Motif ID: Hoxb1

Z-value: 0.747


Transcription factors associated with Hoxb1:

Gene SymbolEntrez IDGene Name
Hoxb1 ENSMUSG00000018973.2 Hoxb1



Activity profile for motif Hoxb1.

activity profile for motif Hoxb1


Sorted Z-values histogram for motif Hoxb1

Sorted Z-values for motif Hoxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 67 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_119053339 4.671 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr7_+_73391160 3.516 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr1_-_119053619 2.292 ENSMUST00000062483.8
 Gli2
GLI-Kruppel family member GLI2
chr3_+_127633134 2.240 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr5_-_24527276 1.647 ENSMUST00000088311.4
 Gbx1
gastrulation brain homeobox 1
chr1_+_127306706 1.465 ENSMUST00000171405.1
 Mgat5
mannoside acetylglucosaminyltransferase 5
chr8_-_87959560 1.424 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr1_+_153665274 1.407 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr2_+_84840612 1.201 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr1_-_45503282 1.134 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr14_-_69503220 1.116 ENSMUST00000180059.2
 Gm21464
predicted gene, 21464
chr19_-_41743665 1.115 ENSMUST00000025993.3
 Slit1
slit homolog 1 (Drosophila)
chr14_-_69284982 1.044 ENSMUST00000183882.1
ENSMUST00000037064.4
 Slc25a37

solute carrier family 25, member 37

chr8_+_84901928 1.020 ENSMUST00000067060.7
 Klf1
Kruppel-like factor 1 (erythroid)
chr5_+_139543889 1.014 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr14_-_69503316 1.003 ENSMUST00000179116.2
 Gm21464
predicted gene, 21464
chrX_+_110814390 0.948 ENSMUST00000078229.3
 Pou3f4
POU domain, class 3, transcription factor 4
chr9_+_65890237 0.926 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr7_+_119690026 0.903 ENSMUST00000047045.8
 Acsm4
acyl-CoA synthetase medium-chain family member 4
chr1_+_178798438 0.858 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 7.0 GO:0060032 notochord regression(GO:0060032)
0.3 3.5 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.0 2.2 GO:0021954 central nervous system neuron development(GO:0021954)
0.4 1.6 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 1.5 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 1.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 1.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 1.3 GO:0007628 adult walking behavior(GO:0007628)
0.0 1.2 GO:0015804 neutral amino acid transport(GO:0015804)
0.4 1.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 1.1 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.1 1.0 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 1.0 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 1.0 GO:0006826 iron ion transport(GO:0006826)
0.3 0.9 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.9 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0 0.9 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.3 0.8 GO:1990927 negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.1 0.8 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.0 GO:0097542 ciliary tip(GO:0097542)
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.4 1.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 1.0 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.1 0.8 GO:0032009 early phagosome(GO:0032009)
0.1 0.5 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.2 GO:0005858 axonemal dynein complex(GO:0005858)
0.0 0.1 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 3.5 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 2.2 GO:0070888 E-box binding(GO:0070888)
0.4 1.7 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.3 1.5 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 1.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 1.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.0 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 1.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.3 0.9 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 0.9 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.8 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 0.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.6 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs