Motif ID: Bhlhe40

Z-value: 0.607


Transcription factors associated with Bhlhe40:

Gene SymbolEntrez IDGene Name
Bhlhe40 ENSMUSG00000030103.5 Bhlhe40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe40mm10_v2_chr6_+_108660772_1086608740.542.0e-02Click!


Activity profile for motif Bhlhe40.

activity profile for motif Bhlhe40


Sorted Z-values histogram for motif Bhlhe40

Sorted Z-values for motif Bhlhe40



Network of associatons between targets according to the STRING database.



First level regulatory network of Bhlhe40

PNG image of the network

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Top targets:


Showing 1 to 20 of 83 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_148039097 2.459 ENSMUST00000141283.1
Mthfr
5,10-methylenetetrahydrofolate reductase
chr4_-_148038769 1.936 ENSMUST00000030879.5
ENSMUST00000137724.1
Clcn6

chloride channel 6

chr4_+_148039035 1.918 ENSMUST00000097788.4
Mthfr
5,10-methylenetetrahydrofolate reductase
chr7_+_121707189 1.604 ENSMUST00000065310.2
1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr2_+_30286406 1.176 ENSMUST00000138666.1
ENSMUST00000113634.2
Nup188

nucleoporin 188

chr16_-_44139630 1.115 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr16_-_44139003 1.105 ENSMUST00000124102.1
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr5_-_123572976 1.035 ENSMUST00000031388.8
Vps33a
vacuolar protein sorting 33A (yeast)
chr5_+_65199691 0.953 ENSMUST00000041892.8
Wdr19
WD repeat domain 19
chr12_-_79296266 0.933 ENSMUST00000021547.6
Zfyve26
zinc finger, FYVE domain containing 26
chr12_-_3426700 0.845 ENSMUST00000180149.1
1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr2_+_30286383 0.801 ENSMUST00000064447.5
Nup188
nucleoporin 188
chr8_+_85036906 0.714 ENSMUST00000093360.4
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr11_-_75454656 0.667 ENSMUST00000173320.1
Wdr81
WD repeat domain 81
chr7_-_35802968 0.657 ENSMUST00000061586.4
Zfp507
zinc finger protein 507
chr8_+_85037151 0.654 ENSMUST00000166592.1
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr7_+_35802593 0.652 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr1_-_152766323 0.620 ENSMUST00000111857.1
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr16_+_8830093 0.614 ENSMUST00000023150.5
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr1_-_152766281 0.561 ENSMUST00000111859.1
ENSMUST00000148865.1
Rgl1

ral guanine nucleotide dissociation stimulator,-like 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 4.4 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 2.6 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 2.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.4 2.0 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.1 1.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 1.0 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) myotome development(GO:0061055)
0.1 1.0 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.0 0.7 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.7 GO:0097178 ruffle assembly(GO:0097178)
0.1 0.5 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 0.5 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.5 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.3 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 0.3 GO:1903012 positive regulation of bone development(GO:1903012)
0.0 0.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.3 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.2 GO:0019482 beta-alanine metabolic process(GO:0019482)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 2.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 2.0 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 1.3 GO:0033263 CORVET complex(GO:0033263)
0.1 1.0 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.7 GO:0044306 neuron projection terminus(GO:0044306)
0.1 0.3 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 4.4 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 2.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 2.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 2.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 1.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.7 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.2 0.5 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.4 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.3 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0004348 glucosylceramidase activity(GO:0004348)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 2.0 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.4 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.3 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.0 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling