Motif ID: Jun

Z-value: 0.598


Transcription factors associated with Jun:

Gene SymbolEntrez IDGene Name
Jun ENSMUSG00000052684.3 Jun

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Junmm10_v2_chr4_-_95052170_95052181-0.126.4e-01Click!


Activity profile for motif Jun.

activity profile for motif Jun


Sorted Z-values histogram for motif Jun

Sorted Z-values for motif Jun



Network of associatons between targets according to the STRING database.



First level regulatory network of Jun

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_7555053 1.205 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr3_-_88503187 1.012 ENSMUST00000120377.1
 Lmna
lamin A
chrX_-_167209149 0.772 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome
chr1_-_33907721 0.759 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr3_-_88503331 0.683 ENSMUST00000029699.6
 Lmna
lamin A
chr3_-_129969989 0.638 ENSMUST00000146340.1
 Ccdc109b
coiled-coil domain containing 109B
chr15_+_44196135 0.580 ENSMUST00000038856.6
ENSMUST00000110289.3
 Trhr

thyrotropin releasing hormone receptor

chr3_+_123267445 0.554 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr7_-_142899985 0.553 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr4_+_42158092 0.550 ENSMUST00000098122.2
 Gm13306
predicted gene 13306
chr2_+_165655237 0.529 ENSMUST00000063433.7
 Eya2
eyes absent 2 homolog (Drosophila)
chr13_-_90905321 0.524 ENSMUST00000109541.3
 Atp6ap1l
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr2_+_118663235 0.517 ENSMUST00000099557.3
 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr2_-_151632471 0.512 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr4_+_123183456 0.489 ENSMUST00000126995.1
 Hpcal4
hippocalcin-like 4
chr2_+_13573927 0.479 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chrX_+_164269371 0.461 ENSMUST00000145412.1
ENSMUST00000033749.7
 Pir

pirin

chr17_+_43953191 0.411 ENSMUST00000044792.4
 Rcan2
regulator of calcineurin 2
chr7_-_126799134 0.410 ENSMUST00000087566.4
 Aldoa
aldolase A, fructose-bisphosphate
chr7_+_127244511 0.408 ENSMUST00000052509.4
 Zfp771
zinc finger protein 771

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.7 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.4 1.2 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1 1.0 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.9 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 0.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 0.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.7 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 0.6 GO:0042414 epinephrine metabolic process(GO:0042414)
0.1 0.6 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.1 0.6 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.5 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.1 0.5 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.5 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.4 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 0.4 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.4 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 0.4 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.1 0.4 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.7 GO:0005638 lamin filament(GO:0005638)
0.0 0.8 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 0.6 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.5 GO:0045098 type III intermediate filament(GO:0045098)
0.1 0.4 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 0.4 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.4 GO:0031105 septin complex(GO:0031105)
0.0 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.4 GO:0002080 acrosomal membrane(GO:0002080)
0.1 0.3 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.3 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.1 0.2 GO:0098842 postsynaptic early endosome(GO:0098842)
0.1 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 0.7 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 0.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.6 GO:0035240 dopamine binding(GO:0035240)
0.0 0.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.5 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.4 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 0.4 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.4 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.4 GO:0043208 glycosphingolipid binding(GO:0043208)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.0 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.5 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 0.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.4 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.3 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.1 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 0.1 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.7 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 0.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 0.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.2 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.1 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling