Motif ID: Tgif1_Meis3

Z-value: 4.395

Transcription factors associated with Tgif1_Meis3:

Gene SymbolEntrez IDGene Name
Meis3 ENSMUSG00000041420.12 Meis3
Tgif1 ENSMUSG00000047407.11 Tgif1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif1mm10_v2_chr17_-_70851710_70851738-0.895.6e-07Click!
Meis3mm10_v2_chr7_+_16175085_161751390.672.2e-03Click!


Activity profile for motif Tgif1_Meis3.

activity profile for motif Tgif1_Meis3


Sorted Z-values histogram for motif Tgif1_Meis3

Sorted Z-values for motif Tgif1_Meis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif1_Meis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_49246131 29.764 ENSMUST00000064395.6
 Nav2
neuron navigator 2
chr15_-_66831625 26.659 ENSMUST00000164163.1
 Sla
src-like adaptor
chr4_-_64046925 22.595 ENSMUST00000107377.3
 Tnc
tenascin C
chr15_-_66801577 21.518 ENSMUST00000168589.1
 Sla
src-like adaptor
chr8_+_57455898 14.618 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr7_+_49246812 14.571 ENSMUST00000184945.1
 Nav2
neuron navigator 2
chr1_-_132542934 12.446 ENSMUST00000086521.4
 Cntn2
contactin 2
chr4_+_102254993 11.770 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr15_-_58076456 11.440 ENSMUST00000070143.6
ENSMUST00000110168.1
 Zhx1

zinc fingers and homeoboxes 1

chr8_+_70501116 11.288 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr3_+_26331150 10.418 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr15_+_18818895 10.015 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr7_+_112225856 9.252 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr1_+_159737510 9.183 ENSMUST00000111669.3
 Tnr
tenascin R
chr9_-_29963112 8.646 ENSMUST00000075069.4
 Ntm
neurotrimin
chr11_+_105589970 8.559 ENSMUST00000168598.1
ENSMUST00000100330.3
 Tanc2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr13_+_83504032 8.490 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr18_+_34247685 8.473 ENSMUST00000066133.6
 Apc
adenomatosis polyposis coli
chr1_-_134235420 8.393 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr6_-_53068562 8.206 ENSMUST00000074541.5
 Jazf1
JAZF zinc finger 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 574 entries
Log-likelihood per target Total log-likelihoodTermDescription
11.1 44.3 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
2.3 29.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.5 29.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
5.6 22.6 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
5.6 22.5 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.7 19.7 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.5 19.6 GO:0006376 mRNA splice site selection(GO:0006376)
2.3 16.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 13.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.2 13.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
4.1 12.4 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167)
0.6 12.2 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.3 12.1 GO:0034605 cellular response to heat(GO:0034605)
1.0 11.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
3.9 11.7 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
1.9 11.6 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.5 11.1 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 10.5 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 10.3 GO:0030032 lamellipodium assembly(GO:0030032)
3.4 10.2 GO:0007521 muscle cell fate determination(GO:0007521)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 65.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 57.7 GO:0016021 integral component of membrane(GO:0016021)
0.2 56.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 54.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 33.0 GO:0030427 site of polarized growth(GO:0030427)
0.9 30.8 GO:0090544 BAF-type complex(GO:0090544)
0.9 28.4 GO:0033268 node of Ranvier(GO:0033268)
1.0 25.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 22.7 GO:0043197 dendritic spine(GO:0043197)
0.1 21.3 GO:0001650 fibrillar center(GO:0001650)
0.1 16.5 GO:0030027 lamellipodium(GO:0030027)
1.1 15.0 GO:0016342 catenin complex(GO:0016342)
0.6 12.1 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.2 11.7 GO:0005801 cis-Golgi network(GO:0005801)
0.1 10.9 GO:0030424 axon(GO:0030424)
0.1 10.6 GO:0005802 trans-Golgi network(GO:0005802)
0.3 10.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.5 9.9 GO:0032279 asymmetric synapse(GO:0032279)
3.2 9.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
1.6 9.4 GO:0097443 sorting endosome(GO:0097443)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 350 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 50.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.1 43.7 GO:0030552 cAMP binding(GO:0030552)
0.3 39.1 GO:0008201 heparin binding(GO:0008201)
0.2 33.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 32.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 27.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
3.8 22.7 GO:0045545 syndecan binding(GO:0045545)
0.4 20.5 GO:0030507 spectrin binding(GO:0030507)
0.4 20.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.3 19.5 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.3 18.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
2.7 16.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.6 15.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.7 14.5 GO:0071949 FAD binding(GO:0071949)
2.9 14.4 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
1.0 12.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 11.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 11.3 GO:0017124 SH3 domain binding(GO:0017124)
1.6 11.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.5 10.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 34.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.4 25.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.9 24.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.4 21.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.4 21.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.3 12.7 SIG_CHEMOTAXIS Genes related to chemotaxis
0.3 12.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 11.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 11.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 10.4 PID_ARF_3PATHWAY Arf1 pathway
0.3 9.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.4 9.6 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 9.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.3 8.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 7.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 6.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 6.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.2 5.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.8 5.7 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.2 4.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 36.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 28.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.3 23.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.6 22.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.3 18.4 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.4 17.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.5 15.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.4 14.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 12.4 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.4 11.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 11.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 10.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.5 9.2 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.4 8.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3 8.9 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.6 8.5 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.3 7.9 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.4 7.8 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.5 7.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 7.7 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor