Motif ID: Fosb

Z-value: 0.327


Transcription factors associated with Fosb:

Gene SymbolEntrez IDGene Name
Fosb ENSMUSG00000003545.2 Fosb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosbmm10_v2_chr7_-_19310035_19310050-0.419.5e-02Click!


Activity profile for motif Fosb.

activity profile for motif Fosb


Sorted Z-values histogram for motif Fosb

Sorted Z-values for motif Fosb



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosb

PNG image of the network

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Top targets:


Showing 1 to 20 of 70 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_80000292 1.069 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr2_+_118663235 0.871 ENSMUST00000099557.3
 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr14_+_27622433 0.740 ENSMUST00000090302.5
 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr16_+_17561885 0.602 ENSMUST00000171002.1
ENSMUST00000023441.4
 P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr3_+_55461758 0.594 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr6_-_124769548 0.559 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr6_+_86849488 0.541 ENSMUST00000089519.6
ENSMUST00000113668.1
 Aak1

AP2 associated kinase 1

chr9_+_104566677 0.506 ENSMUST00000157006.1
 Cpne4
copine IV
chr13_-_54611332 0.453 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr3_+_123267445 0.444 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr2_-_45110241 0.441 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr13_-_113663670 0.440 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr13_-_54611274 0.421 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr2_-_151632471 0.394 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr2_-_29253001 0.390 ENSMUST00000071201.4
 Ntng2
netrin G2
chr10_-_64090265 0.370 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr2_+_156475844 0.363 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr10_-_64090241 0.360 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr11_-_100397740 0.359 ENSMUST00000001592.8
ENSMUST00000107403.1
 Jup

junction plakoglobin

chr18_-_31317043 0.350 ENSMUST00000139924.1
ENSMUST00000153060.1
 Rit2

Ras-like without CAAX 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.9 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 0.7 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 0.6 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.0 0.6 GO:0033198 response to ATP(GO:0033198)
0.0 0.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.5 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.1 0.4 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.4 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.1 0.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.3 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.0 0.3 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.2 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.2 GO:0048840 otolith development(GO:0048840)
0.0 0.2 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.1 GO:0042581 specific granule(GO:0042581)
0.1 0.9 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 0.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.5 GO:0071439 clathrin complex(GO:0071439)
0.1 0.5 GO:0005638 lamin filament(GO:0005638)
0.0 0.4 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.3 GO:0097447 dendritic tree(GO:0097447)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0044753 amphisome(GO:0044753)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.9 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 0.6 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.6 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.5 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 0.1 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.0 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.9 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.2 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix