Motif ID: Foxo4

Z-value: 0.998


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_101254574-0.077.9e-01Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Showing 1 to 20 of 84 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_5796924 5.331 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr2_-_175338197 1.688 ENSMUST00000121393.2
 Gm4631
predicted gene 4631
chr2_-_175931051 1.343 ENSMUST00000108949.2
ENSMUST00000109018.2
 Gm8898

predicted gene 8898

chr2_-_175141999 1.289 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
 Gm14399


predicted gene 14399


chr7_-_4778141 1.176 ENSMUST00000094892.5
 Il11
interleukin 11
chr17_-_23745829 1.157 ENSMUST00000046525.8
 Kremen2
kringle containing transmembrane protein 2
chr2_+_176521056 1.124 ENSMUST00000108997.2
ENSMUST00000178443.1
 Gm14431

predicted gene 14431

chr10_-_53638269 1.103 ENSMUST00000164393.1
 Fam184a
family with sequence similarity 184, member A
chr2_+_176226569 1.096 ENSMUST00000099009.2
ENSMUST00000136719.1
 2210418O10Rik

RIKEN cDNA 2210418O10 gene

chr2_-_176927809 1.046 ENSMUST00000099007.2
 Gm14296
predicted gene 14296
chr2_+_175372436 1.021 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
 Gm4723


predicted gene 4723


chr2_-_177957239 0.992 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
 Gm14326


predicted gene 14326


chr2_-_175703646 0.982 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
 Gm4245


predicted gene 4245


chr2_+_175469985 0.932 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
 Gm8923



predicted gene 8923



chr6_+_42286676 0.898 ENSMUST00000031894.6
 Clcn1
chloride channel 1
chr2_-_175206899 0.880 ENSMUST00000109055.1
ENSMUST00000099028.3
ENSMUST00000109056.1
ENSMUST00000109058.2
 Gm14391



predicted gene 14391



chr8_+_26119361 0.871 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
 Rnf170



ring finger protein 170



chr2_+_176670522 0.870 ENSMUST00000121956.1
ENSMUST00000108985.2
 Gm14306

predicted gene 14306

chr11_-_77078404 0.816 ENSMUST00000102494.1
 Ccdc55
coiled-coil domain containing 55
chr2_+_178023284 0.790 ENSMUST00000108925.3
ENSMUST00000108926.2
 Etohi1

ethanol induced 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 5.3 GO:0035063 nuclear speck organization(GO:0035063)
0.2 1.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 1.2 GO:0046888 negative regulation of hormone secretion(GO:0046888)
0.0 1.2 GO:0030279 negative regulation of ossification(GO:0030279)
0.1 0.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.7 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 0.6 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.0 0.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.5 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.5 GO:0014029 neural crest formation(GO:0014029)
0.0 0.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.5 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.4 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.0 0.4 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.3 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 0.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.3 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.0 0.3 GO:0071420 cellular response to histamine(GO:0071420)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0016607 nuclear speck(GO:0016607)
0.1 2.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.8 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.6 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.5 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 0.3 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.3 GO:0005125 cytokine activity(GO:0005125)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.7 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.2 0.6 GO:0030172 troponin C binding(GO:0030172)
0.1 0.6 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.1 0.5 GO:0097643 amylin receptor activity(GO:0097643)
0.0 0.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.4 GO:0044548 S100 protein binding(GO:0044548)
0.1 0.3 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 0.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.1 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.3 PID_S1P_S1P1_PATHWAY S1P1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 0.6 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines