Motif ID: E2f6

Z-value: 1.310


Transcription factors associated with E2f6:

Gene SymbolEntrez IDGene Name
E2f6 ENSMUSG00000057469.7 E2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f6mm10_v2_chr12_+_16810940_168109780.881.2e-06Click!


Activity profile for motif E2f6.

activity profile for motif E2f6


Sorted Z-values histogram for motif E2f6

Sorted Z-values for motif E2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 6.612 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr15_-_98004695 3.829 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr13_+_48261427 3.807 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr15_-_98004634 3.552 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr19_-_45742873 3.536 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr7_+_144838590 2.813 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr6_+_42350000 2.769 ENSMUST00000164375.1
 Zyx
zyxin
chr2_+_164562579 2.701 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr7_+_102441685 2.678 ENSMUST00000033283.9
 Rrm1
ribonucleotide reductase M1
chr5_+_139543889 2.484 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_+_42349826 2.446 ENSMUST00000070635.6
 Zyx
zyxin
chr13_+_112987802 2.433 ENSMUST00000038404.4
 Ccno
cyclin O
chrX_+_142681398 2.376 ENSMUST00000112889.1
ENSMUST00000101198.2
ENSMUST00000112891.1
ENSMUST00000087333.2
 Tmem164



transmembrane protein 164



chrX_-_52613913 2.243 ENSMUST00000069360.7
 Gpc3
glypican 3
chr7_-_38107490 2.239 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr12_+_8771317 2.156 ENSMUST00000020911.7
 Sdc1
syndecan 1
chrX_-_52613936 2.155 ENSMUST00000114857.1
 Gpc3
glypican 3
chr6_+_108660616 2.001 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr1_+_74771886 1.978 ENSMUST00000006716.6
 Wnt6
wingless-related MMTV integration site 6
chr5_+_137350101 1.922 ENSMUST00000061244.8
 Ephb4
Eph receptor B4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 405 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 8.9 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.2 7.5 GO:0006270 DNA replication initiation(GO:0006270)
0.4 6.8 GO:0007530 sex determination(GO:0007530)
0.2 5.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 5.8 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.6 4.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 4.7 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
1.5 4.4 GO:0072180 mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
1.1 4.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
1.3 4.0 GO:0030421 defecation(GO:0030421)
0.1 4.0 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.6 3.8 GO:0030916 otic vesicle formation(GO:0030916)
0.9 3.7 GO:0015888 thiamine transport(GO:0015888)
0.9 3.6 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
1.2 3.5 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.9 3.4 GO:0003360 brainstem development(GO:0003360)
0.6 3.1 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.2 3.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 3.1 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.6 3.0 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.1 GO:0000791 euchromatin(GO:0000791)
0.7 8.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 7.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 7.0 GO:0031225 anchored component of membrane(GO:0031225)
1.2 5.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 4.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 4.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.3 3.9 GO:0042555 MCM complex(GO:0042555)
0.0 3.1 GO:0005884 actin filament(GO:0005884)
1.0 3.0 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.4 3.0 GO:0001740 Barr body(GO:0001740)
0.1 2.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.2 2.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 2.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 2.4 GO:0071564 npBAF complex(GO:0071564)
0.1 2.4 GO:0060170 ciliary membrane(GO:0060170)
0.0 2.3 GO:0001650 fibrillar center(GO:0001650)
0.7 2.0 GO:0033186 CAF-1 complex(GO:0033186)
0.1 2.0 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 244 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 7.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.5 7.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.3 7.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
1.2 5.8 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.6 4.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 4.5 GO:0070888 E-box binding(GO:0070888)
0.0 4.5 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 4.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 4.1 GO:0005178 integrin binding(GO:0005178)
0.8 4.0 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
1.2 3.7 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 3.7 GO:0005109 frizzled binding(GO:0005109)
1.1 3.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.5 3.3 GO:0043426 MRF binding(GO:0043426)
0.6 3.0 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.5 3.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 2.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.6 2.4 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.1 2.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.0 PID_E2F_PATHWAY E2F transcription factor network
0.2 9.6 NABA_COLLAGENS Genes encoding collagen proteins
0.1 6.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 6.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 5.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 5.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 5.2 PID_ALK1_PATHWAY ALK1 signaling events
0.1 5.1 PID_FGF_PATHWAY FGF signaling pathway
0.2 5.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 5.0 PID_ATR_PATHWAY ATR signaling pathway
0.1 4.7 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 4.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 4.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 4.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 4.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.2 3.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 3.8 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 3.7 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 3.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 3.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 10.2 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.6 7.3 REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 Genes involved in Activated point mutants of FGFR2
0.4 7.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 7.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 5.6 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.3 4.3 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.2 4.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 4.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 3.8 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 3.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 3.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.3 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 2.8 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 2.6 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 2.5 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.2 2.4 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 2.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors