ISMARA results: Hey2

Motif ID: Hey2

Z-value: 0.478

Transcription factors associated with Hey2:

Gene Symbol	Entrez ID	Gene Name
Hey2	ENSMUSG00000019789.8	Hey2

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Hey2	mm10_v2_chr10_-_30842765_30842801	0.31	2.1e-01	Click!

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Showing 1 to 20 of 180 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr8_+_105518736	1.798	ENSMUST00000034363.5	Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2
chr7_-_66427469	1.242	ENSMUST00000015278.7	Aldh1a3	aldehyde dehydrogenase family 1, subfamily A3
chr8_+_87473116	1.165	ENSMUST00000182650.1 ENSMUST00000182758.1 ENSMUST00000181898.1	Gm2694	predicted gene 2694
chr4_-_107683576	1.094	ENSMUST00000131776.1	Dmrtb1	DMRT-like family B with proline-rich C-terminal, 1
chr6_+_47244359	0.704	ENSMUST00000060839.6	Cntnap2	contactin associated protein-like 2
chr8_+_87472805	0.667	ENSMUST00000180700.2 ENSMUST00000182174.1 ENSMUST00000181159.1	Gm2694	predicted gene 2694
chr4_+_116877376	0.651	ENSMUST00000044823.3	Zswim5	zinc finger SWIM-type containing 5
chr8_+_87472838	0.651	ENSMUST00000180806.2	Gm2694	predicted gene 2694
chr1_+_72824482	0.651	ENSMUST00000047328.4	Igfbp2	insulin-like growth factor binding protein 2
chr1_+_87264345	0.625	ENSMUST00000118687.1 ENSMUST00000027472.6	Efhd1	EF hand domain containing 1
chr7_+_27486910	0.600	ENSMUST00000008528.7	Sertad1	SERTA domain containing 1
chr8_+_119446719	0.588	ENSMUST00000098363.3	Necab2	N-terminal EF-hand calcium binding protein 2
chr4_-_117133953	0.572	ENSMUST00000076859.5	Plk3	polo-like kinase 3
chr1_-_127677923	0.471	ENSMUST00000160616.1	Tmem163	transmembrane protein 163
chr12_+_117843489	0.435	ENSMUST00000021592.9	Cdca7l	cell division cycle associated 7 like
chr13_-_49652714	0.434	ENSMUST00000021818.7	Cenpp	centromere protein P
chr4_+_46450892	0.424	ENSMUST00000102926.4	Anp32b	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr14_-_67933512	0.421	ENSMUST00000039135.4	Dock5	dedicator of cytokinesis 5
chrX_-_52165252	0.405	ENSMUST00000033450.2	Gpc4	glypican 4
chr14_-_31019055	0.374	ENSMUST00000037739.6	Gnl3	guanine nucleotide binding protein-like 3 (nucleolar)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 56 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.8	GO:0001977	renal system process involved in regulation of blood volume(GO:0001977)
0.4	1.2	GO:0060166	olfactory pit development(GO:0060166)
0.0	0.8	GO:0015985	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2	0.7	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.1	0.7	GO:0055064	carbon dioxide transport(GO:0015670) chloride ion homeostasis(GO:0055064)
0.0	0.7	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2	0.6	GO:0060167	regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
0.1	0.6	GO:0090166	Golgi disassembly(GO:0090166) regulation of chaperone-mediated autophagy(GO:1904714)
0.1	0.4	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1	0.4	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0	0.4	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.4	GO:0043486	histone exchange(GO:0043486)
0.0	0.4	GO:1904816	positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.1	0.3	GO:0045819	plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1	0.3	GO:0046552	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) retinal rod cell differentiation(GO:0060221)
0.1	0.3	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0	0.3	GO:0032782	bile acid secretion(GO:0032782)
0.0	0.3	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.3	GO:0006228	UTP biosynthetic process(GO:0006228)
0.0	0.3	GO:0070307	lens fiber cell development(GO:0070307)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 25 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:0045261	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.7	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.5	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.4	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.4	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.0	0.3	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.3	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.3	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.3	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.3	GO:0005652	nuclear lamina(GO:0005652)
0.1	0.2	GO:0034457	Mpp10 complex(GO:0034457)
0.1	0.2	GO:0001405	presequence translocase-associated import motor(GO:0001405)
0.1	0.2	GO:0044194	cytolytic granule(GO:0044194)
0.0	0.2	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.0	0.2	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.2	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.2	GO:0002178	palmitoyltransferase complex(GO:0002178)
0.0	0.2	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.2	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	0.2	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 34 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.8	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.3	1.2	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1	1.1	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1	0.7	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.1	0.7	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.1	0.6	GO:0031687	A2A adenosine receptor binding(GO:0031687)
0.0	0.5	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.4	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.4	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.4	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.1	0.3	GO:0000402	open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1	0.3	GO:0035402	histone kinase activity (H3-T11 specific)(GO:0035402)
0.1	0.3	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0	0.3	GO:0004673	protein histidine kinase activity(GO:0004673)
0.0	0.3	GO:0005212	structural constituent of eye lens(GO:0005212)
0.1	0.2	GO:0046899	nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1	0.2	GO:0015403	thiamine uptake transmembrane transporter activity(GO:0015403)
0.0	0.2	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.2	GO:0070320	inward rectifier potassium channel inhibitor activity(GO:0070320)
0.0	0.2	GO:0017050	sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)

Gene overrepresentation in C2:CP category:

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Showing 1 to 2 of 2 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	PID_LPA4_PATHWAY	LPA4-mediated signaling events
0.0	0.3	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 12 of 12 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.7	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.6	REACTOME_METABOLISM_OF_NON_CODING_RNA	Genes involved in Metabolism of non-coding RNA
0.0	0.4	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.4	REACTOME_HS_GAG_DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.3	REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.3	REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.3	REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.2	REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.2	REACTOME_INTRINSIC_PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.1	REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.1	REACTOME_GAP_JUNCTION_ASSEMBLY	Genes involved in Gap junction assembly