Motif ID: Tcf21_Msc
Z-value: 1.156
Transcription factors associated with Tcf21_Msc:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Msc | ENSMUSG00000025930.5 | Msc |
| Tcf21 | ENSMUSG00000045680.7 | Tcf21 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 178 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.0 | 2.3 | GO:0051592 | response to calcium ion(GO:0051592) |
| 0.2 | 2.2 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.1 | 2.0 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.5 | 1.5 | GO:0006601 | creatine biosynthetic process(GO:0006601) |
| 0.2 | 1.4 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.1 | 1.4 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.1 | 1.4 | GO:0006721 | terpenoid metabolic process(GO:0006721) |
| 0.3 | 1.2 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.2 | 1.2 | GO:0003105 | negative regulation of glomerular filtration(GO:0003105) positive regulation of NAD(P)H oxidase activity(GO:0033864) positive regulation of toll-like receptor 2 signaling pathway(GO:0034137) |
| 0.1 | 1.1 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.0 | 1.1 | GO:0048709 | oligodendrocyte differentiation(GO:0048709) |
| 0.1 | 1.0 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.1 | 1.0 | GO:0090205 | positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205) |
| 0.0 | 1.0 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 1.0 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.3 | 0.9 | GO:0018094 | protein polyglycylation(GO:0018094) |
| 0.1 | 0.9 | GO:0032695 | negative regulation of interleukin-12 production(GO:0032695) |
| 0.1 | 0.9 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 0.9 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 63 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 2.2 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 1.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 1.3 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.2 | 1.2 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 1.0 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 1.0 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 1.0 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.2 | 0.8 | GO:0097574 | lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795) |
| 0.2 | 0.8 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.2 | 0.7 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.0 | 0.7 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.7 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 0.6 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 0.6 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.6 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.0 | 0.5 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.0 | 0.5 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 0.5 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 103 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.3 | 2.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.1 | 1.6 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
| 0.0 | 1.6 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.1 | 1.5 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.1 | 1.4 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.3 | 1.2 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 1.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 1.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 1.0 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 1.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.3 | 0.9 | GO:0070736 | protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) |
| 0.2 | 0.9 | GO:0019841 | retinal binding(GO:0016918) retinol binding(GO:0019841) |
| 0.1 | 0.9 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 0.9 | GO:1901505 | carbohydrate derivative transporter activity(GO:1901505) |
| 0.2 | 0.8 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.1 | 0.8 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
| 0.2 | 0.7 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 0.2 | 0.7 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.1 | 0.7 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 27 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.6 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.0 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.9 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.8 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 0.8 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.7 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.0 | 0.7 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.6 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.6 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.5 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.5 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.5 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.5 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.4 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.3 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.3 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 27 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 1.8 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.6 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 1.2 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 1.2 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 1.2 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 1.0 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 1.0 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 1.0 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 0.7 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.6 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.6 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.6 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.4 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.4 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.4 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 0.3 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 0.3 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.0 | 0.3 | REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
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