Motif ID: Klf6_Patz1

Z-value: 1.212

Transcription factors associated with Klf6_Patz1:

Gene SymbolEntrez IDGene Name
Klf6 ENSMUSG00000000078.6 Klf6
Patz1 ENSMUSG00000020453.11 Patz1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf6mm10_v2_chr13_+_5861489_58615010.381.2e-01Click!
Patz1mm10_v2_chr11_+_3289168_3289281-0.312.2e-01Click!


Activity profile for motif Klf6_Patz1.

activity profile for motif Klf6_Patz1


Sorted Z-values histogram for motif Klf6_Patz1

Sorted Z-values for motif Klf6_Patz1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf6_Patz1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_44310213 2.639 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chrX_+_13071470 2.622 ENSMUST00000169594.2
 Usp9x
ubiquitin specific peptidase 9, X chromosome
chr7_+_25268387 2.200 ENSMUST00000169392.1
 Cic
capicua homolog (Drosophila)
chr2_-_161109017 2.117 ENSMUST00000039782.7
ENSMUST00000134178.1
 Chd6

chromodomain helicase DNA binding protein 6

chr1_-_161034794 1.928 ENSMUST00000177003.1
ENSMUST00000162226.2
ENSMUST00000159250.2
 Zbtb37


zinc finger and BTB domain containing 37


chr5_+_37028329 1.898 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr8_+_107293500 1.886 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
 Nfat5


nuclear factor of activated T cells 5


chr5_-_25498702 1.881 ENSMUST00000173073.1
ENSMUST00000045291.7
 Kmt2c

lysine (K)-specific methyltransferase 2C

chr16_+_44173271 1.853 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr15_+_99295087 1.828 ENSMUST00000128352.1
ENSMUST00000145482.1
 Prpf40b

PRP40 pre-mRNA processing factor 40 homolog B (yeast)

chr4_-_22488296 1.757 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr2_-_24763047 1.694 ENSMUST00000100348.3
ENSMUST00000041342.5
ENSMUST00000114447.1
ENSMUST00000102939.2
ENSMUST00000070864.7
 Cacna1b




calcium channel, voltage-dependent, N type, alpha 1B subunit




chr10_-_127620960 1.692 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr2_+_76406529 1.690 ENSMUST00000111929.1
ENSMUST00000077972.4
ENSMUST00000111930.2
 Osbpl6


oxysterol binding protein-like 6


chrX_-_160994665 1.642 ENSMUST00000087104.4
 Cdkl5
cyclin-dependent kinase-like 5
chr6_-_119848059 1.639 ENSMUST00000184864.1
 Erc1
ELKS/RAB6-interacting/CAST family member 1
chr8_+_107293463 1.592 ENSMUST00000169453.1
 Nfat5
nuclear factor of activated T cells 5
chr6_-_119848093 1.587 ENSMUST00000079582.4
 Erc1
ELKS/RAB6-interacting/CAST family member 1
chr7_+_28180272 1.547 ENSMUST00000173223.1
 Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr14_-_20794009 1.525 ENSMUST00000100837.3
ENSMUST00000080440.6
ENSMUST00000071816.6
 Camk2g


calcium/calmodulin-dependent protein kinase II gamma



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 627 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 4.2 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.9 3.8 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.3 3.3 GO:0046959 habituation(GO:0046959)
1.0 3.1 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.3 3.0 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 3.0 GO:0007520 myoblast fusion(GO:0007520)
0.3 2.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 2.7 GO:2000821 regulation of grooming behavior(GO:2000821)
0.5 2.5 GO:0051684 maintenance of Golgi location(GO:0051684)
0.2 2.4 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.5 2.2 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.1 2.2 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.1 2.2 GO:0055119 relaxation of cardiac muscle(GO:0055119)
0.0 2.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.5 2.0 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.4 2.0 GO:0060178 regulation of exocyst localization(GO:0060178)
0.3 2.0 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 2.0 GO:0035608 protein deglutamylation(GO:0035608)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 8.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 4.8 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.3 4.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 4.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 3.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 3.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 3.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 3.1 GO:0055037 recycling endosome(GO:0055037)
0.1 3.0 GO:0035371 microtubule plus-end(GO:0035371)
0.1 2.7 GO:0043194 axon initial segment(GO:0043194)
0.1 2.7 GO:0043034 costamere(GO:0043034)
0.1 2.7 GO:0090544 BAF-type complex(GO:0090544)
0.0 2.7 GO:0008021 synaptic vesicle(GO:0008021)
0.3 2.6 GO:0045298 tubulin complex(GO:0045298)
0.1 2.6 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 2.6 GO:0016605 PML body(GO:0016605)
0.1 2.5 GO:0032279 asymmetric synapse(GO:0032279)
0.1 2.4 GO:0032590 dendrite membrane(GO:0032590)
0.2 2.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 343 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.8 GO:0005096 GTPase activator activity(GO:0005096)
0.1 11.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 7.1 GO:0008017 microtubule binding(GO:0008017)
0.1 5.9 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 4.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.3 3.8 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.1 3.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 3.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 3.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 3.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 3.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 3.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.8 3.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 3.1 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.4 3.0 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 2.9 GO:0070412 R-SMAD binding(GO:0070412)
0.2 2.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 2.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 2.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 2.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 5.1 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 4.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 4.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 2.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 2.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 2.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 1.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.5 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 1.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.2 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.9 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 0.6 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 4.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 3.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 3.2 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.3 2.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.8 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 2.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 2.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.1 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.9 REACTOME_NEURONAL_SYSTEM Genes involved in Neuronal System
0.1 1.8 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 1.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.6 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.6 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 1.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.4 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions