Motif ID: Hes5_Hes7

Z-value: 1.158

Transcription factors associated with Hes5_Hes7:

Gene SymbolEntrez IDGene Name
Hes5 ENSMUSG00000048001.7 Hes5
Hes7 ENSMUSG00000023781.2 Hes7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes5mm10_v2_chr4_+_154960915_1549609300.781.3e-04Click!
Hes7mm10_v2_chr11_+_69120404_69120404-0.401.0e-01Click!


Activity profile for motif Hes5_Hes7.

activity profile for motif Hes5_Hes7


Sorted Z-values histogram for motif Hes5_Hes7

Sorted Z-values for motif Hes5_Hes7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes5_Hes7

PNG image of the network

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Top targets:


Showing 1 to 20 of 93 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 15.721 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 14.726 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr10_-_87493651 3.606 ENSMUST00000020243.7
 Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr12_-_56536895 3.357 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr15_+_72913357 2.444 ENSMUST00000166418.2
 Gm3150
predicted gene 3150
chr12_+_109459843 2.339 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr13_+_51846673 2.158 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr8_-_87804411 2.148 ENSMUST00000165770.2
 Zfp423
zinc finger protein 423
chr4_-_132757162 2.123 ENSMUST00000030709.8
 Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
chr6_+_4755327 1.952 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr4_+_137913471 1.861 ENSMUST00000151110.1
 Ece1
endothelin converting enzyme 1
chr2_+_163203072 1.590 ENSMUST00000109428.2
 Tox2
TOX high mobility group box family member 2
chr13_+_108316395 1.588 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr1_+_72824482 1.574 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr13_+_108316332 1.485 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr11_+_59306920 1.419 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr9_+_64121501 1.362 ENSMUST00000118215.1
 Lctl
lactase-like
chr10_+_79682169 1.336 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr2_+_73271925 1.319 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr5_+_128601106 1.304 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 30.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
1.2 3.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
1.1 3.4 GO:0021759 globus pallidus development(GO:0021759)
0.0 3.1 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.3 2.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 2.3 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.2 2.2 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.3 2.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 2.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 2.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.6 1.9 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.1 1.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 1.4 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.2 1.3 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 1.3 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 1.3 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.1 1.2 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.3 1.0 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 1.0 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.2 0.8 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.4 GO:0016607 nuclear speck(GO:0016607)
0.0 2.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.4 1.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.3 GO:0005581 collagen trimer(GO:0005581)
0.0 1.3 GO:0005657 replication fork(GO:0005657)
0.0 1.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.0 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.8 GO:0005652 nuclear lamina(GO:0005652)
0.1 0.7 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.6 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.6 GO:0016600 flotillin complex(GO:0016600)
0.1 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 30.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 3.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.3 3.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 2.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 2.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.3 2.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 1.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.3 1.4 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)
0.4 1.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 1.2 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.2 1.0 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 0.6 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.0 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 0.5 GO:0015140 malate transmembrane transporter activity(GO:0015140)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 30.4 PID_IGF1_PATHWAY IGF1 pathway
0.1 5.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 2.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.2 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 2.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.0 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.6 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 30.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 3.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 1.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 0.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.7 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.3 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.0 0.2 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1