Motif ID: Tead1

Z-value: 0.502


Transcription factors associated with Tead1:

Gene SymbolEntrez IDGene Name
Tead1 ENSMUSG00000055320.10 Tead1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tead1mm10_v2_chr7_+_112679314_1126793250.194.5e-01Click!


Activity profile for motif Tead1.

activity profile for motif Tead1


Sorted Z-values histogram for motif Tead1

Sorted Z-values for motif Tead1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tead1

PNG image of the network

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Top targets:


Showing 1 to 20 of 105 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_17306335 0.985 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr4_-_43558386 0.787 ENSMUST00000130353.1
 Tln1
talin 1
chr14_-_54577578 0.713 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr11_-_5381734 0.670 ENSMUST00000172492.1
 Znrf3
zinc and ring finger 3
chr19_-_4439388 0.658 ENSMUST00000117462.1
ENSMUST00000048197.3
 Rhod

ras homolog gene family, member D

chr15_+_6386598 0.628 ENSMUST00000080880.5
ENSMUST00000110664.2
ENSMUST00000110663.2
ENSMUST00000161812.1
ENSMUST00000160134.1
 Dab2




disabled 2, mitogen-responsive phosphoprotein




chr6_+_17306415 0.624 ENSMUST00000150901.1
 Cav1
caveolin 1, caveolae protein
chr17_-_35702297 0.616 ENSMUST00000135078.1
 Ddr1
discoidin domain receptor family, member 1
chr6_+_17307040 0.594 ENSMUST00000123439.1
 Cav1
caveolin 1, caveolae protein
chr2_+_20519776 0.585 ENSMUST00000114604.2
ENSMUST00000066509.3
 Etl4

enhancer trap locus 4

chr1_+_189728264 0.555 ENSMUST00000097442.2
 Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr9_-_8004585 0.532 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr17_-_35702040 0.517 ENSMUST00000166980.2
ENSMUST00000145900.1
 Ddr1

discoidin domain receptor family, member 1

chr17_-_35701937 0.516 ENSMUST00000155628.1
 Ddr1
discoidin domain receptor family, member 1
chr8_+_45628176 0.429 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr2_+_91457501 0.428 ENSMUST00000028689.3
 Lrp4
low density lipoprotein receptor-related protein 4
chr19_+_33822908 0.416 ENSMUST00000042061.6
 Gm5519
predicted pseudogene 5519
chr8_+_45627946 0.403 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr10_+_93641041 0.390 ENSMUST00000020204.4
 Ntn4
netrin 4
chr5_+_24426831 0.361 ENSMUST00000155598.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.2 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.1 1.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 1.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 1.0 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.9 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 0.8 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.1 0.7 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.7 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.1 0.6 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 0.6 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 0.5 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.4 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 0.4 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.3 GO:0060166 olfactory pit development(GO:0060166)
0.1 0.3 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.3 GO:0045023 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316)
0.0 0.3 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.0 0.3 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.1 0.2 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 0.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 0.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.0 0.4 GO:0016600 flotillin complex(GO:0016600)
0.0 0.2 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0016460 myosin II complex(GO:0016460)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.2 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.2 1.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.8 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.4 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.2 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.2 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0019966 interleukin-1 binding(GO:0019966)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.2 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.0 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.6 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 0.8 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.6 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.4 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.1 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.1 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport