Motif ID: Stat5a

Z-value: 0.985


Transcription factors associated with Stat5a:

Gene SymbolEntrez IDGene Name
Stat5a ENSMUSG00000004043.8 Stat5a



Activity profile for motif Stat5a.

activity profile for motif Stat5a


Sorted Z-values histogram for motif Stat5a

Sorted Z-values for motif Stat5a



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat5a

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 2.643 ENSMUST00000075312.3
 Ttr
transthyretin
chr10_-_42583628 1.859 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr3_-_25212720 1.735 ENSMUST00000091289.3
 Gm10259
predicted pseudogene 10259
chr19_+_60144682 1.695 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr7_-_103853199 1.687 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr17_+_29090969 1.659 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr2_-_80447625 1.577 ENSMUST00000028389.3
 Frzb
frizzled-related protein
chr17_+_29093763 1.367 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr10_+_4710119 1.364 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr1_-_87156127 1.354 ENSMUST00000160810.1
 Ecel1
endothelin converting enzyme-like 1
chr16_-_22161450 1.329 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr16_-_23890805 1.322 ENSMUST00000004480.3
 Sst
somatostatin
chr1_+_90203980 1.247 ENSMUST00000065587.4
ENSMUST00000159654.1
 Ackr3

atypical chemokine receptor 3

chr9_-_79977782 1.242 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr11_-_26591729 1.225 ENSMUST00000109504.1
 Vrk2
vaccinia related kinase 2
chr2_-_168767136 1.196 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr14_-_48665098 1.155 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr15_-_93519499 1.140 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr18_+_58659443 1.066 ENSMUST00000025503.8
 Isoc1
isochorismatase domain containing 1
chr9_+_92250039 1.052 ENSMUST00000093801.3
 Plscr1
phospholipid scramblase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 402 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.9 GO:0071493 cellular response to UV-B(GO:0071493)
0.5 2.6 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 2.6 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
0.1 2.1 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.4 2.0 GO:0021764 amygdala development(GO:0021764)
0.1 1.8 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.3 1.7 GO:0015671 oxygen transport(GO:0015671)
0.5 1.6 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.4 1.5 GO:0019323 pentose catabolic process(GO:0019323)
0.4 1.5 GO:0046061 dATP catabolic process(GO:0046061)
0.1 1.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 1.5 GO:0051028 mRNA transport(GO:0051028)
0.5 1.4 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.3 1.4 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.3 1.3 GO:0070346 positive regulation of fat cell proliferation(GO:0070346)
0.1 1.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 1.3 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.4 1.2 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.3 1.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 1.2 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 189 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.0 3.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 2.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.8 GO:0015934 large ribosomal subunit(GO:0015934)
0.2 1.7 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.7 GO:0005581 collagen trimer(GO:0005581)
0.2 1.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 1.5 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 1.5 GO:0005925 focal adhesion(GO:0005925)
0.1 1.4 GO:0005688 U6 snRNP(GO:0005688)
0.0 1.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 1.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 1.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.2 1.2 GO:0042627 chylomicron(GO:0042627)
0.1 1.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 1.1 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 270 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 3.4 GO:0070324 thyroid hormone binding(GO:0070324)
1.0 3.0 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 2.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 2.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 2.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 2.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 1.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.4 1.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.5 1.5 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.5 1.4 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 1.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.4 1.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 1.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 1.1 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 1.1 GO:1990459 transferrin receptor binding(GO:1990459)
0.1 1.1 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 2.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 2.6 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 2.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.1 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 1.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 1.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 1.5 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 1.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.1 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.8 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 4.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 3.8 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.0 3.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.7 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 2.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 2.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 2.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 2.1 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.1 1.8 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.5 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.1 1.4 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.3 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 1.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.2 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.1 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules