Motif ID: Mnx1_Lhx6_Lmx1a

Z-value: 1.099

Transcription factors associated with Mnx1_Lhx6_Lmx1a:

Gene SymbolEntrez IDGene Name
Lhx6 ENSMUSG00000026890.13 Lhx6
Lmx1a ENSMUSG00000026686.8 Lmx1a
Mnx1 ENSMUSG00000001566.8 Mnx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lmx1amm10_v2_chr1_+_167689108_1676892390.672.2e-03Click!
Lhx6mm10_v2_chr2_-_36105271_36105434-0.617.5e-03Click!


Activity profile for motif Mnx1_Lhx6_Lmx1a.

activity profile for motif Mnx1_Lhx6_Lmx1a


Sorted Z-values histogram for motif Mnx1_Lhx6_Lmx1a

Sorted Z-values for motif Mnx1_Lhx6_Lmx1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mnx1_Lhx6_Lmx1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_61902669 8.246 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr5_+_139543889 7.988 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_+_20737306 7.696 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr6_-_147264124 6.215 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr14_-_48665098 5.508 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr3_+_125404292 4.038 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_55782500 4.016 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr19_+_44493472 3.959 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr14_-_118052235 3.912 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr3_+_125404072 3.866 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr13_-_102906046 3.587 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102905740 3.532 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr9_+_119063429 3.239 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr7_-_49636847 3.040 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr2_-_168767136 2.976 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr1_-_172027269 2.948 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr3_-_88410295 2.811 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr13_-_53473074 2.483 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr2_-_168767029 2.448 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr4_-_97778042 2.438 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 8.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.4 8.2 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
1.9 7.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.0 6.2 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.3 5.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.6 4.9 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.3 4.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.0 3.9 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.7 3.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.7 3.0 GO:0015889 cobalamin transport(GO:0015889)
0.2 3.0 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 2.8 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.1 2.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.8 2.5 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.1 2.4 GO:0051693 actin filament capping(GO:0051693)
0.2 2.3 GO:0060539 diaphragm development(GO:0060539)
0.1 2.3 GO:0033194 response to hydroperoxide(GO:0033194)
0.7 2.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 2.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 2.2 GO:0030497 fatty acid elongation(GO:0030497)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.5 GO:0005615 extracellular space(GO:0005615)
0.2 8.2 GO:0002102 podosome(GO:0002102)
0.0 6.6 GO:0000792 heterochromatin(GO:0000792)
0.0 5.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.2 4.9 GO:0060187 cell pole(GO:0060187)
0.1 4.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 4.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 3.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 3.0 GO:0043296 apical junction complex(GO:0043296)
0.5 2.8 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 2.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 2.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 2.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 2.1 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.9 GO:0032590 dendrite membrane(GO:0032590)
0.4 1.7 GO:0008623 CHRAC(GO:0008623)
0.1 1.6 GO:0070469 respiratory chain(GO:0070469)
0.1 1.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.5 GO:0000776 kinetochore(GO:0000776)
0.1 1.3 GO:0005915 zonula adherens(GO:0005915)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.9 GO:0008134 transcription factor binding(GO:0008134)
0.1 8.5 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
1.1 7.9 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 6.6 GO:0051015 actin filament binding(GO:0051015)
0.4 6.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 5.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 5.3 GO:0005109 frizzled binding(GO:0005109)
0.0 4.6 GO:0003779 actin binding(GO:0003779)
0.0 4.5 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 4.4 GO:0000287 magnesium ion binding(GO:0000287)
0.3 3.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 3.3 GO:0008483 transaminase activity(GO:0008483)
0.8 3.0 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.4 3.0 GO:0031419 cobalamin binding(GO:0031419)
0.2 2.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 2.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 2.6 GO:0070410 co-SMAD binding(GO:0070410)
0.1 2.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.7 2.2 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 5.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.4 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.1 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.4 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 1.0 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.9 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.7 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 7.9 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 5.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 4.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 4.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.6 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 1.2 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 1.0 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 1.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.0 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.0 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.9 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.9 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production