Motif ID: Mef2c

Z-value: 1.003


Transcription factors associated with Mef2c:

Gene SymbolEntrez IDGene Name
Mef2c ENSMUSG00000005583.10 Mef2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2cmm10_v2_chr13_+_83573577_835736070.822.6e-05Click!


Activity profile for motif Mef2c.

activity profile for motif Mef2c


Sorted Z-values histogram for motif Mef2c

Sorted Z-values for motif Mef2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 171 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 5.539 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr19_-_5802640 5.131 ENSMUST00000173523.1
ENSMUST00000173499.1
ENSMUST00000172812.2
 Malat1


metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


chr13_+_83573577 4.968 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr4_+_144893077 4.373 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr5_+_75152274 4.278 ENSMUST00000000476.8
 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr10_+_69785507 3.972 ENSMUST00000182993.1
 Ank3
ankyrin 3, epithelial
chr4_+_144893127 3.804 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr12_-_34528844 3.377 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chrX_-_51681703 3.363 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chrX_-_51681856 3.201 ENSMUST00000114871.1
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr6_+_108213086 2.877 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr13_+_16011851 2.871 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr5_-_122002340 2.858 ENSMUST00000134326.1
 Cux2
cut-like homeobox 2
chr7_+_91090697 2.840 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 2.791 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr16_+_45093611 2.748 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr5_+_66745835 2.598 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
 Limch1



LIM and calponin homology domains 1



chr3_-_85722474 2.526 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr4_+_130308595 2.514 ENSMUST00000070532.7
 Fabp3
fatty acid binding protein 3, muscle and heart
chr1_-_64122256 2.420 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 13.7 GO:0042572 retinol metabolic process(GO:0042572)
0.9 10.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.1 6.6 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.4 5.6 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.4 5.5 GO:0001553 luteinization(GO:0001553)
1.0 5.1 GO:0035063 nuclear speck organization(GO:0035063)
1.7 5.0 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.0 4.9 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 4.8 GO:0007019 microtubule depolymerization(GO:0007019)
1.4 4.3 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.4 3.4 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 3.2 GO:0048813 dendrite morphogenesis(GO:0048813)
0.6 2.9 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.3 2.9 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 2.9 GO:0007614 short-term memory(GO:0007614)
0.6 2.5 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.3 2.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 2.4 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.7 2.0 GO:0007525 somatic muscle development(GO:0007525)
0.1 2.0 GO:0090129 positive regulation of synapse maturation(GO:0090129)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 10.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 6.3 GO:0016607 nuclear speck(GO:0016607)
0.1 6.0 GO:0032587 ruffle membrane(GO:0032587)
0.3 5.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 3.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 3.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
1.0 2.9 GO:0031088 platelet dense granule membrane(GO:0031088)
1.0 2.9 GO:0043512 inhibin A complex(GO:0043512)
0.0 2.9 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 2.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.8 GO:0016324 apical plasma membrane(GO:0016324)
0.2 2.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.5 GO:0001650 fibrillar center(GO:0001650)
0.1 2.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 2.2 GO:0043194 axon initial segment(GO:0043194)
0.1 2.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.0 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.8 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 13.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 11.9 GO:0030507 spectrin binding(GO:0030507)
1.6 6.6 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 5.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.3 5.0 GO:0003680 AT DNA binding(GO:0003680)
0.2 4.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.9 4.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.7 4.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 3.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 3.2 GO:0015631 tubulin binding(GO:0015631)
1.0 2.9 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 2.8 GO:0042805 actinin binding(GO:0042805)
0.1 2.7 GO:0001968 fibronectin binding(GO:0001968)
0.0 2.7 GO:0030674 protein binding, bridging(GO:0030674)
0.5 2.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 2.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 2.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 2.4 GO:0008083 growth factor activity(GO:0008083)
0.0 1.9 GO:0051018 protein kinase A binding(GO:0051018)
0.1 1.8 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 5.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 3.3 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 2.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.9 PID_ALK1_PATHWAY ALK1 signaling events
0.0 2.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 2.0 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.5 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.4 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 0.9 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 0.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.6 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 6.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 6.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 5.8 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.7 2.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.7 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.6 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 1.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.5 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 1.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 1.4 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.9 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 0.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.8 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 0.7 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.7 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 0.6 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.6 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway