Motif ID: Zfp219_Zfp740

Z-value: 1.208

Transcription factors associated with Zfp219_Zfp740:

Gene SymbolEntrez IDGene Name
Zfp219 ENSMUSG00000049295.10 Zfp219
Zfp740 ENSMUSG00000046897.10 Zfp740

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp740mm10_v2_chr15_+_102203639_1022037090.663.0e-03Click!
Zfp219mm10_v2_chr14_-_52020698_52020737-0.087.6e-01Click!


Activity profile for motif Zfp219_Zfp740.

activity profile for motif Zfp219_Zfp740


Sorted Z-values histogram for motif Zfp219_Zfp740

Sorted Z-values for motif Zfp219_Zfp740



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp219_Zfp740

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_127620922 4.928 ENSMUST00000118455.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr10_-_127620960 4.165 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr3_+_28263563 4.104 ENSMUST00000160307.2
ENSMUST00000159680.2
ENSMUST00000160518.1
ENSMUST00000162485.1
ENSMUST00000159308.1
ENSMUST00000162777.1
ENSMUST00000161964.1
 Tnik






TRAF2 and NCK interacting kinase






chr7_+_127511976 3.588 ENSMUST00000098025.4
 Srcap
Snf2-related CREBBP activator protein
chr2_+_48949495 3.508 ENSMUST00000112745.1
 Mbd5
methyl-CpG binding domain protein 5
chr12_+_102949450 3.323 ENSMUST00000179002.1
 Unc79
unc-79 homolog (C. elegans)
chr7_+_127777095 3.194 ENSMUST00000144406.1
 Setd1a
SET domain containing 1A
chr1_-_56972437 3.090 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr16_+_44173271 2.939 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr11_-_69369377 2.827 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr13_-_29984219 2.489 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr4_+_152338619 2.426 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr7_-_78578308 2.414 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr19_-_59170978 2.387 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr12_-_27342696 2.227 ENSMUST00000079063.5
 Sox11
SRY-box containing gene 11
chr7_-_78577771 2.224 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr1_-_64121389 2.189 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr9_-_44881274 2.161 ENSMUST00000002095.3
ENSMUST00000114689.1
ENSMUST00000128768.1
 Kmt2a


lysine (K)-specific methyltransferase 2A


chr4_+_152338887 2.110 ENSMUST00000005175.4
 Chd5
chromodomain helicase DNA binding protein 5
chr18_-_43393346 2.105 ENSMUST00000025379.7
 Dpysl3
dihydropyrimidinase-like 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 207 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 10.0 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.4 6.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.0 5.0 GO:0007256 activation of JNKK activity(GO:0007256)
1.5 4.6 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
1.1 4.6 GO:1904048 regulation of spontaneous neurotransmitter secretion(GO:1904048)
0.6 4.5 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 4.1 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.4 3.9 GO:0048149 behavioral response to ethanol(GO:0048149)
0.4 3.9 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.2 3.9 GO:1990403 embryonic brain development(GO:1990403)
1.2 3.5 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.5 3.1 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 3.0 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.7 2.9 GO:0043974 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.3 2.8 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.4 2.5 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 2.5 GO:0007520 myoblast fusion(GO:0007520)
0.1 2.5 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.7 2.2 GO:0060023 soft palate development(GO:0060023)
0.0 2.2 GO:0006284 base-excision repair(GO:0006284)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.3 6.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 6.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 6.0 GO:0055037 recycling endosome(GO:0055037)
0.0 5.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 3.9 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 3.9 GO:0035869 ciliary transition zone(GO:0035869)
0.2 3.8 GO:0010369 chromocenter(GO:0010369)
0.2 3.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.7 3.3 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 2.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 2.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.5 2.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 2.5 GO:0043235 receptor complex(GO:0043235)
0.0 2.4 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 2.2 GO:0035861 site of double-strand break(GO:0035861)
0.1 2.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 1.9 GO:0032584 growth cone membrane(GO:0032584)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 10.0 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.0 5.6 GO:0005096 GTPase activator activity(GO:0005096)
0.4 5.0 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.9 4.6 GO:0005030 neurotrophin receptor activity(GO:0005030)
1.1 4.5 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.8 3.9 GO:1990188 euchromatin binding(GO:1990188)
0.2 3.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 3.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.9 GO:0008017 microtubule binding(GO:0008017)
0.2 2.8 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.5 2.7 GO:0045322 unmethylated CpG binding(GO:0045322)
0.3 2.6 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.3 2.6 GO:0001093 TFIIB-class transcription factor binding(GO:0001093)
0.1 2.6 GO:0070412 R-SMAD binding(GO:0070412)
0.3 2.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 2.4 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 2.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 2.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.3 1.9 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.9 GO:0001222 transcription corepressor binding(GO:0001222)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.7 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 4.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 3.9 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 3.8 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 3.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 3.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.9 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 2.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 2.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 2.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 1.5 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 0.9 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.9 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 0.8 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 0.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 2.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 2.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 1.9 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 1.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.2 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 0.9 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 0.9 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.9 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.9 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 0.8 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 0.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels