Motif ID: Mafb

Z-value: 0.790


Transcription factors associated with Mafb:

Gene SymbolEntrez IDGene Name
Mafb ENSMUSG00000074622.3 Mafb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafbmm10_v2_chr2_-_160367057_1603670730.799.8e-05Click!


Activity profile for motif Mafb.

activity profile for motif Mafb


Sorted Z-values histogram for motif Mafb

Sorted Z-values for motif Mafb



Network of associatons between targets according to the STRING database.



First level regulatory network of Mafb

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_116307168 1.562 ENSMUST00000124281.1
 Exoc7
exocyst complex component 7
chr7_-_120202104 1.555 ENSMUST00000033198.5
 Crym
crystallin, mu
chr9_-_48911067 1.509 ENSMUST00000003826.7
 Htr3a
5-hydroxytryptamine (serotonin) receptor 3A
chr2_+_170731807 1.473 ENSMUST00000029075.4
 Dok5
docking protein 5
chr17_-_6477102 1.469 ENSMUST00000167717.2
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr17_+_6270475 1.461 ENSMUST00000088940.4
 Tmem181a
transmembrane protein 181A
chr13_+_23934434 1.426 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr9_-_18473559 1.318 ENSMUST00000034647.4
 Zfp558
zinc finger protein 558
chr11_+_75531690 1.305 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
 Slc43a2



solute carrier family 43, member 2



chr4_+_102421518 1.279 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr1_+_127306706 1.270 ENSMUST00000171405.1
 Mgat5
mannoside acetylglucosaminyltransferase 5
chr2_-_31116289 1.241 ENSMUST00000149196.1
 Fnbp1
formin binding protein 1
chr15_-_33687840 1.170 ENSMUST00000042021.3
 Tspyl5
testis-specific protein, Y-encoded-like 5
chr19_+_26753588 1.166 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr11_+_42419729 1.147 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr17_+_3532554 1.146 ENSMUST00000168560.1
 Cldn20
claudin 20
chr7_+_130936172 1.122 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr19_-_5510467 1.112 ENSMUST00000070172.4
 Snx32
sorting nexin 32
chr14_+_80000292 1.065 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr7_+_141029131 1.033 ENSMUST00000170892.1
 Gm17387
predicted gene, 17387

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.4 2.0 GO:0051012 microtubule sliding(GO:0051012)
0.0 1.8 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 1.8 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.3 1.6 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 1.6 GO:0035635 entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.2 1.5 GO:0009405 pathogenesis(GO:0009405)
0.1 1.5 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 1.5 GO:0032414 positive regulation of ion transmembrane transporter activity(GO:0032414)
0.0 1.4 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 1.4 GO:0006342 chromatin silencing(GO:0006342)
0.1 1.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.3 GO:0015807 L-amino acid transport(GO:0015807)
0.1 1.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 1.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 1.1 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.1 1.1 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.0 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.1 1.0 GO:0099515 actin filament-based transport(GO:0099515)
0.0 1.0 GO:0043113 receptor clustering(GO:0043113)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 2.1 GO:0016605 PML body(GO:0016605)
0.1 1.6 GO:0032584 growth cone membrane(GO:0032584)
0.0 1.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.3 GO:0005930 axoneme(GO:0005930)
0.1 1.2 GO:0071564 npBAF complex(GO:0071564)
0.1 1.2 GO:0097228 sperm principal piece(GO:0097228)
0.1 1.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 1.1 GO:0042581 specific granule(GO:0042581)
0.1 0.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.9 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.9 GO:0005771 multivesicular body(GO:0005771)
0.0 0.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 0.8 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 0.8 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.7 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.7 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.7 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.6 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.6 GO:1990635 proximal dendrite(GO:1990635)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 1.7 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.2 1.6 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 1.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.4 1.5 GO:0051378 serotonin binding(GO:0051378)
0.1 1.5 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.4 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.3 1.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 1.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 1.0 GO:0001221 transcription cofactor binding(GO:0001221)
0.2 0.9 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 0.8 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 0.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.8 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 0.8 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.2 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.6 REACTOME_ION_CHANNEL_TRANSPORT Genes involved in Ion channel transport
0.0 1.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.1 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.0 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 1.0 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.8 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.4 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.4 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.4 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.4 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates