Motif ID: Nfia

Z-value: 1.656


Transcription factors associated with Nfia:

Gene SymbolEntrez IDGene Name
Nfia ENSMUSG00000028565.12 Nfia

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfiamm10_v2_chr4_+_97772734_97772848-0.292.4e-01Click!


Activity profile for motif Nfia.

activity profile for motif Nfia


Sorted Z-values histogram for motif Nfia

Sorted Z-values for motif Nfia



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfia

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 7.145 ENSMUST00000075312.3
 Ttr
transthyretin
chr10_+_4611971 4.428 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr4_-_154097105 4.186 ENSMUST00000105643.1
ENSMUST00000133533.1
ENSMUST00000097762.4
 Trp73


transformation related protein 73


chr2_+_164562579 3.683 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr3_-_8667033 3.614 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr3_+_94377432 3.288 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma
chr11_+_78324200 3.104 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr4_+_109978004 3.028 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr14_-_118052235 2.996 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr11_-_89302545 2.907 ENSMUST00000061728.3
 Nog
noggin
chr3_+_94377505 2.688 ENSMUST00000098877.2
 Rorc
RAR-related orphan receptor gamma
chr6_+_17306335 2.581 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr19_+_25610533 2.365 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr14_-_122465677 2.291 ENSMUST00000039118.6
 Zic5
zinc finger protein of the cerebellum 5
chr7_+_130936172 2.187 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr3_+_94372794 2.098 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr12_-_91746020 2.071 ENSMUST00000166967.1
 Ston2
stonin 2
chr6_-_67037399 2.032 ENSMUST00000043098.6
 Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr12_+_110279228 2.032 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr16_+_30065333 1.918 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 368 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 8.1 GO:0072615 interleukin-17 secretion(GO:0072615)
1.6 7.9 GO:0070327 thyroid hormone transport(GO:0070327)
1.2 7.3 GO:0072049 comma-shaped body morphogenesis(GO:0072049)
0.4 5.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
1.1 4.4 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
1.1 4.3 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.8 3.9 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.7 3.4 GO:0072138 mesenchymal cell proliferation involved in ureteric bud development(GO:0072138)
0.4 3.1 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.3 3.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 3.0 GO:0006570 tyrosine metabolic process(GO:0006570)
0.4 3.0 GO:0048251 elastic fiber assembly(GO:0048251)
0.7 2.9 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.2 2.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 2.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 2.5 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.2 2.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 2.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.4 2.2 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.2 2.2 GO:0090527 actin filament reorganization(GO:0090527)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.7 GO:0005615 extracellular space(GO:0005615)
0.0 9.8 GO:0016604 nuclear body(GO:0016604)
0.6 4.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 4.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 3.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 3.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 3.2 GO:0005884 actin filament(GO:0005884)
0.1 2.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.6 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 2.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 2.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 2.3 GO:0000786 nucleosome(GO:0000786)
0.0 2.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.8 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 1.8 GO:0000793 condensed chromosome(GO:0000793)
0.4 1.7 GO:0032280 symmetric synapse(GO:0032280)
0.0 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.6 GO:0000145 exocyst(GO:0000145)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 8.1 GO:0008142 oxysterol binding(GO:0008142)
0.9 7.9 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 5.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 4.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.4 4.6 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
1.5 4.4 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.9 4.3 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.8 3.9 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
1.2 3.6 GO:0035939 microsatellite binding(GO:0035939)
0.3 3.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 3.3 GO:0019955 cytokine binding(GO:0019955)
0.5 3.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 2.5 GO:0042169 SH2 domain binding(GO:0042169)
0.3 2.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.3 2.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 2.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 2.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 2.0 GO:0030274 LIM domain binding(GO:0030274)
0.0 1.9 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 6.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 5.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.9 PID_BMP_PATHWAY BMP receptor signaling
0.1 4.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 4.3 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 3.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 2.3 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 2.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 1.7 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.6 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 1.5 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 1.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.5 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.4 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.3 PID_NOTCH_PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 9.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.2 5.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.2 5.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 4.8 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 4.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 4.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 4.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 3.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 3.1 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 2.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 2.4 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 2.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 2.0 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.1 1.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 1.8 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.7 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 1.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.4 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation