing 1
chr2_+_30066419 1.186 ENSMUST00000067996.6
 Set
SET nuclear oncogene
chr11_+_94328242 1.182 ENSMUST00000021227.5
 Ankrd40
ankyrin repeat domain 40
chr1_+_42697146 1.145 ENSMUST00000054883.2
 Pou3f3
POU domain, class 3, transcription factor 3
chr14_+_11553523 1.065 ENSMUST00000022264.6
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr2_+_157279065 1.045 ENSMUST00000029171.5
 Rpn2
ribophorin II
chr19_-_46039442 0.966 ENSMUST00000137771.1
 Ldb1
LIM domain binding 1
chr11_+_94327984 0.962 ENSMUST00000107818.2
ENSMUST00000051221.6
 Ankrd40

ankyrin repeat domain 40

chr1_-_9700209 0.921 ENSMUST00000088658.4
 Mybl1
myeloblastosis oncogene-like 1
chr7_+_82867327 0.892 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr5_-_115436508 0.863 ENSMUST00000078701.3
 4930430O22Rik
RIKEN cDNA 4930430O22 gene
chr10_-_81350389 0.843 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
 Hmg20b



high mobility group 20B



chr2_+_157279026 0.773 ENSMUST00000116380.2
 Rpn2
ribophorin II
chr18_+_35829798 0.652 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr17_+_34898463 0.591 ENSMUST00000114033.2
ENSMUST00000078061.6
 Ehmt2

euchromatic histone lysine N-methyltransferase 2

chr11_-_74723829 0.578 ENSMUST00000102520.2
 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr19_+_45015198 0.550 ENSMUST00000179108.1
 Lzts2
leucine zipper, putative tumor suppressor 2
chr4_-_123750236 0.527 ENSMUST00000102636.3
 Akirin1
akirin 1
chr14_+_70457447 0.524 ENSMUST00000003561.3
 Phyhip
phytanoyl-CoA hydroxylase interacting protein
chr17_+_29490812 0.486 ENSMUST00000024811.6
 Pim1
proviral integration site 1
chr8_-_95434869 0.454 ENSMUST00000034249.6
 Gtl3
gene trap locus 3
chr4_-_135971894 0.416 ENSMUST00000105852.1
 Lypla2
lysophospholipase 2
chr13_-_64274879 0.414 ENSMUST00000109770.1
 Cdc14b
CDC14 cell division cycle 14B
chr4_-_132422484 0.386 ENSMUST00000102568.3
 Phactr4
phosphatase and actin regulator 4
chr7_-_65371210 0.384 ENSMUST00000102592.3
 Tjp1
tight junction protein 1
chr18_+_80046854 0.381 ENSMUST00000070219.7
 Pard6g
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr8_-_85080679 0.366 ENSMUST00000093357.5
 Wdr83
WD repeat domain containing 83
chr2_+_4718145 0.359 ENSMUST00000056914.6
 Bend7
BEN domain containing 7
chr14_+_75845296 0.333 ENSMUST00000142061.1
 Tpt1
tumor protein, translationally-controlled 1
chr2_+_85037448 0.320 ENSMUST00000168266.1
ENSMUST00000130729.1
 Ssrp1

structure specific recognition protein 1

chr9_+_57521232 0.307 ENSMUST00000000090.6
 Cox5a
cytochrome c oxidase subunit Va
chr2_+_71786923 0.306 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr11_+_105181793 0.286 ENSMUST00000092537.3
ENSMUST00000015107.6
ENSMUST00000145048.1
 Tlk2


tousled-like kinase 2 (Arabidopsis)


chr2_+_59160884 0.253 ENSMUST00000037903.8
 Pkp4
plakophilin 4
chr13_-_106936907 0.252 ENSMUST00000080856.7
 Ipo11
importin 11
chr3_-_107458895 0.233 ENSMUST00000009617.8
 Kcnc4
potassium voltage gated channel, Shaw-related subfamily, member 4
chr4_+_148130883 0.220 ENSMUST00000084129.2
 Mad2l2
MAD2 mitotic arrest deficient-like 2
chr4_-_132422394 0.216 ENSMUST00000152271.1
ENSMUST00000084170.5
 Phactr4

phosphatase and actin regulator 4

chr10_+_116301374 0.199 ENSMUST00000092167.5
 Ptprb
protein tyrosine phosphatase, receptor type, B
chr11_+_105181527 0.175 ENSMUST00000106941.2
 Tlk2
tousled-like kinase 2 (Arabidopsis)
chr17_-_23745829 0.173 ENSMUST00000046525.8
 Kremen2
kringle containing transmembrane protein 2
chr11_+_77930800 0.170 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr8_-_85080652 0.166 ENSMUST00000152785.1
 Wdr83
WD repeat domain containing 83
chr4_-_129696817 0.160 ENSMUST00000102588.3
 Tmem39b
transmembrane protein 39b
chr18_-_10030017 0.156 ENSMUST00000116669.1
ENSMUST00000092096.6
 Usp14

ubiquitin specific peptidase 14

chr3_+_86224665 0.141 ENSMUST00000107635.1
 Lrba
LPS-responsive beige-like anchor
chr5_-_137531952 0.131 ENSMUST00000140139.1
 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr11_+_50237002 0.116 ENSMUST00000180443.1
 Gm26542
predicted gene, 26542
chr19_-_6077183 0.106 ENSMUST00000025711.5
ENSMUST00000160590.1
 Vps51

vacuolar protein sorting 51 homolog (S. cerevisiae)

chr5_+_31193227 0.102 ENSMUST00000031029.8
ENSMUST00000133711.1
ENSMUST00000132471.1
 Snx17


sorting nexin 17


chr17_-_84790517 0.100 ENSMUST00000112308.2
 Lrpprc
leucine-rich PPR-motif containing
chr13_-_55488038 0.091 ENSMUST00000109921.2
ENSMUST00000109923.2
ENSMUST00000021950.8
 Dbn1


drebrin 1


chr5_-_31193008 0.090 ENSMUST00000114605.1
ENSMUST00000114603.1
 Eif2b4

eukaryotic translation initiation factor 2B, subunit 4 delta

chr5_-_31193105 0.087 ENSMUST00000166769.1
 Eif2b4
eukaryotic translation initiation factor 2B, subunit 4 delta
chr10_+_90829538 0.083 ENSMUST00000179694.2
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr9_-_109059711 0.081 ENSMUST00000061973.4
 Trex1
three prime repair exonuclease 1
chr13_-_29984219 0.064 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr2_-_80581380 0.054 ENSMUST00000111760.2
 Nckap1
NCK-associated protein 1
chr10_+_90829409 0.052 ENSMUST00000182202.1
ENSMUST00000182966.1
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr1_+_140246216 0.051 ENSMUST00000119786.1
ENSMUST00000120796.1
ENSMUST00000060201.8
ENSMUST00000120709.1
 Kcnt2



potassium channel, subfamily T, member 2



chr5_+_110230975 0.038 ENSMUST00000031474.7
ENSMUST00000086674.5
 Ankle2

ankyrin repeat and LEM domain containing 2

chr5_+_121711609 0.034 ENSMUST00000051950.7
 Atxn2
ataxin 2
chr13_-_14063395 0.033 ENSMUST00000170957.1
 Ggps1
geranylgeranyl diphosphate synthase 1
chr10_-_128589650 0.023 ENSMUST00000082059.6
 Erbb3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr11_+_23306884 0.013 ENSMUST00000180046.1
 Usp34
ubiquitin specific peptidase 34
chr19_-_6128208 0.012 ENSMUST00000025702.7
 Snx15
sorting nexin 15
chr2_-_80581234 0.007 ENSMUST00000028386.5
 Nckap1
NCK-associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.9 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.6 4.2 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.6 1.7 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.3 3.9 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.3 1.1 GO:0072236 DCT cell differentiation(GO:0072069) metanephric loop of Henle development(GO:0072236) metanephric DCT cell differentiation(GO:0072240)
0.3 1.4 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.2 1.0 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.2 0.6 GO:0036166 phenotypic switching(GO:0036166)
0.2 0.6 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.6 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 2.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.9 GO:0072697 protein localization to cell cortex(GO:0072697)
0.1 1.4 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.3 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.1 0.5 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.1 0.4 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 0.2 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 0.2 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.1 0.3 GO:0035878 nail development(GO:0035878)
0.0 0.8 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 1.4 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.2 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 0.4 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.5 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0 0.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0010643 cell communication by chemical coupling(GO:0010643) negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.0 0.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.9 GO:1901998 toxin transport(GO:1901998)
0.0 0.2 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 2.8 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.1 GO:0008078 zygotic determination of anterior/posterior axis, embryo(GO:0007354) mesodermal cell migration(GO:0008078)
0.0 1.3 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.0 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.1 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.9 GO:0045180 basal cortex(GO:0045180)
0.2 0.8 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 1.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.6 GO:0000235 astral microtubule(GO:0000235)
0.1 1.7 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.3 GO:0045298 tubulin complex(GO:0045298)
0.0 0.1 GO:1902737 dendritic filopodium(GO:1902737)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 1.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 4.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.3 1.4 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.1 1.8 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.6 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 1.0 GO:0030274 LIM domain binding(GO:0030274)
0.1 2.1 GO:0070410 co-SMAD binding(GO:0070410)
0.1 1.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.6 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 0.3 GO:0038132 neuregulin binding(GO:0038132)
0.1 1.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 0.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.1 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.5 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.8 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.6 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.1 GO:0032405 exodeoxyribonuclease III activity(GO:0008853) MutLalpha complex binding(GO:0032405)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 2.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.6 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.2 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 2.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 0.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.8 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 0.6 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery