Motif ID: Etv3_Erf_Fev_Elk4_Elk1_Elk3

Z-value: 1.157

Transcription factors associated with Etv3_Erf_Fev_Elk4_Elk1_Elk3:

Gene SymbolEntrez IDGene Name
Elk1 ENSMUSG00000009406.7 Elk1
Elk3 ENSMUSG00000008398.8 Elk3
Elk4 ENSMUSG00000026436.9 Elk4
Erf ENSMUSG00000040857.9 Erf
Etv3 ENSMUSG00000003382.12 Etv3
Fev ENSMUSG00000055197.4 Fev

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elk1mm10_v2_chrX_-_20950597_209506130.807.9e-05Click!
Elk4mm10_v2_chr1_+_132007606_1320076340.781.5e-04Click!
Etv3mm10_v2_chr3_+_87525572_875256430.644.1e-03Click!
Erfmm10_v2_chr7_-_25250720_25250761-0.484.4e-02Click!
Elk3mm10_v2_chr10_-_93311073_933111610.331.8e-01Click!


Activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3.

activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3


Sorted Z-values histogram for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3

Sorted Z-values for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv3_Erf_Fev_Elk4_Elk1_Elk3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_163602331 8.327 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr11_+_54522872 5.003 ENSMUST00000108895.1
ENSMUST00000101206.3
 Rapgef6

Rap guanine nucleotide exchange factor (GEF) 6

chr12_+_80644212 4.779 ENSMUST00000085245.5
 Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr8_-_69791170 4.523 ENSMUST00000131784.1
 Zfp866
zinc finger protein 866
chr12_-_84970814 4.431 ENSMUST00000165886.1
ENSMUST00000167448.1
ENSMUST00000043169.7
 Arel1


apoptosis resistant E3 ubiquitin protein ligase 1


chr17_+_35135463 4.320 ENSMUST00000173535.1
ENSMUST00000173952.1
 Bag6

BCL2-associated athanogene 6

chr17_+_33955902 4.232 ENSMUST00000173196.2
 Vps52
vacuolar protein sorting 52 (yeast)
chr9_-_110476637 4.182 ENSMUST00000111934.1
ENSMUST00000068025.6
 Klhl18

kelch-like 18

chr6_+_86849488 3.973 ENSMUST00000089519.6
ENSMUST00000113668.1
 Aak1

AP2 associated kinase 1

chr1_-_133025330 3.960 ENSMUST00000067429.3
ENSMUST00000067398.6
 Mdm4

transformed mouse 3T3 cell double minute 4

chr18_-_84589491 3.937 ENSMUST00000125763.1
 Zfp407
zinc finger protein 407
chr6_+_8259288 3.928 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr17_+_35135196 3.874 ENSMUST00000172571.1
ENSMUST00000173491.1
 Bag6

BCL2-associated athanogene 6

chr7_+_127876796 3.709 ENSMUST00000131000.1
 Zfp646
zinc finger protein 646
chr4_-_122885965 3.679 ENSMUST00000128485.1
 Cap1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr9_+_56418624 3.622 ENSMUST00000034879.3
 Hmg20a
high mobility group 20A
chr12_-_64965496 3.622 ENSMUST00000021331.7
 Klhl28
kelch-like 28
chr11_+_83299005 3.563 ENSMUST00000176944.1
 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr9_-_29411736 3.496 ENSMUST00000115236.1
 Ntm
neurotrimin
chr10_-_83648631 3.473 ENSMUST00000146876.2
ENSMUST00000176294.1
 Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 425 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 11.1 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.6 9.8 GO:0060363 cranial suture morphogenesis(GO:0060363)
1.0 9.3 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.2 8.4 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.4 7.9 GO:0030033 microvillus assembly(GO:0030033)
2.5 7.4 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.2 7.3 GO:0006829 zinc II ion transport(GO:0006829)
0.4 6.1 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 5.4 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
1.1 5.3 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.2 5.0 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 4.9 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.1 4.7 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 4.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
1.5 4.4 GO:0019085 early viral transcription(GO:0019085)
1.1 4.4 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.3 4.2 GO:0030157 pancreatic juice secretion(GO:0030157)
0.3 4.0 GO:0003283 atrial septum development(GO:0003283)
0.1 4.0 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.4 3.9 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.8 GO:0030131 clathrin adaptor complex(GO:0030131)
1.6 11.1 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
1.2 9.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 9.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
1.8 8.9 GO:1990745 EARP complex(GO:1990745)
0.1 8.4 GO:0005802 trans-Golgi network(GO:0005802)
0.2 8.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 7.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 6.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 5.9 GO:0030139 endocytic vesicle(GO:0030139)
0.3 5.7 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.9 5.4 GO:0097443 sorting endosome(GO:0097443)
1.3 5.3 GO:1990769 proximal neuron projection(GO:1990769)
0.0 5.3 GO:0005768 endosome(GO:0005768)
0.6 5.0 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 5.0 GO:0005769 early endosome(GO:0005769)
0.5 4.9 GO:0071439 clathrin complex(GO:0071439)
0.0 4.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 4.2 GO:0031225 anchored component of membrane(GO:0031225)
0.5 4.1 GO:0097427 microtubule bundle(GO:0097427)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 247 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 29.3 GO:0008270 zinc ion binding(GO:0008270)
0.2 25.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 21.1 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2 11.3 GO:0070063 RNA polymerase binding(GO:0070063)
0.2 11.3 GO:0030276 clathrin binding(GO:0030276)
0.8 10.6 GO:0015643 toxic substance binding(GO:0015643)
0.0 9.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.5 9.4 GO:0070300 phosphatidic acid binding(GO:0070300)
0.4 8.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.2 4.9 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 4.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.5 4.5 GO:0071253 connexin binding(GO:0071253)
1.1 4.4 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.0 4.3 GO:0017124 SH3 domain binding(GO:0017124)
0.1 4.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 4.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 4.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 4.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 4.1 GO:0046873 metal ion transmembrane transporter activity(GO:0046873)
0.2 4.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 5.3 SIG_CHEMOTAXIS Genes related to chemotaxis
0.2 5.2 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 4.8 PID_INSULIN_PATHWAY Insulin Pathway
0.1 4.7 PID_ATM_PATHWAY ATM pathway
0.1 4.7 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 3.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 3.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 3.4 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 3.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.8 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.3 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 2.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 2.2 PID_ARF_3PATHWAY Arf1 pathway
0.0 2.1 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 1.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.1 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.6 8.1 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 7.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 7.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 7.0 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.6 6.6 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.4 6.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 5.9 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.2 4.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 3.4 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.1 3.1 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 3.1 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.2 3.0 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 2.9 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.2 2.8 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 2.7 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.2 2.5 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 2.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 2.4 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 2.4 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell