Motif ID: Etv1_Etv5_Gabpa

Z-value: 1.878

Transcription factors associated with Etv1_Etv5_Gabpa:

Gene SymbolEntrez IDGene Name
Etv1 ENSMUSG00000004151.10 Etv1
Etv5 ENSMUSG00000013089.9 Etv5
Gabpa ENSMUSG00000008976.10 Gabpa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv5mm10_v2_chr16_-_22439719_22439733-0.681.8e-03Click!
Gabpamm10_v2_chr16_+_84834901_84834941-0.653.8e-03Click!
Etv1mm10_v2_chr12_+_38780284_38780349-0.503.5e-02Click!


Activity profile for motif Etv1_Etv5_Gabpa.

activity profile for motif Etv1_Etv5_Gabpa


Sorted Z-values histogram for motif Etv1_Etv5_Gabpa

Sorted Z-values for motif Etv1_Etv5_Gabpa



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv1_Etv5_Gabpa

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_94653964 5.917 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr2_-_130179310 5.626 ENSMUST00000103199.4
 Snrpb
small nuclear ribonucleoprotein B
chr6_-_56704673 5.220 ENSMUST00000170382.2
 Lsm5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr7_-_126792469 5.168 ENSMUST00000032936.6
 Ppp4c
protein phosphatase 4, catalytic subunit
chr16_-_22161450 4.860 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr7_-_127042420 4.853 ENSMUST00000032915.6
 Kif22
kinesin family member 22
chr3_+_87930256 4.686 ENSMUST00000055984.6
 Isg20l2
interferon stimulated exonuclease gene 20-like 2
chr2_+_5845243 4.620 ENSMUST00000127116.1
 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr4_-_45320580 4.432 ENSMUST00000030003.3
 Exosc3
exosome component 3
chr2_+_74825802 4.348 ENSMUST00000028511.7
 Mtx2
metaxin 2
chr16_-_18811972 4.329 ENSMUST00000000028.7
ENSMUST00000115585.1
 Cdc45

cell division cycle 45

chr4_+_124850679 4.176 ENSMUST00000102628.4
 Yrdc
yrdC domain containing (E.coli)
chr5_+_99979061 4.133 ENSMUST00000046721.1
 4930524J08Rik
RIKEN cDNA 4930524J08 gene
chr2_+_5845017 4.037 ENSMUST00000026927.3
ENSMUST00000179748.1
 Nudt5

nudix (nucleoside diphosphate linked moiety X)-type motif 5

chr5_+_140331860 4.024 ENSMUST00000071881.3
ENSMUST00000050205.5
ENSMUST00000110827.1
 Nudt1


nudix (nucleoside diphosphate linked moiety X)-type motif 1


chr19_-_40271506 3.952 ENSMUST00000068439.6
 Pdlim1
PDZ and LIM domain 1 (elfin)
chr4_+_118409331 3.887 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
 Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)





chr2_+_118814237 3.830 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr11_-_69921057 3.814 ENSMUST00000108609.1
ENSMUST00000108608.1
ENSMUST00000164359.1
 Eif5a


eukaryotic translation initiation factor 5A


chrX_+_105079761 3.758 ENSMUST00000119477.1
 Pbdc1
polysaccharide biosynthesis domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 652 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 30.4 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.7 25.2 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 21.2 GO:0006413 translational initiation(GO:0006413)
0.2 17.5 GO:0051028 mRNA transport(GO:0051028)
0.3 14.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.3 13.7 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.2 13.3 GO:0032543 mitochondrial translation(GO:0032543)
0.6 12.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.6 11.6 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 10.9 GO:0042254 ribosome biogenesis(GO:0042254)
2.6 10.6 GO:0019323 pentose catabolic process(GO:0019323)
0.8 10.2 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.3 9.5 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.2 9.3 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.6 9.0 GO:0043248 proteasome assembly(GO:0043248)
0.4 8.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.5 8.6 GO:0045116 protein neddylation(GO:0045116)
0.3 8.5 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.9 8.4 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
1.8 7.3 GO:0030576 Cajal body organization(GO:0030576)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 319 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 39.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.6 29.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 27.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 24.5 GO:0070062 extracellular exosome(GO:0070062)
0.0 23.5 GO:0005730 nucleolus(GO:0005730)
0.3 15.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
1.4 13.6 GO:0031595 nuclear proteasome complex(GO:0031595)
0.6 11.6 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 11.2 GO:0001726 ruffle(GO:0001726)
0.3 10.5 GO:0035371 microtubule plus-end(GO:0035371)
1.1 10.3 GO:0005687 U4 snRNP(GO:0005687)
0.2 10.0 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.1 9.4 GO:0005681 spliceosomal complex(GO:0005681)
0.4 8.7 GO:0005839 proteasome core complex(GO:0005839)
0.3 8.5 GO:0032040 small-subunit processome(GO:0032040)
0.9 8.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.4 8.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.6 8.3 GO:0031011 Ino80 complex(GO:0031011)
0.3 8.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
1.6 7.8 GO:0005683 U7 snRNP(GO:0005683)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 414 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 83.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 26.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.8 13.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.4 11.0 GO:0017025 TBP-class protein binding(GO:0017025)
1.4 10.0 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.2 9.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 9.9 GO:0051087 chaperone binding(GO:0051087)
2.9 8.7 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
1.2 8.7 GO:1990446 U1 snRNP binding(GO:1990446)
0.6 8.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 8.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 8.7 GO:0002039 p53 binding(GO:0002039)
0.8 8.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
2.8 8.3 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.4 8.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 7.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
2.4 7.3 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.0 7.2 GO:0032561 guanyl ribonucleotide binding(GO:0032561)
0.4 6.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 6.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.4 18.9 PID_ATR_PATHWAY ATR signaling pathway
0.4 17.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 8.3 PID_MYC_PATHWAY C-MYC pathway
0.2 8.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 7.6 PID_E2F_PATHWAY E2F transcription factor network
0.2 5.7 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 5.4 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.3 4.7 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 4.6 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 4.3 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 3.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.7 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 3.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.1 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.1 3.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 2.5 PID_BARD1_PATHWAY BARD1 signaling events
0.1 2.5 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 39.0 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.7 37.6 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.5 35.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 22.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 21.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.3 19.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
1.5 18.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.5 12.9 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.2 10.2 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.6 10.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.4 9.5 REACTOME_KINESINS Genes involved in Kinesins
0.5 9.1 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.3 8.6 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 8.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.4 7.4 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.3 7.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 7.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3 7.3 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.3 7.0 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.2 6.6 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC