Motif ID: Nfe2_Bach1_Mafk

Z-value: 0.976

Transcription factors associated with Nfe2_Bach1_Mafk:

Gene SymbolEntrez IDGene Name
Bach1 ENSMUSG00000025612.5 Bach1
Mafk ENSMUSG00000018143.4 Mafk
Nfe2 ENSMUSG00000058794.6 Nfe2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafkmm10_v2_chr5_+_139791513_1397915390.608.5e-03Click!
Bach1mm10_v2_chr16_+_87698904_876989590.581.1e-02Click!
Nfe2mm10_v2_chr15_-_103251465_103251705-0.302.2e-01Click!


Activity profile for motif Nfe2_Bach1_Mafk.

activity profile for motif Nfe2_Bach1_Mafk


Sorted Z-values histogram for motif Nfe2_Bach1_Mafk

Sorted Z-values for motif Nfe2_Bach1_Mafk



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2_Bach1_Mafk

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 9.003 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr1_-_33907721 5.489 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr2_+_136713444 2.255 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr6_+_5725812 2.242 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr5_-_139484420 2.163 ENSMUST00000150992.1
 Zfand2a
zinc finger, AN1-type domain 2A
chr3_+_123267445 1.846 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr2_+_155775333 1.839 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr1_-_134235420 1.795 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr13_-_54611332 1.744 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr13_-_54611274 1.733 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr3_-_116968827 1.650 ENSMUST00000119557.1
 Palmd
palmdelphin
chr5_-_139484475 1.580 ENSMUST00000110851.1
ENSMUST00000079996.6
 Zfand2a

zinc finger, AN1-type domain 2A

chr2_+_156475803 1.387 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr2_+_25395866 1.364 ENSMUST00000028328.2
 Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr17_-_56133817 1.352 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr12_+_89812467 1.324 ENSMUST00000110133.2
ENSMUST00000110130.2
 Nrxn3

neurexin III

chr16_+_17561885 1.280 ENSMUST00000171002.1
ENSMUST00000023441.4
 P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr2_+_156475844 1.275 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr9_-_86695897 1.255 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr11_+_103171081 1.253 ENSMUST00000042286.5
 Fmnl1
formin-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 11.2 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 5.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.3 3.6 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 3.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 2.8 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.3 2.3 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.2 2.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.6 1.8 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.2 1.8 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.1 1.8 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 1.6 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 1.6 GO:0051438 regulation of ubiquitin-protein transferase activity(GO:0051438)
0.0 1.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.2 1.4 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.0 1.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.3 1.3 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.1 1.3 GO:0051014 actin filament severing(GO:0051014)
0.1 1.3 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 1.3 GO:0033198 response to ATP(GO:0033198)
0.0 1.3 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 11.2 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.3 3.6 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 2.9 GO:0071565 nBAF complex(GO:0071565)
0.0 2.7 GO:0001650 fibrillar center(GO:0001650)
0.6 2.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 2.0 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 1.9 GO:0043197 dendritic spine(GO:0043197)
0.1 1.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.8 GO:0032279 asymmetric synapse(GO:0032279)
0.1 1.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.7 GO:0005604 basement membrane(GO:0005604)
0.0 1.5 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.1 1.4 GO:0005605 basal lamina(GO:0005605)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.3 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.1 GO:0031932 TORC2 complex(GO:0031932)
0.3 1.0 GO:0031673 H zone(GO:0031673)
0.1 1.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 11.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 5.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 4.3 GO:0005096 GTPase activator activity(GO:0005096)
0.3 3.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 2.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 2.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 1.8 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.0 1.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.8 GO:0000149 SNARE binding(GO:0000149)
0.1 1.4 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.1 1.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 1.3 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.2 1.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 1.3 GO:0046965 retinoid X receptor binding(GO:0046965)
0.2 1.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 1.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.2 GO:0017124 SH3 domain binding(GO:0017124)
0.3 1.0 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.2 1.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 PID_ARF_3PATHWAY Arf1 pathway
0.0 3.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.4 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.2 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.1 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 1.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.0 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.0 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.9 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.8 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.6 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.5 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.8 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.2 4.5 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.2 2.6 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 2.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.8 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 1.7 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.3 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.2 1.0 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 0.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 0.9 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.9 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 0.8 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 0.7 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation