Motif ID: Mecom

Z-value: 0.725


Transcription factors associated with Mecom:

Gene SymbolEntrez IDGene Name
Mecom ENSMUSG00000027684.10 Mecom



Activity profile for motif Mecom.

activity profile for motif Mecom


Sorted Z-values histogram for motif Mecom

Sorted Z-values for motif Mecom



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecom

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 7.174 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr7_-_103853199 1.669 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr5_+_66259890 0.989 ENSMUST00000065530.6
 Nsun7
NOL1/NOP2/Sun domain family, member 7
chr14_+_115042752 0.941 ENSMUST00000134140.2
 Mir17hg
Mir17 host gene 1 (non-protein coding)
chr1_+_152399824 0.783 ENSMUST00000044311.8
 Colgalt2
collagen beta(1-O)galactosyltransferase 2
chrX_+_112604274 0.715 ENSMUST00000071814.6
 Zfp711
zinc finger protein 711
chrX_-_37110257 0.679 ENSMUST00000076265.6
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr3_+_41742615 0.652 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chrX_-_88760312 0.644 ENSMUST00000182943.1
 Gm27000
predicted gene, 27000
chr9_-_13245741 0.552 ENSMUST00000110582.2
 Jrkl
jerky homolog-like (mouse)
chr1_+_156838915 0.521 ENSMUST00000111720.1
 Angptl1
angiopoietin-like 1
chr14_+_34375504 0.497 ENSMUST00000111908.1
 Mmrn2
multimerin 2
chr10_-_27616895 0.439 ENSMUST00000092639.5
 Lama2
laminin, alpha 2
chrX_-_113185485 0.438 ENSMUST00000026607.8
ENSMUST00000113388.2
 Chm

choroidermia

chr13_+_104287855 0.405 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr13_-_103764502 0.388 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr2_+_103970221 0.322 ENSMUST00000111140.2
ENSMUST00000111139.2
 Lmo2

LIM domain only 2

chr2_+_103970115 0.299 ENSMUST00000111143.1
ENSMUST00000138815.1
 Lmo2

LIM domain only 2

chrX_+_159627265 0.291 ENSMUST00000112456.2
 Sh3kbp1
SH3-domain kinase binding protein 1
chr6_+_113392417 0.284 ENSMUST00000032414.4
ENSMUST00000038889.5
 Ttll3

tubulin tyrosine ligase-like family, member 3

chr18_-_43477764 0.263 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr4_-_110292719 0.257 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr2_+_97467657 0.245 ENSMUST00000059049.7
 Lrrc4c
leucine rich repeat containing 4C
chr1_+_120006980 0.194 ENSMUST00000072886.4
 Sctr
secretin receptor
chr4_+_128846163 0.173 ENSMUST00000138291.1
 Gm12968
predicted gene 12968
chr11_-_81968415 0.169 ENSMUST00000066197.6
 Asic2
acid-sensing (proton-gated) ion channel 2
chr13_+_89540636 0.162 ENSMUST00000022108.7
 Hapln1
hyaluronan and proteoglycan link protein 1
chr11_-_50953745 0.160 ENSMUST00000162420.1
ENSMUST00000051159.2
 Prop1

paired like homeodomain factor 1

chr11_-_60046477 0.150 ENSMUST00000000310.7
ENSMUST00000102693.2
ENSMUST00000148512.1
 Pemt


phosphatidylethanolamine N-methyltransferase


chr15_-_48791933 0.148 ENSMUST00000160658.1
ENSMUST00000100670.3
ENSMUST00000162830.1
 Csmd3


CUB and Sushi multiple domains 3


chr13_+_109260481 0.145 ENSMUST00000153234.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr10_-_6980376 0.144 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr1_-_69685937 0.142 ENSMUST00000027146.2
 Ikzf2
IKAROS family zinc finger 2
chr2_-_45110336 0.139 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr2_+_103969528 0.133 ENSMUST00000123437.1
ENSMUST00000163256.1
 Lmo2

LIM domain only 2

chr2_-_149798701 0.124 ENSMUST00000148202.1
ENSMUST00000139471.1
 Gm14133

predicted gene 14133

chrX_+_159627534 0.121 ENSMUST00000073094.3
 Sh3kbp1
SH3-domain kinase binding protein 1
chr11_-_115367667 0.118 ENSMUST00000123428.1
ENSMUST00000044152.6
ENSMUST00000106542.2
 Hid1


HID1 domain containing


chr2_-_45110241 0.114 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr2_+_18672384 0.106 ENSMUST00000171845.1
ENSMUST00000061158.4
 Commd3

COMM domain containing 3

chr14_-_124677089 0.104 ENSMUST00000095529.3
 Fgf14
fibroblast growth factor 14
chr1_+_185454803 0.080 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr5_+_34525797 0.078 ENSMUST00000125817.1
ENSMUST00000067638.7
 Sh3bp2

SH3-domain binding protein 2

chr5_-_120467296 0.075 ENSMUST00000132916.1
 Sdsl
serine dehydratase-like
chrX_+_9885622 0.070 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr10_+_5593718 0.060 ENSMUST00000051809.8
 Myct1
myc target 1
chr9_+_59589288 0.050 ENSMUST00000121266.1
ENSMUST00000118164.1
 Celf6

CUGBP, Elav-like family member 6

chr1_-_189343342 0.040 ENSMUST00000079451.6
 Kcnk2
potassium channel, subfamily K, member 2
chr1_+_45311538 0.036 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr14_+_87416610 0.027 ENSMUST00000168275.1
ENSMUST00000169504.1
ENSMUST00000170865.1
 Tdrd3


tudor domain containing 3


chr9_+_72806874 0.026 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr18_+_80206887 0.014 ENSMUST00000127234.1
 Gm16286
predicted gene 16286
chr18_+_37504264 0.005 ENSMUST00000052179.6
 Pcdhb20
protocadherin beta 20
chr19_-_37176055 0.003 ENSMUST00000142973.1
ENSMUST00000154376.1
 Cpeb3

cytoplasmic polyadenylation element binding protein 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 7.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 1.7 GO:0015671 oxygen transport(GO:0015671)
0.1 1.0 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.3 GO:0018094 protein polyglycylation(GO:0018094)
0.1 0.4 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.1 0.8 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.2 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.2 GO:0060126 hypophysis morphogenesis(GO:0048850) somatotropin secreting cell differentiation(GO:0060126)
0.0 0.5 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.3 GO:1903056 melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.1 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.0 0.1 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 0.1 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.7 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.0 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.0 0.1 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.4 GO:0005605 basal lamina(GO:0005605)
0.0 0.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.4 1.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 0.3 GO:0070736 protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736)
0.0 0.8 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.4 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers