Motif ID: Onecut1_Cux2

Z-value: 0.932

Transcription factors associated with Onecut1_Cux2:

Gene SymbolEntrez IDGene Name
Cux2 ENSMUSG00000042589.12 Cux2
Cux2 ENSMUSG00000072641.1 Cux2
Onecut1 ENSMUSG00000043013.9 Onecut1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut1mm10_v2_chr9_+_74861888_748619210.391.1e-01Click!
Cux2mm10_v2_chr5_-_122050102_122050158-0.263.0e-01Click!


Activity profile for motif Onecut1_Cux2.

activity profile for motif Onecut1_Cux2


Sorted Z-values histogram for motif Onecut1_Cux2

Sorted Z-values for motif Onecut1_Cux2



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut1_Cux2

PNG image of the network

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Top targets:


Showing 1 to 20 of 98 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_102010138 3.980 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr12_+_55598917 3.764 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr6_-_23248264 3.000 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr18_+_57468478 2.889 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr10_-_64090265 2.601 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr6_+_4755327 2.516 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr1_-_158958367 2.074 ENSMUST00000159861.2
 Pappa2
pappalysin 2
chr10_-_64090241 1.786 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr14_+_68083853 1.708 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr10_-_112928974 1.171 ENSMUST00000099276.2
 Atxn7l3b
ataxin 7-like 3B
chr8_+_58911755 1.070 ENSMUST00000062978.6
 BC030500
cDNA sequence BC030500
chr19_-_57197496 0.956 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chr7_+_75848338 0.954 ENSMUST00000092073.5
ENSMUST00000171155.2
 Klhl25

kelch-like 25

chr9_-_114844090 0.827 ENSMUST00000047013.3
 Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr19_-_57197377 0.751 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr12_-_84698769 0.748 ENSMUST00000095550.2
 Syndig1l
synapse differentiation inducing 1 like
chr2_-_72986716 0.693 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr13_+_93304940 0.660 ENSMUST00000109497.1
ENSMUST00000109498.1
ENSMUST00000060490.4
ENSMUST00000109492.1
ENSMUST00000109496.1
ENSMUST00000109495.1
 Homer1





homer homolog 1 (Drosophila)





chr19_-_57197556 0.636 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr3_+_8509477 0.561 ENSMUST00000029002.7
 Stmn2
stathmin-like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.4 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 4.0 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.5 3.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 2.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 2.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.6 1.7 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.1 1.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 0.9 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.0 0.9 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 0.8 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.8 GO:0006446 regulation of translational initiation(GO:0006446)
0.2 0.6 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.6 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 0.5 GO:0006553 lysine metabolic process(GO:0006553)
0.2 0.5 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.0 0.5 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 0.4 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.4 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0 0.4 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.1 0.3 GO:0006657 CDP-choline pathway(GO:0006657)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 2.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.6 1.7 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.9 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.1 0.4 GO:0044308 axonal spine(GO:0044308)
0.1 0.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.3 GO:0042587 glycogen granule(GO:0042587)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.1 0.2 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.0 0.2 GO:0032127 dense core granule membrane(GO:0032127)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.1 GO:0030122 AP-2 adaptor complex(GO:0030122)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 4.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 3.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.7 GO:0043274 phospholipase binding(GO:0043274)
0.1 1.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 1.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 0.9 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.5 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 0.4 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.4 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.3 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.3 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:1990226 histone methyltransferase binding(GO:1990226)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.5 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions