Motif ID: Lhx8

Z-value: 0.792


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.292.5e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 94 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_91090697 2.756 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 2.716 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr18_+_23415400 2.630 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr5_-_139129662 2.358 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr3_-_73056943 2.342 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr2_+_65620829 2.305 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr2_-_52558539 2.193 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr8_+_34054622 2.122 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr15_+_21111452 1.990 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr6_-_136173492 1.982 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr13_-_66851513 1.862 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr1_-_44218952 1.783 ENSMUST00000054801.3
 Mettl21e
methyltransferase like 21E
chrX_+_101640056 1.632 ENSMUST00000119299.1
ENSMUST00000044475.4
 Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr1_+_72284367 1.569 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr5_+_137553517 1.477 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr15_-_99820072 1.438 ENSMUST00000109024.2
 Lima1
LIM domain and actin binding 1
chr8_+_104831572 1.386 ENSMUST00000059449.6
 Ces2b
carboxyesterase 2B
chr13_-_62466709 1.204 ENSMUST00000076195.5
 Zfp935
zinc finger protein 935
chr6_+_15185203 1.133 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr19_+_11469353 1.095 ENSMUST00000165310.1
 Ms4a6c
membrane-spanning 4-domains, subfamily A, member 6C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.5 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.2 2.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 2.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 2.2 GO:0019227 neuronal action potential propagation(GO:0019227) detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) action potential propagation(GO:0098870)
0.5 2.0 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 2.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6 1.8 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.5 1.6 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 1.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.4 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.2 1.1 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.1 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.3 1.0 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 1.0 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 0.9 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.9 GO:0010107 potassium ion import(GO:0010107)
0.1 0.8 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.8 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 0.7 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.1 0.7 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 2.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 2.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 2.0 GO:0043083 synaptic cleft(GO:0043083)
0.1 2.0 GO:0042588 zymogen granule(GO:0042588)
0.1 1.5 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.0 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.9 GO:0005839 proteasome core complex(GO:0005839)
0.2 0.8 GO:0031673 H zone(GO:0031673)
0.0 0.7 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 0.6 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.6 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 3.4 GO:0030165 PDZ domain binding(GO:0030165)
0.2 2.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 2.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 2.0 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.3 1.8 GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043)
0.5 1.6 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 1.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.4 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.3 1.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.7 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.7 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 0.6 GO:0097643 amylin receptor activity(GO:0097643)
0.0 0.6 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 2.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 2.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.6 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly