Motif ID: Trp73

Z-value: 0.923


Transcription factors associated with Trp73:

Gene SymbolEntrez IDGene Name
Trp73 ENSMUSG00000029026.10 Trp73

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp73mm10_v2_chr4_-_154097105_1540971730.873.5e-06Click!


Activity profile for motif Trp73.

activity profile for motif Trp73


Sorted Z-values histogram for motif Trp73

Sorted Z-values for motif Trp73



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp73

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_48261427 5.848 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr15_+_99055164 4.561 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr1_+_72824482 3.286 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr17_+_29090969 2.851 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr12_-_45074112 2.644 ENSMUST00000120531.1
ENSMUST00000143376.1
 Stxbp6

syntaxin binding protein 6 (amisyn)

chr16_-_17125106 2.624 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr1_+_153665274 2.621 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr7_-_116308241 2.268 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr12_-_45074457 1.926 ENSMUST00000053768.6
 Stxbp6
syntaxin binding protein 6 (amisyn)
chr7_-_141443314 1.739 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr3_+_159839729 1.576 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr2_-_164857542 1.543 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
 Pltp



phospholipid transfer protein



chr9_-_67760208 1.522 ENSMUST00000068526.5
 M5C1000I18Rik
RIKEN cDNA M5C1000I18 gene
chr2_-_164857671 1.517 ENSMUST00000059954.7
 Pltp
phospholipid transfer protein
chrX_+_10717390 1.464 ENSMUST00000115524.1
ENSMUST00000008179.6
 Mid1ip1

Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))

chr19_+_41911851 1.336 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr4_+_129820198 1.259 ENSMUST00000030578.7
 Ptp4a2
protein tyrosine phosphatase 4a2
chr12_+_109747903 1.248 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr3_+_89245952 1.220 ENSMUST00000040888.5
 Krtcap2
keratinocyte associated protein 2
chr9_-_109082372 1.206 ENSMUST00000167504.1
 Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr1_-_5070281 1.133 ENSMUST00000147158.1
ENSMUST00000118000.1
 Rgs20

regulator of G-protein signaling 20

chr4_+_101068983 1.126 ENSMUST00000038463.8
ENSMUST00000106955.1
 Raver2

ribonucleoprotein, PTB-binding 2

chr3_+_14641722 1.121 ENSMUST00000029071.8
 Car13
carbonic anhydrase 13
chr2_+_34772089 1.092 ENSMUST00000028222.6
ENSMUST00000100171.2
 Hspa5

heat shock protein 5

chr7_+_140881898 1.090 ENSMUST00000026560.7
 Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr15_+_76696725 1.067 ENSMUST00000023203.4
 Gpt
glutamic pyruvic transaminase, soluble
chr11_+_98026918 0.995 ENSMUST00000017548.6
 Rpl19
ribosomal protein L19
chr7_-_116038734 0.994 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr14_+_53665912 0.992 ENSMUST00000181768.1
 Trav3-3
T cell receptor alpha variable 3-3
chrX_+_10717451 0.970 ENSMUST00000156321.1
 Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr4_-_11386757 0.959 ENSMUST00000108313.1
ENSMUST00000108311.2
 Esrp1

epithelial splicing regulatory protein 1

chr14_-_52104015 0.940 ENSMUST00000111610.4
ENSMUST00000164655.1
 Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chr2_+_150909565 0.938 ENSMUST00000028948.4
 Gins1
GINS complex subunit 1 (Psf1 homolog)
chr7_+_140882430 0.909 ENSMUST00000164681.1
ENSMUST00000163610.1
 Psmd13

proteasome (prosome, macropain) 26S subunit, non-ATPase, 13

chr19_-_50030735 0.905 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chrX_-_109013389 0.884 ENSMUST00000033597.8
 Hmgn5
high-mobility group nucleosome binding domain 5
chr8_-_70659645 0.870 ENSMUST00000070173.7
 Pgpep1
pyroglutamyl-peptidase I
chr11_-_102230091 0.858 ENSMUST00000008999.5
 Hdac5
histone deacetylase 5
chr11_-_102230127 0.821 ENSMUST00000107150.1
ENSMUST00000156337.1
ENSMUST00000107151.2
ENSMUST00000107152.2
 Hdac5



histone deacetylase 5



chr7_-_5014645 0.720 ENSMUST00000165320.1
 Fiz1
Flt3 interacting zinc finger protein 1
chr11_+_60931998 0.680 ENSMUST00000019076.3
 Map2k3
mitogen-activated protein kinase kinase 3
chr10_+_127642975 0.679 ENSMUST00000092074.5
ENSMUST00000120279.1
 Stat6

signal transducer and activator of transcription 6

chr2_-_90904827 0.639 ENSMUST00000005647.3
 Ndufs3
NADH dehydrogenase (ubiquinone) Fe-S protein 3
chr10_+_41810528 0.637 ENSMUST00000099931.3
 Sesn1
sestrin 1
chr11_+_69913888 0.531 ENSMUST00000072581.2
ENSMUST00000116358.1
 Gps2

G protein pathway suppressor 2

chr4_-_45489794 0.496 ENSMUST00000146236.1
 Shb
src homology 2 domain-containing transforming protein B
chr13_+_12702362 0.477 ENSMUST00000104944.2
 Gm2399
predicted gene 2399
chr2_-_180920925 0.431 ENSMUST00000037299.8
ENSMUST00000108876.2
 Ythdf1

YTH domain family 1

chr18_+_56432116 0.423 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr1_+_55088132 0.412 ENSMUST00000075242.6
 Hspe1
heat shock protein 1 (chaperonin 10)
chr9_+_108662098 0.395 ENSMUST00000035222.5
 Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr11_+_114851507 0.376 ENSMUST00000177952.1
 Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr5_-_36748639 0.356 ENSMUST00000071949.3
 Bloc1s4
biogenesis of organelles complex-1, subunit 4, cappuccino
chr4_+_62583568 0.350 ENSMUST00000098031.3
 Rgs3
regulator of G-protein signaling 3
chrX_-_10216918 0.321 ENSMUST00000072393.2
ENSMUST00000044598.6
ENSMUST00000073392.4
ENSMUST00000115533.1
ENSMUST00000115532.1
 Rpgr




retinitis pigmentosa GTPase regulator




chr8_+_27085835 0.319 ENSMUST00000165366.2
 Gpr124
G protein-coupled receptor 124
chr19_+_46304709 0.312 ENSMUST00000073116.5
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr11_+_57801575 0.302 ENSMUST00000020826.5
 Sap30l
SAP30-like
chr19_-_7483212 0.248 ENSMUST00000088169.5
 Rtn3
reticulon 3
chr19_-_7483241 0.248 ENSMUST00000025667.6
ENSMUST00000065304.5
ENSMUST00000088171.4
 Rtn3


reticulon 3


chr1_-_55088024 0.245 ENSMUST00000027123.8
 Hspd1
heat shock protein 1 (chaperonin)
chr10_-_127311740 0.227 ENSMUST00000037290.5
ENSMUST00000171564.1
 Mars

methionine-tRNA synthetase

chr4_-_106804998 0.216 ENSMUST00000065253.6
 Acot11
acyl-CoA thioesterase 11
chr3_-_89402650 0.212 ENSMUST00000168325.1
ENSMUST00000057431.5
 Lenep

lens epithelial protein

chr11_-_100738153 0.202 ENSMUST00000155500.1
ENSMUST00000107364.1
ENSMUST00000019317.5
 Rab5c


RAB5C, member RAS oncogene family


chr7_+_25282179 0.175 ENSMUST00000163320.1
ENSMUST00000005578.6
 Cic

capicua homolog (Drosophila)

chr7_-_65371210 0.164 ENSMUST00000102592.3
 Tjp1
tight junction protein 1
chr1_-_12991109 0.163 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr11_-_103344651 0.149 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr10_+_39369750 0.148 ENSMUST00000063091.6
ENSMUST00000099967.3
ENSMUST00000126486.1
 Fyn


Fyn proto-oncogene


chr5_-_92083667 0.111 ENSMUST00000113127.3
 G3bp2
GTPase activating protein (SH3 domain) binding protein 2
chr1_-_170215380 0.072 ENSMUST00000027979.7
ENSMUST00000123399.1
 Uhmk1

U2AF homology motif (UHM) kinase 1

chr3_-_107931579 0.068 ENSMUST00000133947.2
ENSMUST00000124215.1
ENSMUST00000106688.1
ENSMUST00000106687.2
 Gstm7



glutathione S-transferase, mu 7



chr5_-_92083455 0.064 ENSMUST00000169094.1
ENSMUST00000167918.1
 G3bp2

GTPase activating protein (SH3 domain) binding protein 2

chr8_-_85067982 0.051 ENSMUST00000177563.1
 Gm5741
predicted gene 5741
chr1_+_170214826 0.032 ENSMUST00000159201.1
ENSMUST00000055830.1
 4930500M09Rik

RIKEN cDNA 4930500M09 gene

chr10_-_67912620 0.026 ENSMUST00000064656.7
 Zfp365
zinc finger protein 365
chr6_+_83054653 0.012 ENSMUST00000092618.6
 Aup1
ancient ubiquitous protein 1
chr10_+_105841064 0.011 ENSMUST00000020049.8
 Ccdc59
coiled-coil domain containing 59
chr6_+_29398920 0.000 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 5.8 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.8 3.1 GO:0042360 vitamin E metabolic process(GO:0042360)
0.6 4.6 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.5 1.6 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.4 1.3 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.4 2.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.4 1.1 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.3 2.9 GO:0071493 cellular response to UV-B(GO:0071493)
0.2 0.9 GO:0090365 regulation of mRNA modification(GO:0090365)
0.2 3.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 2.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 0.7 GO:0048289 interleukin-4-mediated signaling pathway(GO:0035771) isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.2 1.7 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 2.4 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.1 2.0 GO:0043248 proteasome assembly(GO:0043248)
0.1 4.6 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.1 0.9 GO:1902969 mitotic DNA replication(GO:1902969)
0.1 1.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 1.2 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.1 0.5 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.1 0.4 GO:0015879 carnitine transport(GO:0015879)
0.1 0.5 GO:1900194 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0 0.6 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 1.0 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 1.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.4 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0 0.5 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.4 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.3 GO:0002467 germinal center formation(GO:0002467)
0.0 0.1 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.4 GO:0032438 melanosome organization(GO:0032438) pigment granule organization(GO:0048753)
0.0 0.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.2 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.5 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.7 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0044299 C-fiber(GO:0044299)
1.0 2.9 GO:0070557 PCNA-p21 complex(GO:0070557)
0.3 0.9 GO:0000811 GINS complex(GO:0000811)
0.2 4.6 GO:0000145 exocyst(GO:0000145)
0.2 1.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.2 2.3 GO:0005915 zonula adherens(GO:0005915)
0.2 2.0 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.6 GO:0061700 GATOR2 complex(GO:0061700)
0.1 1.6 GO:0032590 dendrite membrane(GO:0032590)
0.0 2.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.9 GO:0045120 pronucleus(GO:0045120)
0.0 0.4 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.4 1.3 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.4 3.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.3 4.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 1.7 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.2 2.3 GO:0070097 delta-catenin binding(GO:0070097)
0.2 1.0 GO:1990932 5.8S rRNA binding(GO:1990932)
0.2 1.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 1.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.9 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.6 GO:0070728 leucine binding(GO:0070728)
0.1 0.4 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 1.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 1.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 2.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.9 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 1.1 GO:0008483 transaminase activity(GO:0008483)
0.0 1.1 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0005118 sevenless binding(GO:0005118)
0.0 5.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 6.5 GO:0005198 structural molecule activity(GO:0005198)
0.0 1.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.3 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.7 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 2.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.7 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.1 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.7 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.1 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 2.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 ST_GAQ_PATHWAY G alpha q Pathway
0.0 0.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 3.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 2.9 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 0.9 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.1 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 2.0 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.7 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.3 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 3.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.4 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle