Motif ID: Ets2

Z-value: 1.488


Transcription factors associated with Ets2:

Gene SymbolEntrez IDGene Name
Ets2 ENSMUSG00000022895.8 Ets2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ets2mm10_v2_chr16_+_95702044_957020940.823.5e-05Click!


Activity profile for motif Ets2.

activity profile for motif Ets2


Sorted Z-values histogram for motif Ets2

Sorted Z-values for motif Ets2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ets2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 7.541 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr6_+_5725812 5.995 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr15_-_66969616 4.354 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr17_+_3397189 4.296 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr4_+_128058962 4.193 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr9_-_29411736 4.060 ENSMUST00000115236.1
 Ntm
neurotrimin
chr1_-_56969864 4.058 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 4.012 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr13_-_59823072 3.659 ENSMUST00000071703.4
 Zcchc6
zinc finger, CCHC domain containing 6
chr10_-_53379816 3.541 ENSMUST00000095691.5
 Cep85l
centrosomal protein 85-like
chr3_-_80802789 3.331 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr7_-_4546567 3.258 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr5_-_44799643 3.184 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr15_-_43869993 3.102 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr5_+_117133567 2.801 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
 Taok3


TAO kinase 3


chr9_-_110476637 2.778 ENSMUST00000111934.1
ENSMUST00000068025.6
 Klhl18

kelch-like 18

chr2_-_5714490 2.740 ENSMUST00000044009.7
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr12_-_64965496 2.684 ENSMUST00000021331.7
 Klhl28
kelch-like 28
chr3_+_82358056 2.671 ENSMUST00000091014.4
 Map9
microtubule-associated protein 9
chr11_+_83302817 2.595 ENSMUST00000142680.1
 Ap2b1
adaptor-related protein complex 2, beta 1 subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.7 GO:0007266 Rho protein signal transduction(GO:0007266)
1.2 13.5 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.5 8.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.8 7.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.6 5.0 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.4 4.4 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.3 4.3 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.2 4.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 4.2 GO:0060612 adipose tissue development(GO:0060612)
0.0 3.4 GO:0016579 protein deubiquitination(GO:0016579)
1.1 3.3 GO:0019085 early viral transcription(GO:0019085)
0.1 3.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.3 3.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 3.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 2.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 2.8 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 2.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.5 2.7 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.4 2.7 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.9 2.6 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 13.5 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.2 10.5 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 9.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 9.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 7.1 GO:0031430 M band(GO:0031430)
0.0 5.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 5.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.5 4.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 4.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.5 4.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 4.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.7 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.3 3.5 GO:0071439 clathrin complex(GO:0071439)
0.2 3.5 GO:0032279 asymmetric synapse(GO:0032279)
0.8 3.3 GO:1990769 proximal neuron projection(GO:1990769)
0.3 2.9 GO:0032584 growth cone membrane(GO:0032584)
0.4 2.7 GO:0000235 astral microtubule(GO:0000235)
0.1 2.6 GO:0030673 axolemma(GO:0030673)
0.4 2.5 GO:0097443 sorting endosome(GO:0097443)
0.1 2.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 13.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 12.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 11.3 GO:0008565 protein transporter activity(GO:0008565)
0.1 10.3 GO:0030276 clathrin binding(GO:0030276)
0.1 7.1 GO:0030507 spectrin binding(GO:0030507)
0.0 6.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 4.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 4.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 4.0 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 4.0 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.7 3.6 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.6 3.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 3.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 3.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 3.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 3.0 GO:0051787 misfolded protein binding(GO:0051787)
0.1 3.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 2.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 4.7 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 4.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 4.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.0 PID_INSULIN_PATHWAY Insulin Pathway
0.1 3.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 2.7 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 2.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 1.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.6 PID_BCR_5PATHWAY BCR signaling pathway
0.0 1.6 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.3 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 1.1 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.0 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 1.0 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.3 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.4 8.7 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.4 6.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 5.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 4.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 4.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 3.2 REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4
0.0 2.8 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.1 2.6 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 2.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 2.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.4 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 2.4 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.1 1.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.9 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.8 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 1.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 1.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters